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This thesis aimed to increase the understanding of pump physiology in the remodeled heart compared to normal pump physiology.Study I was a cross-sectional observatory study investigating the regional contributions to stroke volume in patients with heart failure prior to cardiac resynchronization therapy (CRT) and tested the hypothesis that this characterization of pumping could predict CRT respons
Introduction There is controversy regarding the importance of air-transmitted infections for surgical site infections (SSIs) after orthopaedic surgery. Research has been hindered by both the inability in blinding the exposure, and by the need for recruiting large enough cohorts. The aim of this study is to investigate whether using a new form of air purifier using plasma air purification (PAP) in
OBJECTIVE: The aim of the current study is to understand why some individuals avoid developing Parkinson disease (PD) despite being at relatively high genetic risk, using the largest datasets of individual-level genetic data available.METHODS: We calculated polygenic risk score to identify controls and matched PD cases with the highest burden of genetic risk for PD in the discovery cohort (Interna
The dramatic improvements in Boolean satisfiability (SAT) solving since the turn of the millennium have made it possible to leverage state-of-the-art conflict-driven clause learning (CDCL) solvers for many combinatorial problems in academia and industry, and the use of proof logging has played a crucial role in increasing the confidence that the results these solvers produce are correct. However,
Mission-critical applications such as industrial control processes are evolving towards a new development paradigm by offloading their heavy computations to the edge of the emerging Fifth Generation Wireless Specifications (5G) network. In this manner, the applications can gain the economical and efficiency benefits of cloud computing, as well as reliable communication from the 5G network. However
Many problems in computer vision can be formulated as geometric estimation problems, i.e. given a collection of measurements (e.g. point correspondences) we wish to fit a model (e.g. an essential matrix) that agrees with our observations. This necessitates some measure of how much an observation 'agrees' with a given model. A natural choice is to consider the smallest perturbation that makes the o
The exponential increase in medical waste production has increased the difficulty of waste management, resulting in higher medical waste dispersion into the environment. By employing a circular economy approach, it is possible to develop new materials by waste valorization. The employment of biodegradable and renewable agro-food, waste-derived materials may reduce the environmental impact caused b
Currently, most research and public datasets for video sports analytics are base on detecting players as bounding boxes in broadcast videos. Going from there to precise locations on the pitch is however hard. Modern solutions are making dedicated static cameras covering the entire pitch more readily accessible, and they are now used more and more even in lower tiers. To promote research that can t
A hypothesis is presented suggesting that initiation of breast epithelial cell freezes the cell at least partly according to the development/differention of cell at the time of initiation. Tumour biology will mimic the physiology of normal cell development at the time of initiation and this is preserved at least partly onwards. Also preferentially, tumours will develop from the cell type that is p
A cohort of offspring of mothers with breast or ovarian cancer diagnosed in 1958-1993 was established using Swedish population-based registers. The children (n = 158,041) were born between 1941 and 1993, and their cancer incidence was followed between 1961 and 1993. A total of 3,257 tumors in 3,102 children were found. Observed numbers of cases were compared with expected numbers based on national
T-helper 1 polarization in patients with primary immune thrombocytopenia (ITP) is well documented. However, the genetic contribution to this imbalance remains unclear. To address this question, we selected six candidate single nucleotide polymorphisms within cytokine or cytokine receptor genes for association testing among Caucasian adults. Patients from the United Kingdom Adult ITP Registry were
Most products are developed while adapting to requirements from industrial production and logistics. To break that trend and design for people, we suggest focusing on those who put the strongest demands on the final solution. They cannot compensate for bad design solutions and are thereby, like sniffing dogs, guiding designers to meet peoples’ needs. We always use a combination of empathic modelli
Diamond–Blackfan anemia (DBA) results from haploinsufficiency of ribosomal protein subunits in hematopoietic progenitors in the earliest stages of committed erythropoiesis. Nemo-like kinase (NLK) is chronically hyperactivated in committed erythroid progenitors and precursors in multiple human and murine models of DBA. Inhibition of NLK activity and suppression of NLK expression both improve erythr
Background: Being overweight is becoming the new normal, and more than half of the adult Swedish population is overweight which poses a risk to public health. Overweight and obese women have both an increased risk and a worse prognosis for breast cancer, compared with women of normal weight. The breast cancer incidence in Sweden is increasing, and about one in nine women will be diagnosed with bre
Certifying solvers have long been standard for decision problems in Boolean satisfiability (SAT), allowing for proof logging and checking with very limited overhead, but developing similar tools for combinatorial optimization has remained a challenge. A recent promising approach covering a wide range of solving paradigms is pseudo-Boolean proof logging, but this has mostly consisted of proof-of-co
In this paper, we investigate ways to mitigate the problem of decoder error propagation (DEP) in sliding window decoding (SWD) of protograph-based spatially coupled low-density parity-check (SC-LDPC) codes for large frame length or streaming applications. In particular, in order to avoid subdividing a long frame into a series of shorter frames by using termination to combat DEP, we consider alteri
We introduce lower-bound certificates for classical planning tasks, which can be used to prove the unsolvability of a task or the optimality of a plan in a way that can be verified by an independent third party. We describe a general framework for generating lower-bound certificates based on pseudo-Boolean constraints, which is agnostic to the planning algorithm used. As a case study, we show how
In this paper, we present a new generic Structure-From-Motion pipeline, GenSfM, that uses a non-parametric camera projection model. The model is self-calibrated during the reconstruction process and can fit a wide variety of cameras, ranging from simple low-distortion pinhole cameras to more extreme optical systems such as fisheye or catadioptric cameras. The key component in our framework is an a
Background: Dihydrotestosterone (DHT), the most potent ligand to the androgen receptor, is synthesised from testosterone (T) by 5α-reductase type 1 and 2. While type 1 is expressed in several non-reproductive tissues in both sexes, men also express high levels of the high-affinity type 2 isoform in reproductive tissues; yet women have a higher circulating DHT to T (DHT/T) ratio than men. We hypoth
