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Caption: Most patients are in a coma the first days after a cardiac arrest. Clinical tests of brain stem function, neurophysiological methods (EEG and SSEP), imaging (CT and MRI) and measurements of biomarkers in the blood are used to assess the extent of brain injury.
Uppsatsen undersöker ämnet hållbara städer och tidigare forskning inom området indikerar att den sociala dimensionen av hållbarhet har varit mindre prioriterad än den ekonomiska och ekologiska dimensionen. På både svensk, nationell som internationell nivå har medborgardeltagande och delaktighet identifierats som centralt för den sociala dimensionen. Då deltagande och icke-diskriminering är centralInvestigating the matter of urban sustainability, previous research within the field argues that the social dimension of sustainability has been deprioritized, one potential reason being that it is less tangible then the economic and ecological dimension. Furthermore, citizen participation and inclusiveness is identified as central to the social dimension on an international as well as Swedish nat
The overall aim of the current research plan is to identify novel interventions to prevent neuro-developmental impairment in the newborn. From a clinical perspective, the project targets three groups of infants: 1) infants with extremely preterm birth (< 27 gestational weeks); 2) infants who develop severe cerebral intraventricular hemorrhage (IVH) and 3) infants with serious congenital heart defe
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) dat
This paper introduces a new class of algebras naturally containing, within a single framework, various deformations of the Witt, Virasoro and other Lie algebras based on twisted and deformed derivations, in addition to color Lie algebras and Lie superalgebras.
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate
Immune checkpoint inhibitors (ICIs) have received much attention not least for melanoma since the award of the Nobel prize in 2018. Here, we review the current state of knowledge about the use of these monoclonal antibodies (mAbs) in non-small cell lung cancer (NSCLC). These drugs have generally been conditionally approved on limited early data and there are few long-term follow-up data from rando
Ekonomisk-historiska institutionen har ett välgrundat rykte för sina omfattande forskningsprogram med tonvikt på långsiktiga processer, baserad på ekonomisk teori och med kvantitativa metoder som viktiga verktyg. Forskningsämnena är inriktade på frågor av hög relevans för samhället. Institutionens forskare genererar årligen en imponerande mängd internationell publicering och är mycket framgångsrThe Department of Economic History has a well-established reputation for wide-ranging research programmes with an emphasis on long-term processes, based on economic theory and quantitative methods as important tools. The research topics are oriented towards issues of high relevance for society. The Department has an acknowledged international publication record and is very successful at attracting
Forskargruppen Tillämpad Gerontologi bedriver tvärvetenskaplig forskning relaterad till äldre och åldrande med betoning på forskning som kan omsättas till handling och riktlinjer. Genom att arbeta över discipliner, mellan sektorer och i partnerskap med de personer som forskningen berör, vill vi utveckla och utvärdera strategier för att öka möjligheterna för människor att kunna delta i meningsfullThe Applied Gerontology Research Group conducts inter- and transdisciplinary research related to older age and ageing with an emphasis on research that can be translated to practice and policy. By working across disciplines, across sectors, and with citizens and other stakeholders, we aim to develop and evaluate strategies to enhance opportunities for people to engage in valued life activities des
För kroppens vävnader är omvandling av syrgas och näringsämnen till energi av stor vikt, och detta särskilt vid sjukdomsprocesser. Vi vill klargöra mitokondriens roll för organpåverkan, framför allt vid sjukdomar som drabbar det centrala nervsystemet men även vid organsvikt till följd av sepsis samt läkemedelsbiverkan. Forskningen är inriktad mot utveckling av nya strategier för diagnostik, behandThe energy-producing mitochondria are central to maintenance and survival of cells and have been proposed to participate in the pathogenesis of organ dysfunction. We use sensitive systems for analysis of mitochondrial function and have developed high-resolved respirometry applied to human blood cells. With this rapid and easy accessible method to monitor systemic mitochondrial function we determin
