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tRNA-derived stress-induced RNAs (tiRNAs) are a new class of small non-coding RNA that have emerged as important regulators of cellular stress responses. tiRNAs are derived from specific tRNA cleavage by the stress-induced ribonuclease angiogenin (ANG). Loss-of-function mutations in the ANG gene are linked to amyotrophic lateral sclerosis (ALS), and elevated levels of specific tiRNAs were recently
Introduction: Homecare services are limited, and there is likely a gap between the everyday activities homecare users want to do and the activities they perform or receive help with. Structured assessment on the desire for engaging in activities may be useful to identify unmet occupational needs.Aim: To reflect on the experiences of using the Occupational Gaps Questionnaire (OGQ) to investigate ho
Accelerated deterioration of the constituting materials is important for the long-term performance of bridges or any other load-bearing structure with several-decades-long service life. In addition to the economic consequences due to increased maintenance and repair needs, severe deterioration can lead to catastrophic collapses with possible injuries, life losses, and impairments to infrastructure
This thesis explores the relationship between AI, security, and social sustainability as a sociotechnical system, analyzing the implications and perspectives that arise from this understanding. It represents a culmination of four articles that rely on both conceptual insights and empirical findings. The articles incorporate diverse perspectives to enhance the comprehension of AI’s effects on socia
This article assesses what is analytically at stake when individuals claim that their rights under the European Convention on Human Rights have been interfered with and the respondent State invokes compliance with positive human rights obligations as the aim pursued with the interference. These situations could be framed as manifesting a tension between negative and positive obligations. This is a
Aim of the review: To provide an overview of studies that have published dataregarding region and population size, procedure location, team composition, inclusionand exclusion criteria, outcome parameters, and cost–benefit analyses onextracorporeal membrane oxygenation use for refractory out-of-hospital cardiac arrest.Data sources: A structured systematic literature search of articles published pr
In our Galaxy, light antinuclei composed of antiprotons and antineutrons can be produced through high-energy cosmic-ray collisions with the interstellar medium or could also originate from the annihilation of dark-matter particles that have not yet been discovered. On Earth, the only way to produce and study antinuclei with high precision is to create them at high-energy particle accelerators. Alt
The dynamic formation of chemical species composing the solid electrolyte interphase (SEI) layer at the surface of a carbonaceous electrode in a carbonate-based liquid electrolyte was observed in real-time using operando near-ambient pressure XPS (NAP-XPS). The potential of the glassy carbon electrode vs. metallic lithium was controlled during the XPS experiment. By following the binding energy sh
The question of the rationality of conspiratorial belief divides philosophers into mainly two camps. The particularists believe that each conspiracy theory ought to be examined on its own merits. The generalist, by contrast, argues that there is something inherently suspect about conspiracy theories that makes belief in them irrational. Recent empirical findings indicate that conspiratorial thinki
Considerable time is often spent optimizing antennas to meet specific design metrics. Rarely, however, are the resulting antenna designs compared to rigorous physical bounds on those metrics. Here, we study the performance of optimized planar meander line antennas with respect to such bounds. Results show that these simple structures meet the lower bound on the radiation quality factor (Q-factor)
In this paper list decoding of convolutional codes is considered. List decoding is a very powerful, low complexity, non-backtracking decoding method that does not fully exploit the error correcting capability of the code. A correct path loss is a serious kind of error event that is typical for list decoding. An expurgated upper bound on the probability of correct path loss is derived for the ensem
Abstract in UndeterminedThe secreted protein Dickkopf-1 (Dkk1) is an antagonist of canonical Wnt signaling, expressed during fracture healing. It is unclear how it is involved in the mechanical control of bone maintenance. We investigated the response to administration of a Dkk1 neutralizing antibody (Dkk1-ab) in metaphyseal bone under different loading conditions, with or without trauma. In this
Two submaximal cycle ergometer test methods, the Astrand nomogram test and a computerized two-point extrapolation test (Cat Eye ergociser, commercially available), were compared in order to determine agreement and repeatability of estimates of maximum oxygen consumption (VO2max). Twenty healthy women, divided into two groups of ten according to their age (mean 35.3 and mean 46.9), performed test-r
