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Introduction: Monitoring replacement therapy with standard and extended half-life (EHL) products is challenging, since one-stage assay (OSA) and chromogenic substrate assay (CSA) results may differ significantly. Recent recommendations include local validation of each new product with recovery within 20–30%, depending on activity level. Aim: To validate factor VIII (FVIII) activity for monitoring
Exercise can improve health among adolescents with depression. Understanding facilitators for and barriers to maintaining exercise among adolescents with depression may increase adherence to exercise and consequently improve health. The aim was to explore adolescents’ experiences of facilitators for and barriers to maintaining exercise after a group-based exercise intervention for depression. Inte
Purpose: The aim of this planned study is to evaluate the ability of a cranial microwave scanner in conjunction with nine brain biomarkers (Aβ40, Aβ42, GFAP, H-FABP, S100B, NF-L, NSE, UCH-L1 and IL-10) to detect and rule out traumatic intracranial hemorrhage in an emergency department setting. Traumatic brain injury is a world-wide topic of interest for researchers and clinicians. It affects 2% of
Background The number and rank order of siblings could be of importance for risk of cardiovascular disease and mortality. Previous studies have used only fatal events for risk prediction. We, therefore, aimed to use also non-fatal coronary and cardiovascular events in fully adjusted models. Methods From the Multiple-Generation Register in Sweden, data were used from 1.36 million men and 1.32 milli
Background: RORγt is a transcription factor that enables elaboration of Th17-associated cytokines (including IL-17 and IL-22) and is proposed as a pharmacological target for severe asthma. Methods: IL-17 immunohistochemistry was performed in severe asthma bronchial biopsies (specificity confirmed with in situ hybridization). Primary human small airway epithelial cells in air liquid interface and p
Objective: Previous studies have shown that both sleep duration and insomnia have an impact on obesity and central obesity. However, studies of the joint effects of these sleep disorders are still sparse. Methods: The present study utilized data from the Swedish EpiHealth cohort study. Participants (45–78 y) were asked to fill out an internet-based questionnaire. Body mass index (BMI) and central
Environmental stresses, including ammonium (NH4 +) nourishment, can damage key mitochondrial components through the production of surplus reactive oxygen species (ROS) in the mitochondrial electron transport chain. However, alternative electron pathways are significant for efficient reductant dissipation in mitochondria during ammonium nutrition. The aim of this study was to define the role of ext
The anticoagulant warfarin is commonly monitored with prothrombin time (PT). Viscoelastic haemostatic assays (VHA) are primarily used in situations of acute bleeding to guide haemostatic therapy. Much research has focused on VHA monitoring of new oral anticoagulants. However, many patients are still anticoagulated with warfarin and effect of warfarin anticoagulation on VHA is uncertain. The aim of
Technological advances, with increasing numbers of products containing complex electronic circuitry, have resulted in e-waste becoming the fastest-growing global waste stream. High levels of embodied carbon in these products ensure that, to meet emissions reduction targets proposed by the United Nations Paris Agreement, tackling e-waste requires strategies to address climate change United Nations
Studies on the natural human exposures to fine particulate matter (PM2.5) and their elements composition are practically non-existent in South America. In order to understand the natural exposure of the typical Brazilian population to PM2.5 and their trace element composition, we measured PM2.5 concentrations and collected mass on filters for nine continuous hours during a typical workday of volun
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted
Abnormal trophoblast cell apoptosis is implicated in the pathogenesis of pregnancy-related disorders including preeclampsia (PE), and endoplasmic reticulum (ER) stress has been considered as a novel pathway in the regulation of cell apoptosis. In this study, we observed that both apoptosis and ER stress are triggered in trophoblast cells under hypoxia as well as in the placenta of PE rats. Quantit
Purpose: To model prediction of undetected glaucoma in a predominantly white population, based on intraocular pressure (IOP) and subject age. Methods: In 1992–1997, a population screening for glaucoma was performed at Malmö University Hospital where individuals between 55–79 years of age (n = 46 614) living in Malmö, were invited to a free eye health examination. Recently examined patients were no
The growth of biomass-based markets for transport fuel is an expanding geographical process driven by regulation in the European Union (EU). Based on a certification scheme that illustrates the regulatory mechanisms in the EU’s liquid biofuel market, this article explains how larger processes of territorialisation and uneven development interact with specific processes of commodity production and
The international development community is transitioning from the era of the Millennium Development Goals (MDGs), ending in 2015, to the era of the Sustainable Development Goals (SDGs), which have a 2030 target. Global development assistance for health (DAH) increased substantially in the MDGs era, from US $10.8 billion in 2001 to $28.1 billion by 2012 (in 2010 US dollars), and it played a crucial
People with repeated rapid meal ingestion have been reported to have increased risk of insulin resistance, impaired glucose tolerance and obesity. To explore whether speed of eating a breakfast influences the postprandial rise of glucose, insulin and the incretin hormones, 24 healthy subjects (12 men and 12 women, mean age 62 years) ingested a standardized solid breakfast consisting of 524 kcal (6
Bikunin and alpha1-microglobulin are two plasma proteins of about 25 kDa which are made in the liver from a common precursor. The concentration of bikunin in human urine has been shown to increase several fold during various conditions of stress. The mechanism behind this increase is unknown. We have studied pregnant rats and found that the bikunin and alpha1-microglobulin levels in their urine in
