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We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced caspase-3 activation in the rat ventral mesencephalon, which was mostly associated with glial cells. In contrast, nigral DA neurons exhibited AIF nuclear translocation in response to LPS. A significant decrease of the Bcl-2/Bax ratio in nigral tissue after LPS injection was obse
Over 14 000 patients aged 15-24 are estimated to be diagnosed with cancer in the European Union (EU) each year. Teenagers and young adults (TYA) often fall down gaps between children's and adults cancer services. The specific challenges of providing optimal care to them are described, but we present a summary of recent progress. Progress to overcome these challenges is happening at different rates
OBJECTIVE: Diamond-Blackfan anemia (DBA) is a rare congenital hypoplastic anemia caused by mutations in ribosomal protein (RP) genes. Our aim is to develop gene therapy for DBA patients with mutations in RPS19. We previously demonstrated that RPS19 gene transfer partially corrects erythroid development in vitro. In this study, we asked if RPS19 gene transfer corrects erythroid development in unsor
BACKGROUND: -Atrial fibrillatory rate (AFR) is a measure of atrial remodeling caused by atrial fibrillation (AF) and its acceleration negatively affects outcome of interventions for persistent AF. However, the prognostic value of AFR in patients with CHF has not been studied. We sought to evaluate whether AFR can predict outcome in patients with mild to moderate (NYHA II-III) congestive heart fail
Non-invasive tests for the detection of peripheral artery disease (PAD) among individuals with diabetes mellitus (DM) are important to estimate the risk of amputation, ulceration, wound healing and presence of cardiovascular disease, yet there are no consensus recommendations to support a particular diagnostic modality over another. To evaluate the performance of index non-invasive diagnostic test
We evaluated whether matrix metalloproteinases (MMPs) 2 and 9, their inhibitors, markers for fibrinolysis, and thrombin activation are associated with diameter and growth of abdominal aortic aneurysms (AAAs). Material and Methods: Matrix metalloproteinases 2 and 9, tissue inhibitor of MMPs (TIMP-1), serpine-1, tPa-serpine-1, and activated protein C- protein C inhibitor (APC-PCI) complex were analy
Annual and seasonal variations in surface air temperature (SAT) during the period 1961–2011 were analysed using daily mean temperature data sets from regular grid points (10?×?10?km2) throughout Finland. The Mann–Kendall nonparametric test was used to detect significant historical trends in SAT and Spearman's correlation coefficient (?) to test the relationships between SAT patterns and various at
OBJECTIVE: The visual system is vital during critical activities such as driving. Studying how alcohol compromises the visual system physiologically is therefore important for safety reasons. The objective of the study was to investigate alcohol-related impairments in visual tasks performed under controlled breath alcohol concentrations (BAC) to determine dose-dependent effects. METHODS: Alcohol's
We present a comprehensive and clinically applicable fMRI test-including both a verbal and a visuospatial task-for assessment of hemispheric specific memory in the medial temporal lobe (MTL). fMRI data was collected from 15 healthy right-handed volunteers. Whole-brain activation was analyzed as well as activation in two regions of interest: the MTL and the anterior speech area. Laterality indices
We report the structure of a novel tetrameric form of the lactose repressor (LacI) protein from Escherichia coli refined to 2.1 A resolution. The tetramer is bound to 1.6-hexanediol present in the crystallization solution and the final R(free) for the structure is 0.201. The structure confirms previously reported structures on the monomer level. However, the tetramer is much more densely packed. T
Previous studies on lymphocytes have suggested that patients with head and neck squamous cell carcinoma (HNSCC) have an increased susceptibility for chromosomal damage induced by bleomycin, a known radiomimetic mutagen. However, it has so far not been possible to study whether this genetic instability is present also in the epithelial component of the upper aerodigestive tract mucosa, the tissue f
A novel application of cellobiose dehydrogenase (CDH) as sensing element for a Bioelectronic Tongue (BioET) system has been tested. In this work CDHs from various fungi, which exhibit different substrate specificities, were used to discriminate between lactose and glucose in presence of the interfering matrix compound Ca(2+) in various mixtures. This work exploits the advantage of an electronic to
Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos kvinnor världen över och den står för omkring 30% av all cancer hos kvinnor i Sverige. Varje år får ca 7000 kvinnor i Sverige diagnosen och man räknar att ca en av tio kvinnor insjuknar under sin livstid. Trots att så många får bröstcancer så är det betydligt färre kvinnor som dör av bröstcancer; för närvarande ca 1500 per The aim of this thesis was to study reproductive factors and genetic polymorphisms in relation to breast cancer risk and survival. An important component of this was to investigate the risk of specific breast cancer subgroups. The association between parity and breast cancer-specific survival was studied among 4,453 women diagnosed with breast cancer in Malmö, Sweden. It was found that: • Nullipar
50 years ago, on June 11, 1963 president John F Kennedy, in live television, gave his commemorated speech to the American people where he declared his demand for civil rights for all Americans. The film Guess who is coming to dinner (Stanley Kramer, 1967) was an attempt to raise this question again by bringing up the topic of interracial marriage. This essay aims at studying how this is done, by s
The pathophysiology of myocardial infarction (MI) may differ depending on whether it occurs early or late in life. We tested the hypothesis that risk factor pattern differs according to the age at MI.
