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Huntington's disease is a neurodegenerative disorder caused by an abnormal CAG repeat expansion within exon 1 of the huntingtin gene HTT. While several genetic modifiers, distinct from the Huntington's disease locus itself, have been identified as being linked to the clinical expression and progression of Huntington's disease, the exact molecular mechanisms driving its pathogenic cascade and clini

I övergången mellan de triassiska och jurassiska perioderna, för ca 200 miljoner år sedan, inträffade ett massutdöende som bedöms ha koppling till vulkanism i den Centralatlantiska magmatiska provinsen (CAMP). En signifikant ökning av växthusgaser som koldioxid (CO2) eller metan (CH4) och andra flyktiga ämnen, med efterföljande global uppvärmning som följd, föreslås vara den viktigaste drivkrafter

Populärvetenskaplig sammanfattning: Hjälper Nhandugue-flodens vatten Urema-sjön i Gorongosa Nationalpark, Moçambique, från att torka ut? I de centrala delarna av Moçambique ligger Gorongosa Nationalpark som skyddar ett omfattande ekosystem av flodplan, gräsmarker och skogsbeklädda områden. Efter drygt 20 år av inbördeskrig hade 1994 antalet stora däggdjur, så som lejon, zebror och bufflar, minskatGorongosa National Park in central Mozambique is situated at the southernmost extension of the East African Rift System (EARS), the Urema Rift. The park is protecting a vast ecosystem of floodplains, grasslands and woody coverage. From 20 years of civil war the large-mammal population in the park had in year 1994 been reduced by 90 % or more, and in 2004 a restoration project was started in order

Under de senaste åren har det skett ett skifte i den Europeiska Unionens migrationspolitik mot ett ökat användande av informella återtagandeavtal. En vanlig kritik mot informella återtagandeavtal är att den informella formen är ett hinder mot parlamentarisk och juridisk granskning. Det kan ha alvarliga konsekvenser på grund av den påverkan informella återtagandeavtal kan ha på migranters rätt att

I denna studie undersöks bildningsprocesser och klimatologisk betydelse av hur av årsmoräner bildas vid Gornergletscher, en stor alpin dalglaciär i de södra schweiziska Alperna. Ett särskilt fokus ligger på moränryggar som har bildats mellan 2007 och 2019, en period då glaciären har retirerat snabbt och det har skett en tydlig förtunning av isfronten. Dessa moräner uppvisar olika geomorfologiska o

The protein kinase C (PKC) family of serine/threonine kinases consists of 10-15 members. The PKC isoforms have central roles in many essential cellular processes, including proliferation, apoptosis, differentiation, cytoskeletal changes, and migration. The PKC family can be subgrouped into classical, novel and atypical isoforms depending on structure and sensitivity to the activators diacylglycero

To better utilize existing wireless systems, they can be combined together to interact and thereby provide better balanced capacity. They can further profit from this by getting their ongoing connection moved from the current system to another. The main issues are to make this move without losing the ongoing connection and to make it seamless, i.e., without the user noticing it. This action of mov

Popular Abstract in Swedish För att ett transplanterat organ ska accepteras av mottagaren behövs immunhämmande läkemedel. Dessa läkemedel dämpar immunförsvaret och förhindrar avstötning av det transplanterade organet. Immunförsvaret har olika sätt att angripa organet, som det uppfattar som kropps-främmande. Idag används olika läkemedel i kombination som behandling mot avstötning. Tyvärr är dessa mTransplantation of vital organs is today a widely used treatment when failure of the organ is a fact. To prevent rejection immunosuppresive treatment must be maintained lifelong, unless transplantation is perfomed between identical twins. Many immunosuppresive agents introduced in clinical practice have been benificial in improving graft survival rates, but adverse effects remains a huge problem t

Huntington's disease (HD), a fatal neurodegenerative disorder, is associated with an increased risk of diabetes mellitus. The reason for this is unknown, but considering the functional similarities of neurons and the insulin secreting pancreatic β-cell, pathological mechanisms may be shared by both cell types and account for neuronal as well as endocrine dysfunction. Hence, finding the mechanisms

Objectives Evidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma

Popular Abstract in Swedish Blodet är sammansatt av många olika typer av mogna celler som är ansvariga för specialiserade roller inom blodsystemet. Röda blodceller transporterar syre till kroppens celler, vita blodceller förser oss med försvar mot mikroorganismer och blodplättar ser till att stoppa blödningar. Nybildning av blodceller behövs kontinuerligt eftersom vissa celler lever bara i några dThe blood is composed of many different cell types that through tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. This is an extremely important feature of HSCs in order to ensure the existence of the HSC pool that is paramount to provide life-long hematopoiesis. Aging is in ge

This thesis is to look into media representation on issues that involve female marriage migrants, in particular, in relation to citizenship, in Singapore, one of the most popular destinations of marriage migration in Asia. Categorized and labeled as “foreign brides” in Singapore, these foreign-born women have long suffered from biased or one-dimensional representation in the local media, particula

This thesis examines and analyses the relationship between the principle of complementarity and the principle of universal jurisdiction. The establishment of the International Criminal Court provides for the first time in history a permanent international criminal institution. One of the most important principles on which the ICC is built upon is the principle of complementarity. The road towards