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The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
Tumors are phenotypically heterogeneous and include subpopulations of cancer cells with stemlike properties. The natural product salinomycin, a K+-selective ionophore, was recently found to exert selectivity against such cancer stem cells. This selective effect is thought to be due to inhibition of the Wnt signaling pathway, but the mechanistic basis remains unclear. Here, we develop a functionall
The predictive role of ultrasound-detected tenosynovitis and joint synovitis for flare in patients with rheumatoid arthritis in stable remission. Results of an Italian multicentre study of the Italian Society for Rheumatology Group for Ultrasound : The STARTER study
Expression of programmed cell death protein 1 (PD-1) and its ligand PD-L1 in colorectal cancer : Relationship with sidedness and prognosis
Teacher Beliefs and Practices : Multilingualism in English Classrooms
Recent statistics on language diversity among pupils in Swedish secondary school classrooms show that 24% have another L1 than Swedish. Thus, classrooms are multilingual spaces. In the English subject, an 'English Only' ideology dominates, where classrooms are exclusively English-medium, an ideology endorsed by educational policy, agencies like the Swedish Schools Inspectorate, and teacher educato
The prediction of moisture and temperature distribution in a concrete reactor containment
Increasing cognitive interference modulates the amplitude of the auditory brainstem response
Postural orthostatic tachycardia syndrome : clinical presentation, aetiology and management
Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular autonomic disorder characterized by an excessive heart rate increase on standing and orthostatic intolerance. POTS affects younger individuals 15–45 years old with a distinct female predominance (≈80%). The prevalence ranges between 0.2% and 1.0% in developed countries. The onset of POTS is typically precipitated by im
Maternal selenium status and neuropsychological development in Spanish preschool children
Prenatal arsenic exposure is associated with increased plasma IGFBP3 concentrations in 9-year-old children partly via changes in DNA methylation
Selenium status during pregnancy : Influential factors and effects on neuropsychological development among Spanish infants
Acute uncomplicated diverticulitis managed without antibiotics–difficult to introduce a new treatment protocol but few complications
Familial and second primary pancreatic cancers : a nationwide epidemiologic study from Sweden
Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets
Reduced workforce participation 5 years prior to first Parkinson’s disease sick-leave
Using the thermal mass of a building to reduce the magnitude of the peak power demand of the primary heating system : A whole building simulation with parametric analysis
The idea of using the thermal mass of a building to maintain a more constant indoor climate is not new. This particular propertyof a building, including its exterior envelope, plays an important part in the reduction of peak power demands, which is becomingan increasingly urgent issue for the heating energy suppliers. The latest smart-grid technology creates new opportunities wherecommunication be
Disappearance of myocardial perfusion defects on prone SPECT imaging : Comparison with cardiac magnetic resonance imaging in patients without established coronary artery disease
Background: It is of great clinical importance to exclude myocardial infarction in patients with suspected coronary artery disease who do not have stress-induced ischemia. The diagnostic use of myocardial perfusion single-photon emission computed tomography (SPECT) in this situation is sometimes complicated by attenuation artifacts that mimic myocardial infarction. Imaging in the prone position ha
Revealing turning points in ecosystem functioning over the Northern Eurasian agricultural frontier
Dysregulation of CXCR3 expression on peripheral blood leukocytes in patients with neovascular age-related macular degeneration
Amine-β-cyclodextrin-based nanosponges. The role of cyclodextrin amphiphilicity in the imidacloprid uptake
This paper describes the synthesis, characterization and sorption performance of cyclodextrin nanosponges (NSs). Cyclodextrins are cyclic oligosaccharides with remarkable amphiphilic properties, allowing for a vast range of applications. The synthesis of nanosponges of β-cyclodextrins was carried out using two uncommon cross-linkers: hexane-1,6-diamine (am6) and dodecane-1,12-diamine (am12). It ha
