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The primary aim of this study is to assess the significance of top management commitment in the context of Lean 4.0 implementation within the pharmaceutical manufacturing industry in Ghana. The study seeks to understand and evaluate the overall effectiveness and achievements associated with adopting Lean 4.0. Employing a positivist mindset, the research utilizes an explanatory quantitative researc
Therapeutic resistance and recurrence remain core challenges in cancer therapy. How therapy resistance arises is currently not fully understood with tumors surviving via multiple alternative routes. Here, we demonstrate that a subset of cancer cells survives therapeutic stress by entering a transient state characterized by whole-genome doubling. At the onset of the polyploidization program, we ide
Postural orthostatic tachycardia syndrome (POTS) occurs in approximately 30% of people with highly symptomatic post-COVID-19 condition (PCC). It involves several symptoms that limit physical and psychological functions and cause reduced quality of life. Evidence for different treatments of POTS and PCC is limited, and this study aimed to evaluate the feasibility of individually tailored physical e
This study adopts a configurational approach to discover conditions common to graduates from venture creation programs who take a particular learning pathway to high entrepreneurial passion. Our theoretical framework identifies two primary sources of experiential learning (direct and vicarious experience) and three temporal vantage points (pre-, peri-, and post-education) conducive to such conditi
Dynamic restructuring of silver catalysts during the industrial conversion of methanol to formaldehyde leads to surface faceting and pinhole formation. Subsequent sintering under reaction conditions, followed by increased pressure drop and decreased catalyst activity requires catalyst bed replacement after several months of operation. This necessitates a comprehensive understanding of the bulk cat
BACKGROUND: Recent studies have reported that reduced-dose trimethoprim-sulfamethoxazole (TMP-SMX) may be effective in the treatment of Pneumocystis jirovecii pneumonia (PJP), but data are lacking for patients with hematologic malignancies.METHODS: This retrospective study included all adult hematologic patients with PJP between 2013 and 2017 at 6 Swedish university hospitals. Treatment with 7.5-1
Objectives: Minimally invasive cardiac surgery techniques are increasingly used but have longer cardiopulmonary bypass time, which may increase inflammatory response and negatively affect coagulation. Our aim was to compare biomarkers of inflammation and coagulation as well as transfusion rates after minimally invasive mitral valve repair and mitral valve surgery using conventional sternotomy. Des
Artikeln utforskar den snabba och COVID-19 pandemiframkallade migrationen från campus till digital undervisning 2020–2021. Migrationsprocessen erbjuder en möjlighet att undersöka flera viktiga frågor relaterade till digital undervisning, lärande och utbildning. Baserat på vår studie av situationen för School of Social Work vid Tata Institute of Social Sciences i Mumbai, Indien, och Socialhögskola
Numerical simulation tools and experimental measurement techniques are required to provide accurate description of flow features in application relevant scales and boundary conditions enroute to realizing the design and integration of high-speed arial platforms. A case of 10° wedge exposed to Mach 3.5 supersonic flow at high Reynolds numbers provides an opportunity to conduct a comparative analysi
The European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) organized its bi-annual forum EUFOREUM in Berlin in November 2023. The aim of EUFOREUM 2023 was to highlight pediatric action plans for prevention and optimizing care for type 2 inflammatory conditions starting in childhood, with a focus on early-stage diagnosis, ensuring neither under- nor overdiagnosis, optim
Uncertainty in our calculations of a system reveals the limits of our knowledge. This limitation makes model representations of the Earth system challenging and our predictions less reliable. However, despite appearing chaotic and non-linear, a system always follows a deterministic trajectory, which can often be expressed probabilistically. Building on this concept, this thesis applies data assimi
Aim: There is ongoing controversy regarding the extent to which Hartmann's procedure (HP) should be used in rectal cancer treatment. This study was designed to investigate 30-day postoperative morbidity and mortality following HP, anterior resection (AR) and abdominoperineal resection (APR) for rectal cancer using a national registry. Methods: All patients operated for rectal cancer, tumour height
Description: It is stated that even though plentiful of studies over the last decades have been concerned with internationalization in/of higher education, it has not been from the perspectives from the teachers and students and their experiences of aspects of internationalization in relation to their educational context (that is, as a student, and as a teacher). To emphasize the quality dimension
The purpose of this work is the enhancement of performance by a new design of monolithic heat exchangers under steady-state operating conditions. Heat transfer phenomena and hydrodynamics have been studied and visualized by computational fluid dynamics (CFD). Further, a simple gas distribution system has been analyzed in purpose to find best performance of the exchanger. To achieve this, 3D simula
This chapter explores the links between climate change, environmental degradation, and protracted armed conflicts, focusing on how international law can facilitate effective environmental interventions. It examines how international law, particularly the work of the UN International Law Commission on the Protection of the Environment in relation to Armed Conflicts (PERAC) Principles, international
