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Activation of the sigma-1 receptor (Sig-1R) improves functional recovery in models of experimental stroke and is known to modulate microglia function. The present study was conducted to investigate if Sig-1R activation after experimental stroke affects mediators of the inflammatory response in the ischemic hemisphere. Male Wistar rats were subjected to transient occlusion of the middle cerebral ar
In today's competitive society the difference between winning and disappearing might very well be dependent on who is first to release a new product or an update to an existing product to the market. The impact that this situation has on the design analysis department in a company is tremendous. It is a known fact, to everyone working with design analysis, that the demands on analyses from the pro
Utilities, such as steam or cooling water, have shown to play an important role within the process industry, since a malfunctioning utility is a plant-wide disturbance that can lead to large revenue losses due to reduced production quantities. This work focuses on identifying disturbances on utilities that give economical consequences. Measures of utility availability and area availability are int
We analyse the effects of soil type on mortality of children aged 2-15 living in five rural parishes in Sweden between 1850 and 1914. We use micro-level longitudinal demographic data combined with micro-level longitudinal geographic data. Here, the individuals in the parishes are linked to the property units they lived in. We find that, compared to those living in property units covered by 80-100%
Popular Abstract in Swedish Fetma, övervikt och allergi är ett problem i många delar av världen och förändringar i tarmens bakterieflora kan vara en av flera orsaker. Människan har tio gånger fler mikroorganismer än mänskliga celler. Flest mikroorganismer finns i tarmen och de brukar gemensamt kallas för tarmfloran. Många bakterier är helt oskadliga och en del är dessutom nödvändiga för att vi tilThe gastrointestinal tract of the foetus is considered sterile but during vaginal birth the neonate comes into contact with bacteria from the maternal vaginal and intestinal microbiota. The main focus of this doctoral thesis was to elucidate the initial bacterial ecosystem in newborns and to relate microbial perturbations to physiological traits. The bacterial flora was mainly studied with molecu
Background: Despite the fact that old people´s technological needs have been payed much attention to in the last decennium, especially old users of information- and communication technology, technology has not found its natural place in research on ageing in modern societies. Purpose: This article examines to what extent social science research exist in the field of ageing and technology and where
Over the past few years, wireless mesh networks are emerging as a strong technology for cheap wireless coverage. Despite recent advances in wireless mesh networking, many research challenges remain in all protocol layers. Since a mesh network usually has very different characteristics than those of current fixed mobile networks, traditional fixed deployments such as those in cellular IP and HMIP w
User-related effects of a Driver Assistance System for Continuous Support on driver behaviour, were evaluated in a field test carried out in 2013. Twenty four drivers took part in test drives with a within-subject design along a 53 km test route containing motorway and rural-road sections. Driving data was logged and the test drivers were observed by means of an in-car observation method (Wiener F
Excessive production of collagen is the hallmark of fatal diseases of fibrosis such as systemic sclerosis. Overexpression of the proteoglycan fibromodulin (FMOD) has been associated with improved wound healing and scarless repair. In this study we have investigated the consequences of FMOD deficiency on the development of experimental skin fibrosis. Using immunohistochemistry, we identified FMOD i
