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Global warming is severely impacting ecosystems and threatening ecosystem services as well as human well-being. While some species face extinction risk, several studies suggest the possibility that fast evolution may allow species to adapt and survive in spite of environmental changes. We assess how such evolutionary rescue extends to multitrophic communities and whether evolution systematically p
Corruption is one of the most pressing and systemic issues of the 21st century,significantly hindering sustainable socio-economic development acrossnations. It undermines trust in authorities and legal institutions, which inturn diminishes investment activities, restricts entrepreneurial growth, andexacerbates social inequality. Kazakhstan, as a country actively working tomodernize public administ
An important tool for understanding the biology of muscle-invasive bladder cancer (MIBC) is molecular subtype classification. Molecular subtypes are qualitatively distinct biological entities that can be identified by molecular analysis of tumor tissue. This chapter describes how such entities have been discovered and described for MIBC and gives an overview of the characteristics that the luminal
Unpigmented skin cancer is the most prevalent form of cancer, and it burdens healthcare substantially even if it is not as aggressive as the more well-known malignant melanoma. Dermatoscopy images are commonly used for diagnosis, but differentiating between the many sub-diagnoses is a hard task. In this study we focus on these unpigmented cancers, performing both detection of basal cell carcinoma
BACKGROUND: Mean diffusivity (MD) and fractional anisotropy (FA) from diffusion MRI (dMRI) have been associated with cell density and tissue anisotropy across tumors, but it is unknown whether these associations persist at the microscopic level.PURPOSE: To quantify the degree to which cell density and anisotropy, as determined from histology, account for the intra-tumor variability of MD and FA in
Aquatic and terrestrial habitats are interdependent components of the boreal forest landscape involving multiple dynamic interactions; these are manifested particularly in riparian areas, which are key components in the forest landscape. However, this interdependence between aquatic and terrestrial habitats is not adequately accounted for in the current management of forest ecosystems. Here we rev
The theoretical part develops Michael Grossman’s dynamic demand-for-health model by (a) letting the depreciation rate depend upon the level of health, (b) allowing a continuous set of health states, (c) introducing uncertainty (by letting health be a stochastic variable), (d) introducing social and private insurance and (e) releasing the assumption of an isoperimetric budget constraint. Beside the
A dual-band CMOS front-end was designed and fabricated in a 0.18 μm CMOS process. The front-end employs a common-gate low noise amplifier (LNA) with capacitive cross coupling (CCC) technique and a passive mixer. The band selection is performed by switching a capacitor in and out of the LNA load, changing the resonance frequency between 2.2GHz and 4.0GHz. The measured noise figure is below 3.5dB fo
Popular Abstract in Swedish Vid mitten av 1800-talet öppnades speciella institutioner i Sverige med syftet att ”rädda” prostituerade kvinnor från ett ”förtappat liv” utanför samhällets ramar. Men vilka var de kvinnor som ville rädda, bli räddare? Var deras engagemang ett uttryck för omsorg eller kan det sociala arbetet ses som en klassrelaterad maktutövning, en vilja att kontrollera och disciplineThe object of this thesis is a Swedish religious reform movement that, from mid nineteenth century to early twentieth century, undertook social work intended to ‘rescue’ female prostitutes. The purpose of the study is to illuminate the encounter between two groups of women, the rescuers and the rescued. This encounter is principally seen from the rescuer’s perspective, since it is the rescue movem
This study deals with the problem of Austrian identity in the late Habsburg empire. The investigation departs from an understanding of this problem as situated in the juncture between the historical Austrian imperial experience and the process of modern Austrian identity formation. The Austrian identity is thus approached as the identity problem of the old German-Austrian center of the empire, as
Large amounts of methane (CH4) are known to be emitted from permafrost environments during the autumn freeze-in, but the specific soil conditions leading up to these bursts are unclear. Therefore, we used an ultrawide band ground-penetrating radar in Northeast Greenland in autumn 2009 to estimate the volumetric composition inside the soil through dielectric characterization from 200 to 3200 MHz. O
Abstract in Uncoded languages U ranijim istraživanjima ratnog nasilja, tokom rata u Bosni i Hercegovini, naglašavana je važnost priča ŽRTAVA ali fokus analize nije bio usmjeren na priče o ratnom nasilju, niti su analizirani poslijeratni intervjui kao produkt međuljudske interakcije. Ovom studijom pokušava se popuniti ta praznina analiziranjem priča osobe koje su preživjele rat u sjeverozapadnoj BoPrevious research on violence during the war in Bosnia and Herzegovina have emphasized the importance of narratives without focusing on narratives mentioning war violence, but they have not analyzed stories on war violence that were the product of interpersonal interaction and meaning-making activity. The aim of this study is to fill this knowledge gap by analyzing the narratives of survivors of t
Frequent regression testing is a core activity in agile software development, but large test suites can lead to long test running times, hampering agility. By safe RTS (Regression Test Selection) techniques, a subset of the tests can be identified that cover all tests that can change result since the last run. To pay off in practice, the RTS overhead must be low. Most existing RTS techniques are b
Background Diet and smoking are the main sources of cadmium exposure in the general population. Cadmium increases the risk of cardiovascular diseases, and experimental studies show that it induces inflammation. Blood cadmium levels are associated with macrophages in human atherosclerotic plaques. Soluble urokinase-type plasminogen activator receptor (suPAR) is an emerging biomarker for cardiovascu
The authors used the Swedish Family-Cancer Database to search for evidence for a genetic predisposition in lung cancer. Familial risks in offspring were increased for all lung cancer to 1.77 when a parent was affected with any lung cancers; the comparable risk among siblings was 2.15. At young age, risks between siblings were higher than those between offspring and parents for all histological typ
Diamond-Blackfan anemia (DBA) is a bone marrow failure syndrome caused by mutations in ribosomal protein genes. Pathogenic mechanisms are poorly understood but involve severely reduced proliferation of erythroid precursors. Because current DBA therapies are ineffective and associated with severe side effects, disease-specific therapies are urgently needed. We hypothesized that druggable molecular
