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Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within <10 mg
Darknet framställs ofta som en digital värld präglad av avvikelse och kriminalitet – en plats där ”allt är tillåtet” och som därför anses kräva övervakning och kontroll. Trots detta är kryptoforum fortfarande relativt understuderade. Med utgångspunkt i tre års etnografiskt fältarbete ger denna avhandling nya insikter i de interna dynamikerna i en till stor del dold onlinegemenskap. Genom att kombiThe Darknet is often portrayed as an online realm marked by deviance and criminality – a space where “anything goes” and therefore requires policing. Yet its cryptoforums remain comparatively understudied. Drawing on three years of ethnographic fieldwork, this dissertation provides new insights into the internal dynamics of a largely hidden online community. Combining digital observations with 19
Breaking promises might be easier if one faces unexpectedly high costs for keeping them. Inspired by the ‘pledge and review’ mechanisms of the Paris Agreement, we investigate the role of cost uncertainty for both initial non-binding pledges and the subsequent voluntary provision of public goods. Without a pledge review process, we find that cost uncertainty not only leads to rather conservative pl
Organ trafficking is an illegal means of meeting the shortage of transplant organs on a global market. Reasons that this activity flourishes include medical needs, poverty and criminality. This article is focused on those who sell their organs. The ambition is to see how their actions are the result of a socio-cultural context as well as how ideas and actions impact the trafficking phenomenon. The
The enzyme ferrochelatase (EC 4.99.1.1) is the terminal enzyme in the biosynthetic pathway of heme b and catalyzes the insertion of Fe(II) into protoporphyrin IX. In this dissertation ferrochelatase from Bacillus subtilis was studied. A new purification method via inclusion bodies was developed that enabled simple purification of recombinant enzyme without tags or modifications that might affect t
This paper deals with path-based linear programming formulations in survivable network design. In a recent survey we have investigated the complexity of the column generation problems for a large variety of protection and restoration mechanisms in a single or multiple link failure scenario, and classified them according to their structure. It turned out that all the considered column generation pr
