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The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin

Tumors are phenotypically heterogeneous and include subpopulations of cancer cells with stemlike properties. The natural product salinomycin, a K+-selective ionophore, was recently found to exert selectivity against such cancer stem cells. This selective effect is thought to be due to inhibition of the Wnt signaling pathway, but the mechanistic basis remains unclear. Here, we develop a functionall

Teacher Beliefs and Practices : Multilingualism in English Classrooms

Recent statistics on language diversity among pupils in Swedish secondary school classrooms show that 24% have another L1 than Swedish. Thus, classrooms are multilingual spaces. In the English subject, an 'English Only' ideology dominates, where classrooms are exclusively English-medium, an ideology endorsed by educational policy, agencies like the Swedish Schools Inspectorate, and teacher educato

Postural orthostatic tachycardia syndrome : clinical presentation, aetiology and management

Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular autonomic disorder characterized by an excessive heart rate increase on standing and orthostatic intolerance. POTS affects younger individuals 15–45 years old with a distinct female predominance (≈80%). The prevalence ranges between 0.2% and 1.0% in developed countries. The onset of POTS is typically precipitated by im

Using the thermal mass of a building to reduce the magnitude of the peak power demand of the primary heating system : A whole building simulation with parametric analysis

The idea of using the thermal mass of a building to maintain a more constant indoor climate is not new. This particular propertyof a building, including its exterior envelope, plays an important part in the reduction of peak power demands, which is becomingan increasingly urgent issue for the heating energy suppliers. The latest smart-grid technology creates new opportunities wherecommunication be

Disappearance of myocardial perfusion defects on prone SPECT imaging : Comparison with cardiac magnetic resonance imaging in patients without established coronary artery disease

Background: It is of great clinical importance to exclude myocardial infarction in patients with suspected coronary artery disease who do not have stress-induced ischemia. The diagnostic use of myocardial perfusion single-photon emission computed tomography (SPECT) in this situation is sometimes complicated by attenuation artifacts that mimic myocardial infarction. Imaging in the prone position ha

Amine-β-cyclodextrin-based nanosponges. The role of cyclodextrin amphiphilicity in the imidacloprid uptake

This paper describes the synthesis, characterization and sorption performance of cyclodextrin nanosponges (NSs). Cyclodextrins are cyclic oligosaccharides with remarkable amphiphilic properties, allowing for a vast range of applications. The synthesis of nanosponges of β-cyclodextrins was carried out using two uncommon cross-linkers: hexane-1,6-diamine (am6) and dodecane-1,12-diamine (am12). It ha