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A semistructured personal interview was performed with 29 carriers of hemophilia A or B, 1-5 years after a pregnancy in which prenatal diagnosis (PND) was performed by fetal blood sampling. Fetal blood sampling by fetoscopy was significantly more often reported by the women to the more trying than expected than was ultrasound-guided heart puncture. Of 29 women 13 was classified as having experienc

The aim was to investigate clinical predictors of adherence to antipsychotics. Medication use was electronically monitored with a Medication Event Monitoring System (MEMS(®)) for 12 months in 112 outpatients with schizophrenia and schizophrenia-like psychosis according to DSM-IV. Symptom burden, insight, psychosocial function (PSP) and side effects were rated at baseline. A comprehensive neuropsyc

Background: Cystatin C is a major inhibitor of the elastin- and collagen-degrading cysteine proteases and may therefore have an important role in preserving atherosclerotic plaque stability. In this study we analyzed the associations between human carotid plaque cystatin C expression and the plaque content of collagen and elastin. Methods: Thirty-one plaques were removed by endarterectomy and homo

OBJECTIVE: We synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function. DATA SOURCES AND EXTRACTION: We used a database with interview and biological data from 2,269 women and their spouses, and 18 published core papers. DATA SYNTHESIS: The study did not provide direct evidence of hormone-like ac

BACKGROUND: The importance of genetic factors in the etiology of Hodgkin lymphoma (HL) has been suggested by family and population studies. However, the spectrum of malignancies associated with common genetic etiology and the effects of gender and age on familial risk have not been established.METHODS: Diagnoses of lymphoproliferative malignancies were compared in 15,799 first-degree relatives of

Carcinoids are rare neuroendocrine tumors, mainly located in the bowel, stomach and lung. Familial risks in carcinoid tumours are not well known apart from multiple endocrine neoplasia 1 (MEN1). We used the nation-wide Swedish Family-Cancer Database on 10.1 million individuals for assessment. Carcinoid tumors were retrieved from the Cancer Registry covering the years 1958-1998. The offspring gener

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, with ~40–50% of patients diagnosed with non-metastatic disease (stages IA–IIIC). The treatment landscape is evolving rapidly as immunotherapies and targeted therapy are introduced in the non-metastatic setting, creating a need to assess patient outcomes prior to their introduction. This real-world study usin

PIONEER is a European network of excellence for big data in prostate cancer consisting of 37 private and public stakeholders from 9 countries across Europe. Many progresses have been done in prostate cancer management, but unanswered questions in the field still exist, and big data could help to answer these questions. The PIONEER consortium conducted a two-round modified Delphi survey aiming at b

The YPEL family genes are highly conserved across a diverse range of eukaryotic organisms and thus potentially involved in essential cellular processes. Ypel4, one of five YPEL family gene orthologs in mouse and human, is highly and specifically expressed in late terminal erythroid differentiation (TED). In this study, we investigated the role of Ypel4 in murine erythropoiesis, providing for the f

SUMMARY: Fall prevention is a key strategy for reducing osteoporotic fractures. We investigated the association between vitamin D receptor (VDR) polymorphisms and reported falls in postmenopausal women. Bsm1 polymorphisms were associated with falls, balance and muscle power measurements. These results may explain some of the excess fracture risk associated with VDR in some studies.INTRODUCTION: Fa

Genetic studies of complex traits have become increasingly successful as progress is made in next-generation sequencing. We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. We used next-generation sequencing to identify si

Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown. We investigated the effects of asthma-associated SNPs on DNA methylation and mRNA levels of GSDMB and ORMDL3. Genetic association between GSDMB/ORMDL3 and physician

Background: Quality of life (QOL) has become an important complementary endpoint in cancer clinical studies alongside more traditional assessments (eg, tumour response, progression-free survival, overall survival). Niraparib maintenance treatment has been shown to significantly improve progression-free survival in patients with recurrent ovarian cancer. We aimed to assess whether the benefits of e

https://www.student.lth.se/english/exchange-students/preparing-for-your-studies/how-to-apply/ - 2026-05-25

Den här artikeln är över 5 år gammal, och informationen kan därför vara inaktuell. Forskare publicerar nya rön om validerade biomarkörer för individens risk att utveckla Alzheimers sjukdom. Med en modell som kombinerar nivåerna av två specifika proteiner i blodet hos personer med lättare minnessvårigheter kan forskarna förutsäga risken att utveckla alzheimerdemens på individnivå. Forskarna har äve

https://www.medicin.lu.se/artikel/biomarkorer-och-app-forutsager-individers-risk-utveckla-alzheimer - 2026-05-27

Den här artikeln är över 5 år gammal, och informationen kan därför vara inaktuell. Inbillning, sa man innan vi visste bättre. Jorddragning, magiska besvärjelser eller blåsa på barnets skrubbsår. Sådant lindrar väl inte smärta eller botar sjukdom. Sådant tillhör vidskepelsens tid, inte den moderna medicinens era. Ja, så sa man, men nu vet vi bättre. Nu vet vi att placeboeffekten är kraftfull, att d

https://www.diabetesportalen.lu.se/artikel/placebo-tankens-makt-over-kroppen - 2026-05-27

Den här artikeln är över 5 år gammal, och informationen kan därför vara inaktuell. ECT, eller elbehandling, är en behandling med god effekt för svårt deprimerade patienter. Men många patienter är oroliga för biverkningar, främst långvariga minnessvårigheter. Nu har forskare vid Lunds universitet i studier på möss undersökt om ECT påverkar halterna av proteinet beta-amyloid i hjärnan– det protein s

https://www.medicin.lu.se/artikel/ny-studie-pa-moss-om-ect-och-alzheimers-protein-visar-lugnande-resultat - 2026-05-27