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Congenital muscular dystrophy with laminin α2 chain-deficiency (MDC1A) is one of the most severe forms of muscular disease and is characterized by severe muscle weakness and delayed motor milestones. The genetic basis of MDC1A is well-known, yet the secondary mechanisms ultimately leading to muscle degeneration and subsequent connective tissue infiltration are not fully understood. In order to obt
High resolution real time heat release analysis will become increasingly important in the future development of engine control systems. The increased demands on efficiency and emissions will put high demands on future engine control. Future engine concepts, for example the HCCI engine concept might crave cylinder pressure based Closed-Loop Combustion Control (CLCC). The analysis of cylinder pressu
The aim of this paper is to chart the relevant studies and research questions concerning the relationship between ICTs and Mobility in Everyday Life – a concept defined and delineated in a previous paper An Agenda for ‘Mobility in Everyday Life’ for ICT Researchers (Haddon, 2000a).
An experiment has been performed to search for superdeformed (SD) states in Dy-149,Dy-150. While no evidence for discrete superdeformed states has been observed, a superdeformed ridge with a separation of Delta E-gamma=52 keV with a total intensity of 1.8+/-0.5% that of Dy-150 has been observed. An upper limit of 0.8% (0.9%), of the intensity of Dy-150 (Dy-149), is placed for observation of the mo
Aim: To investigate whether there is any pharmacokinetic rationale for the common practice of administering vincristine to adolescents at relatively lower doses than those to younger children. Methods: A total of 98 children, aged 1.3-17.3 y, with acute lymphoblastic leukaemia (ALL) were studied on day I of induction therapy. Plasma samples were drawn before and 10, 30, 360 and 1380 min after inje
We consider the log-likelihood function of hidden Markov models, its derivatives and expectations of these (such as different information functions). We give explicit expressions for these functions and bound them as the size of the chain increases. We apply our bounds to obtain partial second order asymptotics and some qualitative properties of a special model as well as to extend some results
BACKGROUND: -Atrial fibrillatory rate (AFR) is a measure of atrial remodeling caused by atrial fibrillation (AF) and its acceleration negatively affects outcome of interventions for persistent AF. However, the prognostic value of AFR in patients with CHF has not been studied. We sought to evaluate whether AFR can predict outcome in patients with mild to moderate (NYHA II-III) congestive heart fail
Background: Poly-3-d-hydroxybutyrate (PHB) that is a promising precursor for bioplastic with similar physical properties as polypropylene, is naturally produced by several bacterial species. The bacterial pathway is comprised of the three enzymes β-ketothiolase, acetoacetyl-CoA reductase (AAR) and PHB synthase, which all together convert acetyl-CoA into PHB. Heterologous expression of the pathway
Sustainable and efficient management of a distribution system requires coordination between transportation planning and inventory control decisions. In this context, we consider a one warehouse multi-retailer inventory system with a time-based shipment consolidation policy at the warehouse. This means that there are fixed costs associated with each shipment, and retailer orders are consolidated an
In this paper, we have investigated, by means of quantitative and statistical methods, stability and change in cultural vocabulary of Indo-European in Europe, with a focus on agriculture. For this purpose we have created a culture vocabulary list with lexical head words, organized into subcategories based on their role and function in a cultural system, the purpose of which is to give a representa
Intraspecific variation can have important consequences for the structure and function of ecological communities, and serves to link community ecology to evolutionary processes. Differences between the sexes are an overwhelmingly common form of intraspecific variation, but its community-level consequences have never been experimentally investigated. Here, we manipulate the sex ratio of a sexually
Friction stir welding (FSW) is a solid-state welding process where metals are joined without melting. Heat is generated by friction between a rotating non-consumable tool and the work-piece material, and by mechanical deformation of the material. The process, invented in 1991, provides several benefits over arc welding and other fusion processes: No filler material has to be added, low energy cons
In Islamic Modernities in Southeast Asia, Leonie Schmidt provides a thorough analysis of contemporary Islamic-themed popular and visual cultures, mainly in Indonesia. This book is an essential read for those who wish to understand multiple modernities unfolding in post-1998 Indonesia (the Reformasi era). By using the term Islamic, she refers to any ‘cultural practices that are considered bernafask
Examples are given that modify some oversimplified statements usually made about the motion of robots in singular configurations. A robot may be controlled in an arbitrary direction from a singular configuration if the velocity profiles are shaped in a proper way. The observations on possible motions open a number of questions, since a wider class of motions is possible that at first sight. Hence,
Western flower thrips, Frankliniella occidentalis (Pergande) (Thysanoptera: Thripiclae), cause very large economic damage on a variety of field and greenhouse crops. In this study, plant resistance against thrips was introduced into transgenic potato plants through the expression of novel, custom-made, multiclomain protease inhibitors. Representative classes of inhibitors of cysteine and aspartic
BACKGROUND: Diagnostic methods for the study of allergic reactions to Anisakis simplex (A.s.) based on whole-body extracts of the larva are clearly insufficient. OBJECTIVES: To study the allergenicity of the proteins secreted by the parasite. Comparison with somatic antigens and determination of their clinical importance in allergic patients were also addressed. METHODS: An excretory/secretory (E/
Background Cardiovascular autonomic dysfunction is associated with increased incidence of cardiovascular diseases (CVD). This population-based study explored whether low FEV(1) or low vital capacity (VC) is associated with autonomic dysfunction, as measured by the spontaneous heart rate variability (HRV) and systolic BP variability (SBPV). Methods SBPV and HRV were recorded during 5 min of control
To study gene expression in differentiated adult motoneuron subtypes, we used fluorescent dextrans for both anterograde and retrograde axonal tracing in adult rat and mouse. Application of these dyes to the cut distal and proximal ends of small extramuscular nerve branches revealed both the peripheral ramifications and the cell bodies of subsets of motoneurons. We show that the soleus muscle is in
Det är allmänt känt att kontinenter under Jordens historia har separerat och kolliderat i ett cykliskt förlopp vilket har lett till existensen av större landmassor, superkontinenter eller superkratoner under vissa tidsperioder. En av de tidigaste föreslagna superkratonerna är Vaalbara, som sedan 1960-talet har ansetts bestå av Kaapvaalkratonen i södra Afrika och Pilbarakratonen i västra AustralienIn this thesis, the longevity and continuity of the Vaalbara supercraton is addressed in six papers aimed at placing new temporal and spatial constraints onthe supercraton in the Mesoarchean to Paleoproterozoic. It has been speculated since the 1960’s that the Kaapvaal Craton in southern Africa, together withthe Pilbara Craton in Western Australia existed as a single landmass during the Precambria
