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Alpha10 integrin expression is up-regulated on fibroblast growth factor-2-treated mesenchymal stem cells with improved chondrogenic differentiation potential.

Mesenchymal stem cells (MSCs) are multipotent cells that have the capacity to differentiate into various different cell lineages and can generate bone, cartilage and adipose tissue. MSCs are presently characterized using a broad range of different cell-surface markers that are not exclusive to MSCs and not sensitive to culture conditions or differentiation capacity. We show that the integrin subun

Transgressive oolites onlapping a Silurian rocky shoreline unconformity, Gotland, Sweden.

Stratigraphical relationships, facies and petrographical evidences define a rocky shoreline in the Late Wenlock of Gotland. The major facies-elements forming the rocky shoreline are 1) several subaerially exposed reefs, which were eroded during falling base-level and which form the topography, and 2), onlap of oolite grainstones which were deposited during the subsequent rise of the base-level. Fi

Association between a variant in the 11 beta-hydroxysteroid dehydrogenase type 2 gene and primary hypertension

The enzyme 11 beta-hydroxysteroid dehydrogenase type 2 (11BHSD2) converts cortisol to cortisone in the kidney, thereby protecting the mineralocorticoid receptor from the mineralocorticoid actions of cortisol. The syndrome of Apparent Mineralocorticoid Excess (AME), a rare monogenic form of early onset hypertension with autosomal recessive inheritance, is caused by homozygous or compound heterozygo

The effect of bone quality on the stability of ankle arthrodesis. A finite element study

Background: Despite uniform operating techniques, lack of fusion still occurs after ankle arthrodesis. Differences in the biological healing potential may be a factor but the mechanical performance of the arthrodesis construct because of varying bone quality also may be important. Internal compression techniques are preferred because of higher union rates, shorter fusion times, and fewer complicat

High-order surface tension VOF-model for 3D bubble flows with high density ratio

An improved Volume of Fluid (VOF) method is presented which is applicable to high density ratio 3D flows for a large range of bubble Reynolds number (Re). The method is based on the Navier-Stokes equations for incompressible multi-phase flows which are discretized on a Cartesian staggered grid. The multi-grid technique together with the pressure-velocity coupling scheme for multi-phase flows have