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The Upper Paraná River Basin (UPRB) has undergone remarkable land use and cover changes (LUCC) in recent decades. This paper analyses the hydrologic response to LUCC in the UPRB between 1985 and 2015, using the Soil and Water Assessment Tool (SWAT) model. The impacts of LUCC were examined for annual, wet, and dry season (both during calibrated and validated periods) between 1984 and 2015. The most
Background: The COVID-19 pandemic presents great challenges on transmission prevention, and rapid diagnosis is essential to reduce the disease spread. Various diagnostic methods are available to identify an ongoing infection by nasopharyngeal (NPH) swab sampling. However, the procedure requires handling by health care professionals, and therefore limits the application in household and community s
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. The pathophysiological mechanisms leading to low platelet levels in ITP have not been resolved, but at least involve autoantibody-dependent and/or cytotoxic T cell mediated platelet clearance and impaired megakary-opoiesis. In addition, T cell imbalances involving T regulatory cells (Tregs) also appear to play an important role. Int
As global warming is proceeding due to rising greenhouse gas concentrations, the Earth system moves towards climate states that challenge adaptation. Past Earth system states are offering possible modelling systems for the global warming of the coming decades. These include the climate of the mid-Pliocene (∼ 3 Ma), the last interglacial (∼ 129-116 ka) and the mid-Holocene (∼ 6 ka). The simulations
This paper gives a brief overview of the Gaia Research for European Astronomy Training (GREAT) network, including a description of the GREAT-ESF Research Network Programme and the GREAT Initial Training Network (GREAT-ITN). Scientific highlights from the GREAT-ITN are noted.
BACKGROUND: Women living in the Bolivian Andes are environmentally exposed to arsenic, yet there is scarce information about arsenic-related effects in this region. Several biomarkers for telomere length and oxidative stress (mitochondrial DNA copy number, mtDNAcn; 8-Oxo-2'-deoxyguanosine, 8-oxo-dG; and 4-hydroxy nonenal mercapturic acid, 4-HNE-MA) have been previously linked to arsenic, and some
BACKGROUND AND OBJECTIVES: Human genetic studies support a key role of interleukin-6 (IL-6) in the pathogenesis of ischemic stroke. Still, there are only limited data from observational studies exploring circulating IL-6 levels as a risk factor for ischemic stroke. Here, we set out to perform a systematic review and meta-analysis of aggregate data on cohort studies to determine the magnitude and s
In the recent Internet-of-Things (IoT) era where biomedical applications require continuous monitoring of relevant data, edge computing keeps gaining more and more importance. These new architectures for edge computing include multi-core and parallel computing capabilities that can enable prevention diagnosis and treatment of diseases in ambulatory or home-based setups. In this article, we explore
Multi-stimulus responsive poly(2-(2-methoxyethoxy)ethyl methacrylate-co-2-(diethylamino)ethyl methacrylate) [P(MEO2MA-co-DEA)] 80:20 mol % copolymer brushes were synthesized on planar silica substrates via surface-initiated activators continuously regenerated via electron transfer atom transfer radical polymerization. Brush thickness was sensitive to changes in pH and temperature as monitored with
Current syntheses of CsPbBr3 halide perovskite nanocrystals (NCs) rely on overstoichiometric amounts of Pb2+ precursors, resulting in unreacted lead ions at the end of the process. In our synthesis scheme of CsPbBr3 NCs, we replaced excess Pb2+ with different exogenous metal cations (M) and investigated their effect on the synthesis products. These cations can be divided into two groups: group 1 d
IntroductionPatients with congenital heart disease (ConHD) are at increased risk for adverse cardiac events. Predicting long-term outcomes and guidance of patient management might benefit from a range of (new) biomarkers. This is a rapidly evolving field with potentially large consequences for clinical decision making. With a systematic review of available biomarkers in ConHD we identified the cli
This study investigated the presence of MPs in three species of bivalves cultivated in Brazil: Crassostrea gigas, Perna perna, and Nodipecten nodosus. Our hypothesis was that the different structures and plastic materials used in the cultivation of these bivalves could serve as a contributing source of MPs. Our results showed the presence of MPs in all species, with C. gigas showing the highest le
BACKGROUND: Recent advancements in Alzheimer's disease (AD) biomarker research and clinical trials prompt reflection on the value and consequently appropriate use of tau positron emission tomography (tau-PET) in the future. METHODS: We conducted an online survey among dementia and PET experts worldwide to investigate the anticipated future role of tau-PET in clinical practice and trials. RESULTS:
Background: Stroke is one of the major chronic non-communicable diseases (NCDs) with high morbidity, disability and mortality. The key to preventing stroke lies in controlling risk factors. However, screening risk factors and quantifying stroke risk levels remain challenging. Methods: A novel prediction model for stroke risk based on two-level feature selection and deep fusion network (SRPNet) is
Novel coordinatively saturated platinum(ii) compounds bearing C-linked carbohydrates were synthesized and characterized. The complexes exhibit bipyramidal trigonal geometry with a bidentate nitrogen ligand and ethylene in the equatorial plane. The axial positions are occupied by a halide ligand X and a d-galactose or d-glucose derivative, linked either via C1 or C6. The compounds were designed for
This paper examines the development of the Artificial Intelligence (AI) meta-debate in Sweden before and after the release of ChatGPT. From the perspective of agenda-setting theory, we propose that it is an elite outside of party politics that is leading the debate – i.e. that the politicians are relatively silent when it comes to this rapid development. We also suggest that the debate has become This paper examines the development of the Artificial Intelligence (AI) meta-debate in Sweden before and after the release of ChatGPT. From the perspective of agenda-setting theory, we propose that it is an elite outside of party politics that is leading the debate – i.e. that the politicians are relatively silent when it comes to this rapid development. We also suggest that the debate has become
Plesiosaurs are an iconic group of Mesozoic marine reptiles with an evolutionary history spanning over 140 million years (Ma).1 Their skeletal remains have been discovered worldwide; however, accompanying fossilized soft tissues are exceptionally rare.2 Here, we report a virtually complete plesiosaur from the Lower Jurassic (∼183 Ma)3 Posidonia Shale of Germany that preserves skin traces from arou
Peritoneal dialysis (PD) is a kidney replacement therapy for patients with end-stage renal disease. It is becoming more popular as a result of a rising interest in home dialysis. Its effectiveness depends on several physiological and technical factors, which have led to the development of various computational models to better understand and predict PD outcomes. In this review, we traced the evolu
