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Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation of the hepatic low-density lipoprotein receptor (LDL-R) and is therefore a prominent therapeutic target for reducing LDL-cholesterol. The C-terminal domain of PCSK9 is unlikely to be involved in a direct extracellular interaction with the LDL-R. We probed the importance of the C-terminus for the degradation of the LDL-R
Evaluation of anti-proliferative effect of BSA-1 and 32/26/2B in Y79 retinoblastoma cancer cells.
This investigation deals with the debate surrounding the controversial question of whether there exists a constitutive tradition at the Second Vatican Council (1962-1965). The investigation can broadly be divided into three sections. The first section provides both an analysis of the terminology relevant for understanding and a theological background. The background leads up the Council of Trent (
Uppsatsen behandlar lagstiftningsprocessen bakom införandet av den nya bestämmelsen i 24 kap 19 a § IL, som utgör en del av de riktade ränteav-dragsbegränsningsreglerna. Syftet är att analysera vilka intressen som har haft störst genomslag vid utformningen av bestämmelsen samt att bedöma om den nya regeln är förenlig med EU-rätten, särskilt mot etableringsfriheten och EU-domstolens praxis gällande
The aim of this study is to examine how the need for belonging and search for an identity manifest themselves in the autobiographical works of two gay contemporary writers: Abdellah Taïa and Édouard Louis. Both authors have, during their childhood and adolescence, been confronted with a society that tried to exclude them for being ‘different’ and not fitting in the heterosexual norm. Suddenly, the
Senior lecturer Contact details Email: andres [dot] palacio [at] ekh [dot] lu [dot] se Phone: +46 46 222 01 51Organisation Department of Economic History Visiting address: Scheelevägen 15 B, Lund Room number: Alfa 1:2057 Service point: 10 WebpageAndrés Palacios profile in Lund University research portalOther affiliations Senior lecturer Economic demography Researcher Centre for Advanced Middle Eas
https://www.lusem.lu.se/andres-palacio - 2026-07-09
Den första oktober 2019 infördes med SFS 2019:523 en lång rad lagändringar i hyreslagen. Till de viktigaste ändringarna hör 1) kriminalisering av köpare av hyreskontrakt, 2) skärpta straff för försäljning av hyreskontrakt, 3) kriminalisering av andrahandsuthyrning om hyresgästen både saknar tillstånd från hyresvärd eller hyresnämnd och tar ut ett överpris och 4) att hyresrätter inte längre kan bytOn 1 October 2019 SFS 2019:523 was entered into action, containing a long list of legal changes in the Swedish Rent Act (Hyreslagen). Among the more prominent changes were i) the criminalization of buyers of a rental contract, ii) harsher punishment for selling such contracts, iii) criminalization of tenants who both sublet the apartment without permission from the landlord or the Rental Board and
Gräsrotsfinansiering är en växande alternativ finansieringsform, både i Sverige och internationellt. Finansieringsformen kännetecknas av att många investerare tillsammans investerar en relativt liten men totalt sett betydande summa kapital i en affärsidé eller ett projekt. Andelsbaserad gräsrotsfinansiering är en variant av gräsrotsfinansiering som innebär att investeraren erhåller andelar i det iCrowdfunding is a growing alternative form of financing, both in Sweden and internationally. This form of financing is characterized by the fact that many investors together invest a relatively small but overall significant amount of capital in a business idea or project. Equity crowdfunding is a variant of crowdfunding which means that the investor acquires shares in the invested company in. The
The importance of the historical contacts between mainland Finland and the island of Gotland has long been overlooked. The purpose of this analysis is therefore to focus on the contacts between these two areas during a period when cultural and material exchange was of utmost importance, the Viking Age. A common jewellery type used by the Finnish women during the whole Viking Age period were the c
The Sweden Democrats achieved great progress in the latest election in the Swedish municipals. The party is now closer than ever concerning reaching the Swedish parliament. This thesis examines the Sweden Democrats in the Swedish municipals with the aim to find out which municipal factors that led to their progress. By looking at the percentage share of unemployment, the percentage share of foreig
The purpose of our study is to examine what risk factors can contribute to a child/youth with neuropsychiatric disorders developing an addiction to drugs. We also wanted to find out what protective factors can contribute not to develop an addiction. In order to find out these two different aspects we interviewed twelve professionals to get their view upon the matter. The professionals work within
Checkpoints er fremtrædende og helt uomgængelige i nye syriske romaner skrevet i krigsårene. Checkpoint(s) (ḥājiz – pl. ḥawājiz) er en del af det nye litterære ordforråd efter 10 år med opstand og konflikt. Checkpointene er centrale elementer i de landskaber historierne udspiller sig i, de styrer den narrative struktur og tydeliggør væsentlige temaer i den tilværelse i krig, litteraturen fremstillCheckpoints are prominent and completely unavoidable in new Syrian novels depicting the war years. Checkpoint (s) (ḥājiz / ḥawājiz) are part of the new literary vocabulary after ten years of revolt and conflict. The checkpoints are central elements in the landscapes in which the stories take place, they guide the narrative structure, and accentuate essential themes in the life in war. Confrontatio
