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Molecular alterations associated with liver metastases development in colorectal cancer patients

BACKGROUND: Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predict liver metastases.METHODS: Formalin-fixed paraffin-embedded material from prim

Challenging the dogma of colorectal peritoneal metastases as an untreatable condition : Results of a population-based study

PURPOSE: To determine the impact of the implementation of novel systemic regimens and locoregional treatment modalities on survival at population level in colorectal cancer (CRC) patients presenting with peritoneal metastases (PMs).METHODS: All consecutive CRC patients with synchronous PM (<3 months) between 1995 and 2014 were extracted from the Eindhoven area of the Netherlands Cancer Registry. T

Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer

PURPOSE: To confirm the findings from uncontrolled studies that aggressive cytoreduction in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) is superior to standard treatment in patients with peritoneal carcinomatosis of colorectal cancer origin.PATIENTS AND METHODS: Between February 1998 and August 2001, 105 patients were randomly assigned to receive either standard treatment co

Quality assessment of radiotherapy in the prospective randomized SENOMAC trial

Background and purpose: Recommendations for regional radiotherapy (RT) of sentinel lymph node (SLN)-positive breast cancer are debated. We here report a RT quality assessment of the SENOMAC trial. Materials and Methods: The SENOMAC trial randomized clinically node-negative breast cancer patients with 1–2 SLN macrometastases to completion axillary lymph node dissection (cALND) or SLN biopsy only be

MiDAS 5 : Global diversity of bacteria and archaea in anaerobic digesters

Anaerobic digestion of organic waste into methane and carbon dioxide (biogas) is carried out by complex microbial communities. Here, we use full-length 16S rRNA gene sequencing of 285 full-scale anaerobic digesters (ADs) to expand our knowledge about diversity and function of the bacteria and archaea in ADs worldwide. The sequences are processed into full-length 16S rRNA amplicon sequence variants

The role of echocardiography in sports cardiology : An expert opinion statement of the Italian Society of Sports Cardiology (SIC sport)

Transthoracic echocardiography (TTE) is routinely required during pre-participation screening in the presence of symptoms, family history of sudden cardiac death or cardiomyopathies <40-year-old, murmurs, abnormal ECG findings or in the follow-up of athletes with a history of cardiovascular disease (CVD). TTE is a cost-effective first-line imaging modality to evaluate the cardiac remodeling due to

A temporal developmental map separates human NK cells from noncytotoxic ILCs through clonal and single-cell analysis

Natural killer (NK) cells represent the cytotoxic member within the innate lymphoid cell (ILC) family that are important against viral infections and cancer. Although the NK cell emergence from hematopoietic stem and progenitor cells through multiple intermediate stages and the underlying regulatory gene network has been extensively studied in mice, this process is not well characterized in humans

Hybrid speciation driven by multilocus introgression of ecological traits

Hybridization allows adaptations to be shared among lineages and may trigger the evolution of new species1,2. However, convincing examples of homoploid hybrid speciation remain rare because it is challenging to demonstrate that hybridization was crucial in generating reproductive isolation3. Here we combine population genomic analysis with quantitative trait locus mapping of species-specific trait

Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state

Aims CD40 and its ligand, CD40L, play a critical role in driving atherosclerotic plaque development. Disrupted CD40-signalling reduces experimental atherosclerosis and induces a favourable stable plaque phenotype. We recently showed that small molecule-based inhibition of CD40-tumour necrosis factor receptor associated factor-6 interactions attenuates atherosclerosis in hyperlipidaemic mice via ma

Tau-neurodegeneration mismatch reveals vulnerability and resilience to comorbidities in Alzheimer's continuum

INTRODUCTION: Variability in relationship of tau-based neurofibrillary tangles (T) and neurodegeneration (N) in Alzheimer's disease (AD) arises from non-specific nature of N, modulated by non-AD co-pathologies, age-related changes, and resilience factors. METHODS: We used regional T-N residual patterns to partition 184 patients within the Alzheimer's continuum into data-driven groups. These were c

Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling

Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic breast cancer, in particular to aromatase inhibitors. ESR1 mutations promote constitutive ER activity and affect other signaling pathways, allowing cancer cell

CD44v6 is associated with tumor aggressiveness and chemoresistance in bladder cancer

Bladder cancer is a fast-moving and recurrent malignancy where survival hinges on early detection and precise risk stratification. The search for robust biomarkers is urgent, and CD44v6 has emerged as a compelling candidate. In this study, we explored the clinical and functional associations of CD44v6 expression in bladder cancer. Integrated analyses of patient samples and cell lines showed that h

REPORT TITLE

REPORT TITLE 1 Report of the RWI Afghanistan Programme Kobra Moradi Raoul Wallenberg Institute of Human Rights and Humanitarian Law “Throwing Dust in Our Eyes”: Nomadic-Sedentary Land Conflict in Hazarajat under the Taliban and Its Human Rights Impacts 0 The copyright of the Raoul Wallenberg Institute of Human Rights and Humanitarian Law (RWI) Illustrations included in the publication are the work

https://rwi.lu.se/wp-content/uploads/2025/05/Kobra-Moradi-2025-Throwing-Dust-in-Our-Eyes.pdf - 2026-05-31

Anmälningsanvisningar För Läsåret 2024-2025[1]

Lunds universitets anmälningsanvisningar 2023-09-05 Dnr STYR 2023/1470 Antagningsnämnden Lunds universitets anmälningsanvisningar Innehåll Lunds universitets anmälningsanvisningar ......................................................................... 1 Så här anmäler du dig .......................................................................................................... 3 När du anmäle

https://www.staff.lu.se/sites/staff.lu.se/files/2023-09/Anm%C3%A4lningsanvisningar%20f%C3%B6r%20l%C3%A4s%C3%A5ret%202024-2025%5B1%5D.pdf - 2026-05-31

Conference Abstracts 2024

1 CONFERENCE ABSTRACTS Lund University Research Conference KNOWLEDGE FOR SUSTAINABLE DEVELOPMENT 4 DECEMBER 2024 | STADSHALLEN, LUND Session I - 11:00-11:30 - I Regulation, policy and responsibility - II Empowering people and organizations - III People at risk - IV Navigating global networks and circular economy Session II – 14:55-15:55 - I Natural resources - controversies and redefinitions - II

https://www.sustainability.lu.se/sites/sustainability.lu.se/files/2024-12/Conference%20abstracts%202024.pdf - 2026-05-31

Wp 7 2011 0

RESEARCH IN SERVICE STUDIES LUND UNIVERSITY, Campus Helsingborg Working paper No 7, Dec 2011 The Department of Service Management Tourist Camps The Ordering Power of All-inclusive Tourism Richard Ek Tourist Camps The Ordering Power of All-inclusive Tourism Richard Ek Department of Service Management, Lund University – Campus Helsingborg, Box 882, SE-251 08 Helsingborg, Sweden richard.ek@ism.lu.se

https://www.ses.lu.se/sites/ses.lu.se/files/wp_7_2011_0.pdf - 2026-05-31

CEC i media 2020

Ett axplock av artiklar och andra inslag i medier där forskare knutna till Centrum för miljö- och klimatforskning, CEC, har intervjuats. Så sammanställer FN:s klimatpanel IPCC läget för klimatet(6 december 2020)Markku Rummukainen intervjuades i Dagens Nyheters specialutgåva om klimat och biologisk mångfald, med Greta Thunberg som chefredaktör för dagen, om hur FN:s klimatpanel IPCC fungerar.Artike

https://www.cec.lu.se/sv/nyheter-och-media/cec-i-media/2020 - 2026-05-29

MastersDissertationColdBentGlass

MastersDissertationColdBentGlass Master’s Dissertation Structural Mechanics Report TV SM -5280 M O H A M A D BA RA D EY M O D ELLIN G O F C U R V ED G LA SS ELEM EN TS - C o ld -B en t G lass an d Sim p lifi ed M o d els MOHAMAD BARADEY MODELLING OF CURVED GLASS ELEMENTS Cold-Bent Glass and Simplifi ed Models DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN LUTVDG/TVSM--25

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5280.pdf - 2026-05-30

No title

Master’s Dissertation Structural Mechanics HENRIK DANIELSSON STRENGTH TESTS OF GLULAM BEAMS WITH QUADRATIC HOLES - TEST REPORT Copyright © 2008 by Structural Mechanics, LTH, Sweden. Printed by KFS i Lund AB, Lund, Sweden, March 2008. For information, address: Division of Structural Mechanics, LTH, Lund University, Box 118, SE-221 00 Lund, Sweden. Homepage: http://www.byggmek.lth.se Structural Mech

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm7000/web7153.pdf - 2026-05-31