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This article argues that George Eliot's The Mill on the Floss (1860) aligns natural catastrophe with the image of the disastrous female body in order to challenge contemporary geological readings of nature as a balanced, self-regulating domain. Both incorporating and revising the work of Charles Lyell, Oliver Goldsmith, and Georges Cuvier, Eliot emphasises the interconnectedness of human and plane
Most natural antisense RNAs display a high degree ofsecondary structure with stem-loops as their mostprominent feature. Mutations affecting the Inhibitoryactivity of these RNAs most often map in or close toloop regions in both the antisense and target RNAs.The primary recognition loops often contain 5- 7unpaired nucleotldes. Nucleotide changes in the loopsaffect the binding rate and, hence, the in
We investigate how experiencing parental death in infancy, childhood, or adolescence affected individuals' health using two distinct measures: mortality before age 20 and young adult height. Using two complementary indicators of health enables us to gain more insights into processes of selection and the scarring of health. Employing nationally representative data for the Netherlands for the 1850-1
Biogeochemical cycling of silicon (Si) in the Barents Sea is under considerable pressure from physical and chemical changes, including dramatic warming and sea ice retreat, together with a decline in dissolved silicic acid (DSi) concentrations of Atlantic inflow waters since 1990. Associated changes in the community composition of phytoplankton blooms will alter the material comprising the deposit
Blue cone monochromacy (BCM) is an X-linked retinal disorder characterized by low vision, photoaversion, and poor color discrimination. BCM is due to the lack of long-wavelength-sensitive and middle-wavelength-sensitive cone photoreceptor function and caused by mutations in the OPN1LW/OPN1MW gene cluster on Xq28. Here, we investigated the prevalence and the landscape of submicroscopic structural v
Glial cell line-derived neurotrophic factor (GDNF) has been shown to counteract seizures when overexpressed or delivered into the brain in various animal models of epileptogenesis or chronic epilepsy. The mechanisms underlying this effect have not been investigated. We here demonstrate for the first time that GDNF enhances GABAergic inhibitory drive onto mouse pyramidal neurons by modulating posts
In 2020, almost all research labs in industry, academia, and the government were shut down for long periods of time by political leaders to control the spread of the coronavirus. We consider the “micro” and “macro” implications of ongoing coronavirus disruptions in scientific research and the dissemination and commercialization of that research. We have identified three key unanswered research que
Allozyme data were used to assess the genetic structure between 37 sympatric populations of the species-pair Silene vulgaris and S. uniflora ssp. petraea, and to infer levels of intra- and interspecific gene flow in the two species. Silene vulgaris is a geographically widespread weed of disturbed habitats whereas S. uniflora ssp. petraea is endemic to the Baltic islands of Öland and Gotland. On Öl
By changing the institutionalised practices associated with resource distribution, the sharing economy could support sustainable urban transformations. However, its impacts on urban sus-tainability are unknown and contested, and key actors hold different perceptions about them. Understanding how they frame these impacts could help solve conflicts and outline what can be done to influence the devel
In the last 15 years or so, soft selective sweep mechanisms have been catapulted from a curiosity of little evolutionary importance to a ubiquitous mechanism claimed to explain most adaptive evolution and, in some cases, most evolution. This transformation was aided by a series of articles by Daniel Schrider and Andrew Kern. Within this series, a paper entitled “Soft sweeps are the dominant mode o
While the glucose transporter-4 (GLUT4) is fundamental to insulin-regulated glucose metabolism, its dynamic spatial organization in the plasma membrane (PM) is unclear. Here, using multicolor TIRF microscopy in transfected adipose cells, we demonstrate that insulin regulates not only the exocytosis of GLUT4 storage vesicles but also PM distribution of GLUT4 itself. In the basal state, domains (clu
This article studies the import of East German films by Swedish public service broadcaster Sveriges Radio, and their reception in the Swedish public sphere. While few GDR films reached theatrical distribution, Swedish television imported and broadcasted over 30 productions by the state-owned film studio DEFA during the 1970s and 1980s, making this the primary distribution window for East German fi
The Royal flagship Gribshunden carried the Danish King Hans on its way to the city of Kalmar in Sweden when the ship sank in the summer of 1495. The ship caught fire while anchored north of the Stora Ek o Island and sank to the seafloor, where it lies to this day. The wreck was rediscovered in the 1970s and is remarkably well preserved.Since 2001, scientific investigations have been performed on t
The influence of the Sc cation substituent on the structural and luminescence properties of GAGG:Ce crystals was studied. Unit cell parameters and space groups were obtained using XRD analysis. The chemical compositions of the crystals were determined using SEM-EDX and TEM-EDX techniques. Structures were refined by the Rietveld method and the distribution of Al/Ga/Sc cations between octahedral and
The cost-effectiveness of smoking cessation interventions is well documented. However, most studies are based on randomized controlled trials (RCTs) and provide little information on the differences between subgroups. This study assessed the relative cost-effectiveness of smoking cessation interventions offered to various subgroups of smokers, based on real-life data. Regression analyses provided
We review recent progress made in understanding the role of medium polarization on superuidity in finite nuclei and in the inner crust of neutron stars. The interweaving of collective and quasiparticle degrees of freedom is treated within the framework of Nuclear Field Theory, propagating the basic renormalization processes through the Nambu-Gor’kov equations. It is then possible to obtain quantit
Many cities are striving to develop urban transformation strategies, in order to transit from traditional city to a sustainable city. Improving the energy efficiency of the existing buildings is the key to address climate change mitigation and adaptation. This paper considers different climate scenarios using different series of future climate in four different European cities, namely, Kiruna, Sto
In this volume, the authors reflect on the question “what is socialism” as it pertains to today’s economy. There is particular emphasis on democratic socialism models as a potential alternative to classic authoritarian socialism. A number of topical questions are addressed such as: What is democratic socialism and is it feasible, or even viable? What can be learnt from existing democratic socialis
We examine the impact of innovation disclosure through patenting on firms' cost of debt, focusing on the American Inventors Protection Act (AIPA) as an exogenous shock in innovation disclosure regulation. Post-AIPA, firms have an incentive to apply for patents only if commercial success is likely. Accordingly, we expect post-AIPA patents to be a better proxy for successful innovation activity, and
