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Background: CD40 agonists have the potential to enhance the efficacy of standard of care chemotherapy and to trigger antitumor immunity. Preclinical models indicate that the success of this approach depends on appropriate sequencing of chemotherapy with a CD40 agonist. Preliminary efficacy results from the OPTIMIZE-1 Phase II study (NCT04888312) combining mitazalimab (anti-CD40) with mFFX chemothe
Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal d
En kvalitativ fallstudie där vi med hjälp av öppna personliga intervjuer talat med folk iledande befattningar på vårt fallföretag Procurator AB för att forma oss en bild av den strategiska förändring företaget genomgått de senaste tio åren. För att kunna beskriva de den förändring som Procurator genomgått under dessa år har vi identifierat tre nya begrepp, semidiversifiering, partiell diversifieri
Tracking of rigid and articulated objects is usually addressed within a particle filter framework or by correspondence based gradient descent methods. We combine both methods, such that (a) the correspondence based estimation gains the advantage of the particle filter and becomes able to follow multiple hypotheses while (b) the particle filter becomes able to propagate the particles in a better ma
The two isoforms of glutamic acid decarboxylase (GAD), GAD67 and GAD65, synthesize the neurotransmitter γ-aminobutyric acid in neurons and pancreatic β-cells. Previous studies suggest that GAD67 is a soluble cytosolic protein, whereas GAD65 is membrane-associated. Here we study the intracellular distribution of GAD67 in neurons, pancreatic β-cells, and fibroblasts transfected either with GAD65 and
The end-Triassic mass extinction (c. 201.6 Ma) was one of the five largest mass-extinction events in the history of animal life. It was also associated with a dramatic, long-lasting change in sedimentation style along the margins of the Tethys Ocean, from generally organic-matter-poor sediments during the Triassic to generally organic-matter-rich black shales during the Jurassic. New core material
Gamow-Teller β decay is forbidden if the number of nodes in the radial wave functions of the initial and final states is different. This Δn=0 requirement plays a major role in the β decay of heavy neutron-rich nuclei, affecting the nucleosynthesis through the increased half-lives of nuclei on the astrophysical r-process pathway below both Z=50 (for N>82) and Z=82 (for N>126). The level of forbidde
The political and institutional crisis in Brazil from 2015, fueled largely by corruption probes and lawfare, had severe repercussions within the Brazilian construction and energy sectors. While many international investors withdrew from Brazil in this period, Chinese investment surged. This article accounts for the particular characteristics of Chinese investments, such as sectorial complementarit
Ett detta kapitel som behandlar sociala rättigheter i ett domstolssammanhang analyseras domstolars betydelsefulla roll när det gäller att uttolka och använda begreppet skälig levnadsnivå, som ett sätt att både omförhandla och utveckla rättigheter.
This thesis investigates electronic transport in several types of novel heterostructure nanowires. The first part of the thesis focuses on band-to-band mechanisms in heterostructure nanowires for low-power electronics. First, tunnel field-effect transistors (TFETs) based on InP/GaAs heterostructure nanowires with n-i-p doping profile are explored. To further enhance the interband tunneling current
The attention to the environmental impact of plastics materials used in food packaging has produced several studies in the last decade and consumers have started wondering about the utility and the functions of food packaging. In fact, the use and the production of plastic polymers cause pollution due to the disposal and to the CO2 emission. Besides that, even if new polymers from organic and biol
Syftet med skattereformen 1990/91 var sänkta skattesatser, minskad progressivitet och en mer enhetlig beskattning överlag. Systemet skulle dessutom vara både enkelt att tillämpa och enkelt att överblicka samtidigt som långsiktighet och stabilitet eftersträvades. Efter ikraftträdandet har ett antal ändringar företagits samtidigt som samhället har förändrats vilket har inneburit att målen vad avser
