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Lack of supportive evidence for the use of immunohistochemical staining to identify occult regional lymph node metastases in primary lung cancer.

Immunohistochemical (IHC) staining for the identification of nodal occult metastases (OM), not detected by routine histological examination, has been proposed for improved staging, prognostication and decision of adjuvant treatment in surgically treated primary lung cancer. In a prospective study, we analysed 178 cases of primary lung cancer stage I-III (N0-N1) for OM by immunostaining lymph node

Pulmonary 5-HT 2B receptor expression in fibrotic interstitial lung diseases.

Pulmonary fibrosis is a severe condition in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-ILD, where the underlying mechanism is not well defined and with no curative treatments available. Serotonin (5-HT) signaling via the 5-HT 2B receptor has been recognized as a promising preclinical target for fibrosis. Despite this, the involvement of the

TGF-β-mediated epithelial–mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma

Epithelial–mesenchymal transition (EMT) is a cellular process during which epithelial cells acquire mesenchymal phenotypes. Cancer cells undergo EMT to acquire malignant features and TGF-β is a key regulator of EMT. Here, we demonstrate for the first time that TGF-β could elicit EMT in a mouse lung adenocarcinoma cell line. TGF-β signaling activation led to cell morphological changes corresponding

Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer

Clinical trial results have recently demonstrated that inhibiting inflammation by targeting the interleukin-1β pathway can offer a significant reduction in lung cancer incidence and mortality, highlighting a pressing and unmet need to understand the benefits of inflammation-focused lung cancer therapies at the genetic level. While numerous genome-wide association studies (GWAS) have explored the g

Harmoniska förlopp i melodiska sololinjer i jazzimprovisation - - Analys av sju solon på jazzgitarr

Denna uppsats söker svar på frågan: Hur kan man få fram en tydlig harmonik och ett tydligt harmoniskt förlopp i melodiska sololinjer? Studien grundar sig på kvantitativa och kvalitativa analyser på transkriptioner av sju jazzsolon spelade av gitarristerna John Scofield, Pat Metheny, Kurt Rosenwinkel och Jesse Van Ruller. Uppsatsen omfattar en sammanfattning av jazzharmonilära, jazzteori och olika

The legally binding Charter and the EU’s accession to the ECHR - Consequences of Art 6 TEU for the autonomy of EU law and fundamental rights protection within Europe

I detta examensarbete analyseras och diskuteras de omfattande förändringar inom rättsområdet grundläggande rättigheter som följt efter att Lissabonfördraget trädde i kraft den 1 december 2009. Arbetet är avgränsat till att beskriva de förändringar som art. 6.1 och art. 6.2 i Fördraget om Europeiska Unionen (FEU) inneburit. Enligt art. 6.1 ska den Europeiska Unionens Stadga om de Grundläggande RättThis thesis analyses and discusses some of the substantial changes brought about for the field of fundamental rights by virtue of the entry into force of the Lisbon Treaty 1 December 2009; Art. 6(1) to the Treaty on European Union (TEU), according to which the Charter of Fundamental Rights of the European Union (CFREU) “shall have the same legal value as the Treaties” and Art. 6(2) TEU according t

Diabetes

This project aims to develop incretin therapy as a glucose-reducing strategy in type 2 diabetes (T2D). Its particular focus is to understand the mechanisms of incretin therapy and to optimize its clinical positioning. This mission is achieved by an interdisciplinary approach with complementary studies in subjects with T2D, healthy volunteers and experimental animals.

Professional and career development

Lund University's offer and KompetensportalenOn Lund University’s Staff Pages you can read about what courses you can register for in order to continue developing in your profession. on the Staff Pages you will also find a link to Kompetensportalen (Professional Development Portal)- Always speak to your immediate supervisor before making a booking.Professional development at Lund University (Lund

https://www.intramed.lu.se/en/employment/professional-and-career-development - 2026-05-27

Lund University Bioimaging Center

Our mission is to establish a major trans-faculty bio-imaging center at Lund University (Lund University Bioimaging Center), combining knowledge in the fields of medical physics, preclinical and clinical medicine, chemistry, technology and applied mathematics in order to develop imaging methods for the advanced study of human morphology, cellular metabolism and physiological function in health and

LU-ATMP: Lunds universitets centrum för avancerade terapier

Sweden's ATMP ecosystem is rapidly expanding, solidifying its place as a key player in Europe. Currently ranking among the top three countries among the EU9 for identified therapeutic ATMP companies, Sweden's strategic investments are further reinforcing its leadership (MSC 2020). This includes ongoing initiatives to establish industrial-scale ATMP manufacturing capabilities, enhancing the country

Pre-contrast T1 and cartilage thickness as confounding factors in dGEMRIC when evaluating human cartilage adaptation to physical activity

Background: The dGEMRIC (delayed Gadolinium-Enhanced MRI of Cartilage) technique has been used in numerous studies for quantitative in vivo evaluation of the relative glycosaminoglycan (GAG) content in cartilage. The purpose of this study was to determine the influence of pre-contrast T1 and cartilage thickness when assessing knee joint cartilage quality with dGEMRIC. Methods: Cartilage thickness