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Genetic Variants of GSK3B are Associated with Biomarkers for Alzheimer's Disease and Cognitive Function.

Background: Glycogen synthase kinase 3 beta (GSK3B) is the major kinase phosphorylating tau protein. Hyperphosphorylated tau is one of the hallmarks of Alzheimer's disease (AD). Despite extensive research, the role of GSK3B in AD pathogenesis is not fully understood. Objective: To evaluate possible associations between gene variants of GSK3B and risk of AD. Methods: Twelve GSK3B tag single-nucleot

Electric Versus Manual Tooth Brushing among Neuroscience ICU Patients: Is it Safe?

Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia.

Quantitative numerical analysis of flow past a circular cylinder at Reynolds number between 50 and 200

Results of numerical simulations are presented for flow past a stationary circular cylinder at low Reynolds numbers (Re=50-200). The simulations were carried out using a finite-volume code employing a fractional step method with second-order accuracy in both space and time. A sensitivity study on numerical parameters concerning the domain size, grid independence and time step resolution was carrie

Hematopoietic stem and progenitor cells and potentials for application in fetal cell replacement therapy

Fetal cell replacement therapy or in utero hematopoietic cell transplantation (IUHCT) is proposed as a non-myeloablative alternative to bone marrow transplantation (BMT) for a number of inborn immunologic, hematologic and metabolic disorders. IUHCT represents the method through which variable amounts of natural or genetically modified hematopoietic cells can be transferred to the fetal recipient i

LIF study of mixing in a model of a vein punctured by a cannula

Clinical manifestations of atherosclerosis in an elderly population are related to plasma neopterin, NGAL and endothelin-1, but not to Chlamydia pneumoniae serology.

Highly mobile insectivorous swifts perform multiple intra-tropical migrations to exploit an asynchronous African phenology

Cell-based evidence regarding the role of FSH in prostate cancer

Association between added sugar intake and mortality is nonlinear and dependent on sugar source in 2 Swedish population-based prospective cohorts

Greater carbon allocation to mycorrhizal fungi reduces tree nitrogen uptake in a boreal forest

Role of forest regrowth in global carbon sink dynamics

How planetary growth outperforms migration

Planetary migration is a major challenge for planet-formation theories. The speed of type-I migration is proportional to the mass of a protoplanet, while the final decade of growth of a pebble-accreting planetary core takes place at a rate that scales with the mass to the two-thirds power. This results in planetary growth tracks (i.e., the evolution of the mass of a protoplanet versus its distanc

Effects of Geriatric Team Rehabilitation After Hip Fracture : Meta-Analysis of Randomized Controlled Trials

Benzylpenicillin versus wide-spectrum beta-lactam antibiotics as empirical treatment of Haemophilus influenzae-associated lower respiratory tract infections in adults; a retrospective propensity score-matched study

Prediction of midlife hand osteoarthritis in young men

Objectives: Improved prediction modeling in osteoarthritis (OA) may encourage risk reduction through calculation of individual and population lifetime risks. There are currently no prediction models for hand OA. Thus, we aimed to 1) develop a prediction model for hand OA in men and 2) to contrast its discriminative performance to a prediction model for lung cancer and chronic obstructive pulmonary

Effect of Piston Geometry on Stratification Formation in the Transition from HCCI to PPC

Impact of PCSK9 loss-of-function genotype on 1-year mortality and recurrent infection in sepsis survivors

Prenatal lead exposure is associated with decreased cord blood DNA methylation of the glycoprotein VI gene involved in platelet activation and thrombus formation

Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE) : A prospective birth cohort in northern Sweden

Introduction Prenatal and neonatal environmental factors, such as nutrition, microbes and toxicants, may affect health throughout life. Many diseases, such as allergy and impaired child development, may be programmed already in utero or during early infancy. Birth cohorts are important tools to study associations between early life exposure and disease risk. Here, we describe the study protocol of