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The Prognostic and Treatment Predictive Value of Proliferation and TIMP-1 in Breast Cancer

Popular Abstract in Swedish Varje år insjuknar mer än 8000 kvinnor i Sverige i bröstcancer, och 5 år efter diagnos är nära 90% fortfarande i livet. Trots att prognosen för majoriteten av patienterna är god, dör 1400 kvinnor årligen av bröstcancer. Till följd av detta pågår mycket forskningsarbete för att finna faktorer som bättre kan förutsäga prognos, prognostiska studier, men även för att finna Breast cancer is the most common tumour form and the second leading cause of death in solid tumours in women in the Western world. Despite improvements in the treatment, a considerable number of patients will relapse and die from their breast cancer. At the same time, a substantial number of patients will be over-treated, as they would have been cured by surgery and radiotherapy alone. In the meta

Contact allergy to fragrances with a focus on oak moss absolute

The exposure to fragrances is widespread and contact allergy to fragrance substances affects 1–4% of the general population. Many fragrance substances are volatile and it can therefore be suspected that they may evaporate from petrolatum patch test preparations applied in test chambers. In the first two papers included in this thesis the aims were to i) to investigate the stability of fragrance pr

Evaluation of Secondary Packages for Tetra Top on the Italian Market ? supportive tools for decision-making

Title Evaluation of secondary packages for Tetra Top on the Italian market? supportive tools for decision-making. Authors Viktor Eriksson and Monica Towman. Supervisors Annika Olsson, Department of Design Sciences, Division of Packaging Logistics, Lund Institute of Technology, Lund University. Armando Francione, Technical Director, Tetra Pak Italiana S.p.A. Problem Setting ? What requireme

Hyperlänken till det förflutna : tre nationalarkivs digitala lärmiljöer

The archival sector of today is geared towards the public more than ever before. Students are now expected to actively participate in a process of life-long learning, to be more conscious about their cultural heritage and to develop an awareness of history. They shall also be able to evaluate different kinds of sources and approach source material critically. The Anglo-Saxon archives are internati

Senkvartär stratigrafi och utveckling i Örseryd, mellersta Blekinge

Sammanfattning: Arbetets syfte var att göra en utvecklingshistorisk tolkning av området kring Örseryd, mellersta Blekinge. Ett 2000 x 600 m stort område ytkarterades, varefter olika enheter definierades och korrelerades med tidigare undersökningar utförda i Blekinge. Arbetet koncentrerades sedan till torvmarksområden påträffade under ytkarteringen. Tre torvmarksområden kan urskiljas inom undersöknSummary: The aim of this investigation was to study the Holocene history of a river valley near the village of Örseryd, situated in the middle part of the county of Blekinge in South Sweden. Covering 2000 x 600 m the area was investigated by survey mapping. Grain size analysis were made on representative samples and the different sediments were correlated to lithostratigraphic units defined in ear

aroma - An R object-oriented microarray analysis environment

We have implemented a self-contained package for DNA microarray analysis in R. The package is named aroma and is formerly known as com.braju.sma. The purpose of the package is to provide end-users with easy access to the latest statistical tools and methods, to provide other statisticians with a structured platform to develop and test new analysis methods, and to make our methods available to an a

Detection of inflammatory biomarkers associated with postural orthostatic tachycardia syndrome: insights from the SYSTEMA cohort

Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a cardiovascular dysautonomic condition affecting predominantly young women. POTS is defined as the presence of chronic symptoms of orthostatic intolerance associated with an increased heart rate ≥30 bpm, or heart rate exceeding 120 bpm, within 10 minutes of standing or head-up tilt in the absence of orthostatic hypotension. The etio

Ämnade för restaurangarbete? : Om politisk styrning och lågutbildade ungdomars väg fram till arbetsmarknadens tröskel

Den första januari 2012 sänkte den då sittande alliansregeringen momssatsen för restaurang- och cateringtjänster från 25 % till 12 %. Det övergripande målet med den lägre momssatsen är att stimulera efterfrågan på okvalificerad arbetskraft genom att skapa förutsättningar för lägre priser och därmed ökad efterfrågan på restaurangföretagens tjänster.Under tiden efter genomförandet av den sänkta momsA significant part of the labour market debate is devoted to issues concerning problematic youth. Expressions like “the lost generation” is coined to address the very core of the matter. It captures the difficulties for low-skilled young people to gain a sustainable work life in an education-oriented society. A strategy to increase employment opportunities specifically suited for the latter group

Molecular phylogeny and higher systematics of the metalmark butterflies (Lepidoptera: Riodinidae)

Riodinidae is a highly diverse buttery family with the majority of its genera restricted to the Neotropics and, despite previous efforts, its higher systematics remains unresolved. Here, we propose a novel phylogenetic hypothesis, based on a comprehensive sample of riodinids, primarily from the Neotropics, covering 67% of all genera and all of the major lineages. We sequenced nine molecular marke

Role of Wnt-5a in breast cancer

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos västerländska kvinnor. I Sverige kommer var tionde kvinna att drabbas av bröstcancer, vilket motsvarar drygt 5000 kvinnor om året. Dödligheten i bröstcancer är 30%. Detta innebär att en tredjedel av de som drabbas kommer att dö av sin sjukdom. Det är dock inte själva tumören i bröstet som dödar eftersom denna i princip alltBreast cancer is one of the most common cancer forms in the industrialized world. Only in Sweden, nearly 6000 women are diagnosed with breast cancer each year and 1/3 of them eventually succumb to the disease. Wnts are a family of genes that have been implicated in many human tumours, so far mainly studied in colorectal cancer where activated Wnt signalling occurs in a vast majority of tumours. Wh

Regulation of the exocrine pancreas in growing pigs, with special emphasis on entero-pancreatic reflexes

Popular Abstract in Swedish Bukspottkörteln (pankreas) består av en exocrin och en endocrin del. Den exocrina delen som studerats i denna avhandling innerhåller acinarceller som producerar bukspott innehållande matsmältningsenzymer. Dessa enzymer spjälkar proteiner, kolhydrater och fetter som finns i födan, till sina mindre beståndsdelar aminosyror, monosackarider och fettsyror. Efter sekretion av

Surface Wave Testing of Pavements

A novel approach for surface wave testing of pavements is presented. It is a non-destructive testing (NDT) technique that can be used to obtain the thickness and stiffness properties of the different layers in a pavement. With this method structural properties of the pavement can be mapped as a function of time and space, providing a valuable tool in pavement design and management. The technical d

Recognition and Separation of Hemoglobin Variants via Molecularly Imprinted Polymers

Hemoglobin (Hb) is the predominant protein in red blood cells with allosteric regulation mechanisms for delivering oxygen between the lungs and tissues. After the 1980s, concentrated research on modified Hb emerged because of the necessity for the development of a blood substitute (oxygen carrier). Several purification procedures and genetic/chemical modifications of Hb have been undertaken by bot

Exploring the Propanediol Utilization Pathway in Lactobacillus reuteri

Concerns regarding environmental issues have led to increasing efforts for investigating sustainable production routes for the future industry that is based on renewable resources. Among the biobased chemicals, the C3-chemicals 3-hydroxypropionaldehyde (3-HPA), 1,3-propanediol (1,3-PDO) and 3-hydroxypropionic acid (3-HP), have been identified as top candidates for the chemical industry. Lactobacil

Capacity-building for interdisciplinary research on aging and health – experiences of graduate level initiatives in a national and international context

Abstract Body:Starting out from a joint Nordic collaboration initiative in 2008 resulting in the development of a Nordic Master Program in Gerontology (NordMaG), followed by the establishment of graduate schools integrated with two national excellence centers for aging research in Sweden, in 2014 the Swedish National Graduate School for Competitive Science on Aging and Health (SWEAH) was establish

Hygrothermal Simulations of Buildings Concerning Uncertainties of the Future Climate

Global warming and its effects on climate are of great concern. Climate change can affect buildings in different ways, i.e. it can change the energy demand or the moisture durability of buildings in the future. In Sweden, most of the last 20 years have been mild and wet compared to the 1961-1990 climate reference period. Future needs and risks of the building sector depend on the future climate wh

Term amniotic fluid : An unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications

Background: Mesenchymal stromal cells (MSCs) are currently being evaluated in numerous pre-clinical and clinical cell-based therapy studies. Furthermore, there is an increasing interest in exploring alternative uses of these cells in disease modelling, pharmaceutical screening, and regenerative medicine by applying reprogramming technologies. However, the limited availability of MSCs from various