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STUDY DESIGN: Cross-sectional study. BACKGROUND: Visual rating of postural orientation during functional tasks may be a valuable tool to track rehabilitation progress following anterior cruciate ligament (ACL) injury. A valid test battery assessing postural orientation as a separate construct is lacking. OBJECTIVES: To evaluate measurement properties of a test battery to assess postural orientatio
Objectives To compare risky sexual behaviours between HIV-positive persons initiated on antiretroviral therapy (ART) (ART-experienced) and persons waiting to start on ART (ART-naive) and assess predictors of risky sexual behaviours among HIV-infected patients in rural Rakai district, Uganda. Study design This is a cross-sectional study that used data from the Rakai Community Cohort Study (RCCS) da
Thyroid hormone level has been positively associatedwith breast cancer cell proliferation andtumour growth in experimental studies. However,previous observational studies have been contradictoryon the relationship between thyroidfunction and breast cancer. Age is a known riskfactor for breast cancer but its role as a prognosticfactor is less clear. The present thesis thereforeaimed to examine the
This paper examines demand for and access to private-sector extension services by contracted cotton producers in northern Tanzania. Data from a non-random survey of 520 smallholders show that only 21.9% received any extension and only 4.6% received extension from the cotton ginnery. Wealthier households were three times more likely to receive extension from any provider. While the public sector re
Human carbonic anhydrases (hCAs) play various roles in cells, and have been drug targets for decades. Sequence similarities of hCA isoforms necessitate designing specific inhibitors, which requires detailed structural information for hCA-inhibitor complexes. We present room temperature neutron structures of hCA II in complex with three clinical drugs that provide in-depth analysis of drug binding,
Despite of multitude investigations no reliable prognostic immunohistochemical biomark-ers in GIST have been established so far with added value to predict the recurrence risk of high risk GIST besides mitotic count, primary location and size. In this study, we analyzed the prognostic relevance of eight cell cycle and apoptosis modulators and of TP53 mutations for prognosis in GIST with high risk
Background: Recently, the development of Parkinson's disease (PD) has been linked to a number of genetic risk factors, of which the most common is glucocerebrosidase (GBA) mutations. Methods: We investigated PD and Gaucher Disease (GD) patient derived skin fibroblasts using biochemistry assays. Results: PD patient derived skin fibroblasts have normal glucocerebrosidase (GCase) activity, whilst pat
Background: There is very little research on the parent's experiences of having a child admitted to a paediatric intensive care unit. Identifying and describing ‘such experiences’ could facilitate better parental support from the paediatric intensive care team and help the parents manage a stressful situation. Aims: This study aimed to describe parents' experiences of having their child admitted t
We describe a class of three Higgs doublet models (3HDMs) with a softly broken U(1) × U(1) family symmetry that enforces a Cabibbo-like quark mixing while forbidding tree-level flavour changing neutral currents. The hierarchy in the observed quark masses is partly explained by a softer hierarchy in the vacuum expectation values of the three Higgs doublets. As a consequence, the physical scalar spe
Background: Father's health is important for mothers and unborn/newborn children and knowledge about expectant fathers’ health in relation to lifestyle and psychosocial aspects is essential. Aims: To determine sociodemographic and lifestyle factors, self-reported health and sense of coherence among fathers and partners in relation to their risk for depression and anxiety in early pregnancy. Method
Heteroleptic iron based complexes bearing the 2,6-bis[3-(2,6-diisopropylphenyl)imidazol-2-ylidene]pyridine motif and a polypridine ligand have been synthesized and characterized in their ground and excited state. This series of complexes includes a first example of a hetero-bimetallic complex connecting an iron N-heterocyclic carbene photosensitizer with a cobalt dimethylglyoxime fragment. Focus i
The established effect of turmeric and its curcuminoids on appetite sensations was previously shown to be mediated by gut hormones release. In in vitro and preclinical studies, curcumin was shown to induce GLP-1 secretion and improve postprandial glycemia. In humans, consumption of 220 mL turmeric-based beverage (TUR, containing 185 mg gallic acid equivalents (GAE)) prior to white wheat bread (WWB
Nitrate pollution of groundwater has increased dramatically worldwide due to increase of population and agricultural productivity. The resulting nitrate concentration in groundwater is usually a combination of various types of point and non-point pollutant sources. It is often difficult to distinguish between these sources since groundwater is formed in large and complex catchments with various na
In the early era of transplantation, it was common practice to exclude diabetic patients since the outcome in such cases was usually poor. At our center in Malmö, Sweden, diabetic nephropathy was never regarded as a contraindication. During the 22-year period from 1972 to 1993, 223 renal allografts were transplanted in 189 uremic diabetics, representing 24% of all renal transplant recipients (n =
Importance: Neonatal hyperbilirubinemia can cause lifelong neurodevelopmental impairment (kernicterus) even in high-resource settings. A better understanding of the incidence and processes leading to kernicterus may help in the design of preventive measures.Objectives: To determine incidence rates of hazardous hyperbilirubinemia and kernicterus among near-term to term newborns and to evaluate heal
Background: The aim was to evaluate what can be learned from rat models when treating patients suffering from a sciatic nerve injury.Methods: Two patients with traumatic sciatic nerve injury are presented with examination of motor and sensory function with a five-year follow-up. Reconstruction of the nerve injury was performed on the second and third day, respectively, after injury using sural ner
Root channel serve as one major type of pathway for water flow in forest soil. In this paper, we combined a dye tracer experiment and a monolith method to distinguish the fine roots (0 < d ≤ 5 mm) that served as preferential water flow pathways in rocky mountainous areas. The characteristics of these types of roots among different soil layer and different root diameter were discussed. In this modi
