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SimCA∗ : A control-theoretic approach to handle uncertainty in self-adaptive systems with guarantees

Self-adaptation provides a principled way to deal with software systems' uncertainty during operation. Examples of such uncertainties are disturbances in the environment, variations in sensor readings, and changes in user requirements. As more systems with strict goals require self-adaptation, the need for formal guarantees in self-adaptive systems is becoming a high-priority concern. Designing se

Mapping of the discontinuous kininogen binding site of prekallikrein : A distal binding segment is located in the heavy chain domain A4

Prekallikrein, the precursor to the serine proteinase kailikrein, circulates in plasma in an equimolar complex with H-kininogen. The binding to H-kininogen is mediated by the kallikrein heavy chain consisting of four "apple" domains, A1-A4, which attaches to H-kininogen with high specificity and affinity (KD = 83 UM). At least two distinct portions of the kallikrein heavy chain form this H-kininog

Reconciling the Greenland ice-core and radiocarbon timescales through the Laschamp geomagnetic excursion

Cosmogenic radionuclides, such as 10Be and 14C, share a common production signal, with their formation in the Earth's upper atmosphere modulated by changes to the geomagnetic field, as well as variations in the intensity of the solar wind. Here, we use this common production signal to compare between the radiocarbon (IntCal)and Greenland ice-core (GICC05)timescales, utilising the most pronounced c