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A major barrier for cancer immunotherapy is the presence of suppressive cell populations in patients with cancer, such as myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM), which contribute to the immunosuppressive microenvironment that promotes tumor growth and metastasis. Tasquinimod is a novel antitumor agent that is currently at an advanced stage of clinical develo

Background: FAD dependent glucose dehydrogenase (GDH) currently raises enormous interest in the field of glucose biosensors. Due to its superior properties such as high turnover rate, substrate specificity and oxygen independence, GDH makes its way into glucose biosensing. The recently discovered GDH from the ascomycete Glomerella cingulata is a novel candidate for such an electrochemical applicat

A 3D model is developed to describe an anode-supported planar solid oxide fuel cell (SOFC), by ANSYS/Fluent evaluating reactions including methane steam reforming (MSR)/water-gas shift (WGSR) reactions in thick anode layer and H-2-O-2/CO-O-2 electrochemical reactions in anode active layer, coupled with heat, mass species, momentum, and ion/electron charges transport processes in SOFC. The predicte

Caveolae and lipid rafts are plasma membrane microdomains that are considered to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth muscle function. Ca2+-sensitization is a contractile process depending on inhibition of myosin phosphatase

Assessment of clinical risk factors for haemorrhagic complications in patients undergoing intra-arterial thrombolysis for lower limb ischaemia. Retrospective reviews of consecutive patients subjected to intra-arterial thrombolysis due to lower limb ischemia at the Vascular Center, Malmö University Hospital, during a 5-year period from 2001 to 2005. Two hundred and twenty intra-arterial thrombolyti

Popular Abstract in Swedish Denna avhandling består av en undersökning av den litterära formen och den litterära kompositionen hos Johannes Klimakos Stege, samt en studie av hur författaren använder traditionen för att undervisa sin läsare. Förutom en kort introduktion och en genomgång av tidigare forskning, omfattar avhandlingen fyra kapitel. I det första kapitlet visas, utifrån ett antal detaljThis thesis offers an investigation of the literary form and the literary composition of The Ladder by John Climacus, as well as a study of how the author uses the tradition to form his reader. Besides a brief introduction with a survey of the previous research, the study comprises four chapters. In the first chapter it is shown, from a number of detailed text analyses, that the material in the s

In this thesis, the importance of cobalt and humic substances of terrestrial origin for the growth of some bloom-forming marine phytoplankton species is examined. Cobalt (Co) is considered an essential and potentially limiting trace metal for phytoplankton growth and is needed for the synthesis of vitamin B12. Since Co can be mobilised from soils at low pH values, acidification may have led to an

Video content constitutes a large share of residential Internet traffic. The major source of video content as of today is YouTube. In this paper, we analyse the user demand patterns for YouTube in two metropolitan access networks with more than 1 million requests over three consecutive weeks in the first network and more than 600,000 requests over four consecutive weeks in the second network. In p

Popular Abstract in Swedish Människan har under mycket lång tid använt enzymer vid tillverkning av livsmedel, bland annat vid syrning av mjölk, jäsning av bröd och bryggning av öl och vin. Man använde sig då av hela levande organismer och först på slutet av 1800-talet kunde den aktiva substansen isoleras. Dessa aktiva substanser fick samlingsnamnet enzym, vilket kommer från grekiska och betyder "iThe influence of different reaction parameters on enzyme selectivity was investigated. The reaction conditions studied were solvent dependence, water activity and reaction temperature. The improved selectivity was observed as higher synthetic yields in a-chymotrypsin and subtilisin catalyzed peptide synthesis respectively, and as higher enantioselectivity in the asymmetric reduction of ketones cat

Popular Abstract in Swedish Det finns en rad situationer då celler, företrädesvis nervceller, i hjärnan dör till följd av en kraftigt begränsad eller helt förhindrad blodtillförsel sk. ischemi. Till dessa hör "Stroke" eller slaganfall. Skallskada, drunkningsolyckor eller hjärtstopp med återupplivning, och hypoglykemi vid insulinkoma är ytterligare några fall där energi- eller syrgastillförseln är

Popular Abstract in Swedish Cytokromer bär hem som prostetisk grupp och ingår i den energi givande andningskedjan. Cytokromer namnges beroende på strukturen av den hem-molekyl som respektive cytokrom bär. Cytokrom av a-typ innehåller hemA, cytokrom av b-typ innehåller hemB osv. Cytokrom av c-typ skiljer sig från övriga cytokrom genom att ha hemgruppen kovalent bunden till proteinet. Syntes av baktCytochromes function in electron transfer reactions, e.g. in respiratory systems, and contain haem as a prosthetic group. Cytochromes of the c-type differ from other cytochromes in that haem is covalently attached, via thioether linkages, to two cysteine residues in a conserved sequence motif in the protein, Cys-Xaa-Yaa-Cys-His. The functional location of c-type cytochromes in bacteria is on the o