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Natural climate oscillations can cause extreme events such as floods and droughts. The mid-1970s is known for the occurrence of a global Climate Shift, defined as a short period when both interannual and interdecadal climate oscillations changed phases, which led the climate to a new state. Climate Shift has affected many regions and is considered an unprecedented event. In this chapter, we descri
This chapter examines the evolution of social class segregation in the city of Landskrona during the twentieth century. The city’s population was initially spatially mixed with regards to social class but became more segregated with industrialization. The study reveals that the segregation of higher white-collar workers increased drastically from 1940 to 1960, with a concentration of this group in
This paper examines the origins of formal education in colonial Zambia and its long-term consequences for educational attainment and gender inequality. Combining novel panel data on the location of missionary stations and mission school enrolment by gender and missionary society from 1924 to 1953 with contemporary data from the 1990 Zambian census, we ana-lyze the long-term effects of missionary e
This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state-of-the-art protocols for the preparation, phenotype analysis by flow cytometry, generation, fluorescence microscopy, and functional characterization of mouse and human dendritic cells (DC) from lymphoid organs, and various nonlymphoid tissues. Within this article, detailed protocols are prese
There is currently a great need for rigid, high-performance and processable bio-based polymers and plastics as alternatives to the fossil-based materials used today. Here, we report on the straightforward synthesis and polymerization of lignin-derived methacrylate monomers based on the methyl esters of syringic, vanillic, and 4-hydroxybenzoic acid, respectively. The corresponding homopolymethacryl
New particle formation via the ion-mediated sulfuric acid and ammonia molecular clustering mechanism remains the most widely observed and experimentally verified pathway. Recent laboratory and molecular level observations indicate iodine-driven nucleation as a potentially important source of new particles, especially in coastal areas. In this study, we assess the role of iodine species in particle
We previously showed that SerpinE2 and the serine protease HtrA1 modulate fibro-blast growth factor (FGF) signaling in germ layer specification and head-to-tail development of Xenopus embryos. Here, we present an extracellular proteolytic mechanism involving this serpin-protease system in the developing neural crest (NC). Knockdown of SerpinE2 by injected antisense morpholino oligonucleotides did
This paper investigates the aeroacoustic properties of dual-stream co-axial supersonic jets, focusing on sound generation at the engine nozzle exit, which significantly contributes to cabin noise in supersonic civil aviation. The study delves into three primary noise-generating mechanisms present in supersonic jets: broadband shock-associated noise, jet screech, and turbulent mixing noise. While s
BACKGROUND: Despite much debate, there is little evidence on consequences of consent procedures for residual tissue use. Here, we investigated these consequences for the availability of residual tissue for medical research, clinical practice, and patient informedness.METHODS: We conducted a randomised clinical trial with three arms in six hospitals. Participants, patients from whom tissue had been
Over the past decades, the growing proliferation of international institutions governing the global environment has impelled institutional interplay as a result of functional and normative overlap across multiple regimes. This article synthesizes primary contributions made in research on institutional interplay over the past twenty years, with particular focus on publications with International En
Food additives (e.g. artificial sweeteners, emulsifiers, dyes, etc.) are ingested by billions of individuals daily. Some concerning results, mainly derived from animal and/or cell-based experimental studies, have recently emerged suggesting potential detrimental effects of several widely consumed additives. Profiles of additive exposure as well as the potential long-term impact of multiple exposur
We describe the outcome of a data challenge conducted as part of the Dark Machines (https://www.darkmachines.org) initiative and the Les Houches 2019 workshop on Physics at TeV colliders. The challenged aims to detect signals of new physics at the Large Hadron Collider (LHC) using unsupervised machine learning algorithms. First, we propose how an anomaly score could be implemented to define model-
BACKGROUND: Per-and polyfluoroalkyl substances (PFAS) are widespread and persistent pollutants that have been associated with elevated cholesterol levels. However, data on incident cardiovascular disease (CVD) is lacking. OBJECTIVES: We investigated the association of exposure to PFAS with risk of myocardial infarction and stroke and, subsidiary, with baseline blood lipids. METHODS: This populatio
A 27-years-old female with multiple autoimmune disorders presented to our cardiology unit for acute chest pain and worsening dyspnoea. Admission blood tests revealed increased serum levels of high-sensitive cardiac troponin, eosinophilic count and C-reactive protein. Laboratory findings, low QRS voltages by ECG, mildly reduced left ventricular systolic function in the context of pseudohypertrophy,
Wavelet approaches have been successfully applied to the detection of brain activity in fMRI data. Spatial activation patterns have a compact representation in the wavelet domain. However, classical wavelets designed for regular Euclidean spaces are not optimal for the topologically complicated gray-matter (GM) domain where activation is expected. We hypothesized that wavelet bases that are adapte
Objective. The aim was to theoretically and experimentally investigate recovery in SPECT images with objects of different shapes. Furthermore, the accuracy of volume estimation by thresholding was studied for those shapes. Approach. Nine spheres, nine oblate spheroids, and nine prolate spheroids phantom inserts were used, of which the six smaller spheres were part of the NEMA IEC body phantom and
