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A common model for the breathlessness experience across cardiorespiratory disease
Chronic breathlessness occurs across many different conditions, often independently of disease severity. Yet, despite being strongly linked to adverse outcomes, the consideration of chronic breathlessness as a stand-alone therapeutic target remains limited. Here we use data-driven techniques to identify and confirm the stability of underlying features (factors) driving breathlessness across differ
Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome : A Clinical Association
Does microbiological contamination of homografts prior to decontamination affect the outcome after right ventricular outflow tract reconstruction?
From electronic structure to combustion model application for acrolein chemistry part I : Acrolein + H reactions and related chemistry
The bacterial amyloids phenol soluble modulins from staphylococcus aureus catalyze alpha-synuclein aggregation
Aggregated α-synuclein (α-syn) is the main constituent of Lewy bodies, which are a pathological hallmark of Parkinson’s disease (PD). Environmental factors are thought to be potential triggers capable of initiating the aggregation of the otherwise monomeric α-syn. Braak’s seminal work redirected attention to the intestine and recent reports of dysbiosis have highlighted the potential causative rol
Similar migration for medial congruent and cruciate-retaining tibial components in an anatomic TKA system : a randomized controlled trial of 60 patients followed with RSA for 2 years
Do therapeutic imagery practices affect physiological and emotional indicators of threat in high self-critics?
The effect of postoperative anticoagulation on false lumen patency after surgery for acute type A aortic dissection
Diabetes Mellitus as a Risk Factor for Trigger Finger – a Longitudinal Cohort Study Over More Than 20 Years
Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability
First measurements of N-subjettiness in central Pb-Pb collisions at √sNN = 2.76 TeV
The ALICE Collaboration reports the first fully-corrected measurements of the N-subjettiness observable for track-based jets in heavy-ion collisions. This study is performed using data recorded in pp and Pb-Pb collisions at centre-of-mass energies of s = 7 TeV and sNN = 2.76 TeV, respectively. In particular the ratio of 2-subjettiness to 1-subjettiness, τ2/τ1, which is sensitive to the rate of two
Methods and results used in the development of a consensus-driven extension to the Consolidated Standards of Reporting Trials (CONSORT) statement for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE)
Ablation of Aquaporin-9 Ameliorates the Systemic Inflammatory Response of LPS-Induced Endotoxic Shock in Mouse
Proteome profiling of recombinant DNase therapy in reducing NETs and aiding recovery in COVID-19 patients
Severe COVID-19 can result in pneumonia and acute respiratory failure. Accumulation of mucus in the airways is a hall mark of the disease and can result in hypoxemia. Here, we show that quantitative proteome analysis of the sputum from severe COVID-19 patients reveal high levels of neutrophil extracellular trap(s) (NETs) components, which was confirmed by microscopy. Extracellular DNA from excessi
Serum zinc and dietary intake of zinc in relation to risk of different breast cancer subgroups and serum levels as a marker of intake: a prospective nested case-control study
Combining in-cylinder pressure and 1D simulation tools to understand the combustion characteristics of natural gas in pre-chamber ignition systems for energy generation
Recent outlooks suggest a long-term relevance of internal combustion engines for both power generation and transportation. Nonetheless, stringent pollutant reduction requirements combined with new CO2 mandates draws a challenging scenario, requiring intensive research and development activities to develop and optimize combustion modes to fulfill these requirements. Among the recent advancements, t
Autoantibodies in Rheumatoid Arthritis – Laboratory and Clinical Perspectives
Measurement of two groups of autoantibodies, rheumatoid factor (RF) and anti-citrullinated protein/peptide antibodies (ACPA) have gained increasing significance in the diagnosis and classification of rheumatoid arthritis (RA) over the last 65 years. Despite this rising importance of autoimmune serology in RA, there is a palpable lack of harmonization between different commercial RF and ACPA tests.