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Background: Cystatin C is a major inhibitor of the elastin- and collagen-degrading cysteine proteases and may therefore have an important role in preserving atherosclerotic plaque stability. In this study we analyzed the associations between human carotid plaque cystatin C expression and the plaque content of collagen and elastin. Methods: Thirty-one plaques were removed by endarterectomy and homo

SUMMARY: Fall prevention is a key strategy for reducing osteoporotic fractures. We investigated the association between vitamin D receptor (VDR) polymorphisms and reported falls in postmenopausal women. Bsm1 polymorphisms were associated with falls, balance and muscle power measurements. These results may explain some of the excess fracture risk associated with VDR in some studies.INTRODUCTION: Fa

BACKGROUND: The importance of genetic factors in the etiology of Hodgkin lymphoma (HL) has been suggested by family and population studies. However, the spectrum of malignancies associated with common genetic etiology and the effects of gender and age on familial risk have not been established.METHODS: Diagnoses of lymphoproliferative malignancies were compared in 15,799 first-degree relatives of

Carcinoids are rare neuroendocrine tumors, mainly located in the bowel, stomach and lung. Familial risks in carcinoid tumours are not well known apart from multiple endocrine neoplasia 1 (MEN1). We used the nation-wide Swedish Family-Cancer Database on 10.1 million individuals for assessment. Carcinoid tumors were retrieved from the Cancer Registry covering the years 1958-1998. The offspring gener

Genetic studies of complex traits have become increasingly successful as progress is made in next-generation sequencing. We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. We used next-generation sequencing to identify si

Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown. We investigated the effects of asthma-associated SNPs on DNA methylation and mRNA levels of GSDMB and ORMDL3. Genetic association between GSDMB/ORMDL3 and physician

With the advent of increasingly advanced spectroscopic instruments after the turn of the century, it has become accessible to unravel the structure of instantly ‘vanishing’ nuclei, with lifetimes as short as 1 μs, and responsible for pile-up events in analog electronics. Experimental data has been recorded by the Nuclear Structure Group at Lund University for 48Ca/50Ti + nat.Hf reactions during th

Sub-band full duplex is a new communication scheme technology, where a single frequency band is partitioned into sub-bands for downlink (DL) and up-link(UL) transmissions, and both can take place simultaneously. The idea behind the sub-band full duplex development is to improve the throughput, and coverage and reduce the latency of the UL communication by allowing the UL reception during the DL tr

The aim of this thesis is to explore the relative importance of the eight psychological Active Innovation Resistance (AIR) barriers, from the new typology of AIR barriers developed from Talke and Heidenreich in 2014, on the consumer’s intention to adopt or buy circular fashion products. Moreover, this thesis examines whether the socio-demographic factors of age, employment status, and educational

STYRD KYLNING AV GJUTGODS – ett allt hetare ämne Många industrier står idag inför stora utmaningar angående resurseffektivitet och energi-användning, inte minst de som involverar väldigt energikrävande processer. Metall- och gjuteriindustrin står idag för ungefär 15% av energi-användningen i Sverige. Därför finns det intresse att utreda möjligheterna för att återanvända värme som i dagsläget går tIn this project, the cooling and solidification processes for a Valmet Foundry product have been simulated in order to shorten the cooling time. The study has also been done in cooperation with RISE Swecast in Jönköping, as a part of finding ways to make casting procedures more energy efficient. Another scope of the study is to evaluate how well COMSOL Multiphysics can be used to simulate these ty

The purpose of this study was to get a better understanding of sex as self-injury in the form of prostitution among young women. With a better understanding of this subject, hopefully, signs pointing at sex as self-injury can be identified earlier, which could lead to increased identification of women who live with these behaviors. Thus more preventive work can take place where professionals can c

I familjerätten är begreppet barnets bästa välkänt. Detta begrepp är avgörande när domstolar och sociala myndigheter ska ta beslut beträffande vårdnad, boende och umgänge. Vad som är barnets bästa avgörs i det enskilda fallet, men risken att barnet eller en annan familjemedlem far illa och barnets behov av en nära och god kontakt med dess föräldrar ska särskilt beaktas. Således är det genomgående In family law, the concept of the best interest of the child is well known. This concept is crucial when courts and social agencies are to take decisions regarding custody, resident and access. What the best interest of the child is gets determined in the individual case, but the risk that the child or another family member gets harmed and the child's need for close and good contact with its p

I februari 2016 lämnade Barnrättighetsutredningen förslag på hur barnkonventionen ska inkorporeras i svensk rätt. Uppsatsens syfte har varit att belysa detta förslag utifrån principen om barnets bästa, och dess frågeställning har varit om principen om barnets bästa skulle påverkas av en inkorporering, och i så fall hur. Fokus har legat på betydelsen av barnets bästa i 6 kap. föräldrabalken (FB) gäIn February 2016 The Inquiry on the rights of the child handed over a proposal for an act on incorporating the UN Convention on the Rights of the Child (CRC) into Swedish law. The purpose of this essay has been to illuminate this proposal in view of the principle of the best interests of the child, and the question at issue has been if the principle would get affected of incorporation, and in that

The Master Thesis, which is a part of the education to become Master of Science in Engineering, Industrial Engineering and Management, Faculty of Engineering, Lund University, has been written at Gambro in Lund. In 2006 new owners bought Gambro and Gambro has been working on new guidelines and strategies during the past year. The Master Thesis became a part of the work with new strategies and ther

The purpose with this master thesis was to identify which problems that were related to the implementation of AFS 2001:1, examine what they were caused by and to some extent come up with solutions to the problems. In order to do this a feasibility study, a literature study and five interviews with people working with AFS 2001:1 were done. The people who got interviewed work in one large and one li

The purpose of this study was to investigate how social workers, working with financial aid, creates participation for children and if their work has been affected by the legal enforcement of the Convention on the Rights of the Child and its children rights perspective. We used a qualitative method when interviewing in order to examine and find an answer to our purpose and question at issue. The r