Search results

https://www.cec.lu.se/staff-pages/staff-newsletters/march-19th-2020 - 2026-05-19

Epigenetic modifications triggered by high glucose may predispose to diabetes risk by regulating gene expression activity. A growing body of evidence suggests that histone modification which is an essential component of epigenetic mechanism may play an important role in the development of type 2 diabetes (T2D) and its complications. In this thesis, the overarching aim is to map histone modificatio

Popular Abstract in Swedish När vi äter ökar nivån av blodsocker (blodglukos) i blodet. Glukos forslas i blodet till målvävnader, såsom fett och skelettmuskel, där det används som energi. Men för att glukos ska kunna tas upp av målvävnaden krävs insulin. Insulin är ett hormon som produceras av beta-celler i bukspottkörtelns Langerhanska öar, vars sekretion ut i blodet regleras av blodglukos. Då deType 2 diabetes (T2D) is a condition of high blood glucose levels due to insulin resistance and defective insulin secretion. Impaired insulin secretion plays a major role in the pathophysiology of T2D, it is mainly attributed to beta cell function i.e. failure to secrete insulin or reduced beta cell mass. The exocytotic process is crucial for beta cell function and its dysregulation leads to impai

Popular Abstract in Swedish Långlivade klororganiska miljögifter (POP) som polyklorerade bifenyler (PCB), dioxiner och och insektsgiftet diklordifenyltrikloretan (DDT) har sedan decennier funnits i vår miljö. PCB framställdes genom klorering av bifenyl och det finns 209 olika varianter. En av dessa är CB-153, vilken är den vanligast förkommande PCB varianten, och vi har använt denna som biomarkör Persistent organochlorine pollutants (POPs), such as polychlorinated biphenyls (PCB) and the insecticide dichloro-diphenyl-dichloro-ethylene (DDT) have been released into the environment mainly since the second World War. POPs accumulate especially in highly ranked predators of the aquatic food chain. In Sweden, the major exposure route for POPs are through consumtion of fatty fish, such as salmon

In a world where distributed power generation and deregulation of energy markets are on everyone's agenda, the need for highly efficient power plants with short lead times is greater than ever. Although at present combined cycles provide a solution, development of ever more advanced machines to increase efficiency and lower the environmental impact has led to high maintenance costs and a decrease

Most types of materials and components use heating during the manufacturing process, with a large potential for cost and energy savings. Induction heating is the most energy efficient industrial heating technology for many applications, but so far technical limitations has delayed large scale introduction. The difficulties relate to heating of large flat and curved surfaces, and, perhaps most impo

Populärvetenskaplig sammanfattning: Våtmarkers utvecklingshistoria kan rekonstrueras genom att deras lagerföljd undersöks. Genom att studera de sediment, växtdelar och pollen som en våtmark är uppbyggd av kan man dra slutsatser om hur den bildats och hur dess utbredning varierat på grund av klimatförändringar och/eller mänsklig påverkan. Rekonstruktioner av förändringar i våtmarkers utbredning bidWetlands are of uttermost biological importance as they function as natural purifiers, absorb nitrogen, and contribute to the landscape biodiversity. In a long term, the history and change, in area- and volume extent, of wetlands reflect climate trends through time. This master’s thesis is an attempt to develop a methodology that in a simple and robust way reconstructs wetland changes using sedime

Organiserad brottslighet har under de senaste åren varit en viktig kriminalpolitisk fråga och är det än idag. Media rapporterar frekvent om skjutningar kopplade till hämndaktioner i den kriminella miljön, problem i de utsatta områdena, mord som inte går att klara upp samt företag som förskingrat miljonbelopp. Det ska nämnas att den organiserade brottsligheten har bytt skepnad genom tiderna. Mångsi

Background: Core outcome sets (COSs) are important and necessary as they help standardize reporting in research studies. Cranioplasty following traumatic brain injury (TBI) or stroke is becoming increasingly common, leading to an ever-growing clinical and research interest, especially regarding the optimal material, cost-effectiveness, and timing of cranioplasty concerning neurological recovery an

Stommen för den europeiska konkurrensrätten har till stor del utvecklats från Freiburgskolans ordoliberala ideal, enligt vilken konkurrensprocessen och individens handlingsfrihet sågs som förutsättningar för ett fritt samhälles existens. Med syfte att upprätta en gemensam inre marknad gjordes formalistiska avtalstolkningar under artikel 101 FEUF där vertikala avtals välfärdseffekter inte gärna erkThe concept of a united European community might not be Ordoliberal but the foundation of what it is built upon is to a large extent. The project of integrating the European markets was seen as an important peace keeping incentive and according to Ordoliberal ideals the competition process was regarded as a crucial component of a social market economy. Both the European Court and the European Comm

Upphandling av offentliga kontrakt är av stor ekonomisk betydelse och beräknas i Sverige uppgå till drygt 600 miljarder kronor. Den offentliga upphandlingen används dessutom i allt större utsträckning för att uppnå samhällsekonomiska och arbetsmarknadspolitiska mål. Nya EU direktiv på upphandlingsområdet ska underlätta för upphandlande myndigheter att i större omfattning beakta arbetsrättsliga häPurchases bound by public procurement rules is estimated to exceed 600 billion SEK. Public procurement is also increasingly used as a means for achieving socio-economical and labour market policy targets. New procurement directives adopted by the EU in 2014 are intended to facilitate a higher regard for labour law by the contracting authorities. These new directives have yet to be implemented in

Digitaliseringen har inte bara revolutionerat vår vardag och hur vi kommunicerar utan även skapat en ny arena för brottslighet. Bland de mest bekymmersamma brotten som har ökat i takt med den digitala utvecklingen är sexuella övergrepp mot barn. I syfte bekämpa och förebygga dessa brott presenterade EU-kommissionen 2022 ett förslag till en förordning som ålägger leverantörer av interpersonella komDigitalization has not only revolutionized our daily lives and how we communicate but has also created a new arena for criminal activity. Among the most concerning crimes that have increased with the rise of digital development is child sexual abuse. In order to combat and prevent these crimes, the European Commission presented a proposal for a regulation in 2022 that obliges providers of interper

The increasing amount of renewable energy in the electrical grid comes with several challenges, of which overvoltage and congestion (overcurrents) are the subjects of this work. One flexible way of handling these problems is active management by some control system. There is a trade-off between simplicity when implementing the control system and the performance. In the project Active Network Manag

As people travel more than ever before, transport and infrastructure is growing in all Swedish cities. With growing emission levels of nitrogen dioxide, greenhouse gases and particles, and an increasing risk of traffic-related accidents, parking strategy is a key component in planning and securing the healthy development of the city's infrastructure. For new construction and rebuilding a parki