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The (dynamic) frame model, originating in artificial intelligence and cognitive psychology, has recently been applied to change-phenomena traditionally studied within history and philosophy of science. Its application purpose is to account for episodes of conceptual dynamics in the empirical sciences (allegedly) suggestive of incommensurability as evidenced by “ruptures” in the symbolic forms of h
Studies of institutional transformation in science have largely overlooked Big Science installations, despite far-reaching changes to the roles and functions of such large labs in the past decades. Here, we present and analyze two Big Science labs that have undergone profound transformations from single-purpose particle physics labs to multi-purpose centers for so-called photon science: SLAC in th
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A comparison is made between the development trends experience over the last decades by the steel and papermaking industries, respectively. These two industrial branches, although totally different in their technical nature, are subject to similar pressures from their external environment, notably increasing requirements for environmental protection and more efficient raw material management. Such
Whole-lake additions of dissolved inorganic C-13 were used to measure allochthony (the terrestrial contribution of organic carbon to aquatic consumers) in two unproductive lakes (Paul and Peter Lakes in 2001), a nutrient-enriched lake (Peter Lake in 2002), and a dystrophic lake (Tuesday Lake in 2002). Three kinds of dynamic models were used to estimate allochthony: a process-rich, dual-isotope flo
We complete here our work on isospin violation in the K -> 3 pi system. We first calculate K -> 2 pi to the same order as we did K -> 3 pi in papers I and II of this series. This adds the effects of order G(27)p(2)(m(u) - m(d)) and G(27)p(2)e(2) to earlier work. We calculate also the lowest order bremsstrahlung contributions, K -> 2 pi gamma, 3 pi gamma. With these and our earlier results we perfo
This thesis consists of two parts with the common theme of statistical modelling in chemistry. The first part is concerned with applications in nuclear magnetic resonance (NMR) spectroscopy, while the second part deals with applications in polymerase chain reaction (PCR). The problems considered in the first part all have their origin in protein NMR spectroscopy, although they are treated mainly
BACKGROUND: Data from several studies support the hypothesis that thrombopoietin (TPO) plasma levels are regulated via circulating platelet (PLT) numbers by binding to PLT TPO receptors (TPO-Rs). In this study, PLT numbers and TPO plasma levels were measured following the transfusion of unmanipulated, sham-saturated, and TPO-R-saturated PLT preparations to provide additional in vivo evidence for t
This study presents 20 patients, randomised to receive either a collagen-treated or an ordinary Dacron graft for aortic reconstructions, and the results of a skin-prick test, blood parameters and ELISA for anti-collagen antibodies as well as NMR pictures during a 6 week follow-up period. Forty per cent (4/11) of those receiving a collagen impregnated graft had a significantly increased titre of an
Liquid-liquid partition chromatography in an aqueous poly(ethylene glycol)/dextran two-phase system (LLPC) is shown to be a quick and sensitive method for detecting conformational changes occurring upon binding of ligands by biospecific molecules. Two groups of well-characterized proteins, enzymes and monoclonal antibodies, were employed. As an example, LLPC demonstrated that isoforms of lactate d
The adaptation of three allopatric populations of a generalist moth, Operophtera brumata (L.), on two tree species, Prunus padus (L.) and Quercus robur (L.) which represent the extremes of the timing of budburst in spring, was studied in Finland and Sweden. The synchrony of the hatching and budbursting was monitored, and its importance to dispersal and growth of larvae was assessed by rearing coho
The size effect in shear strength of longitudinally reinforced beams is studied by means of a nonlinear fracture mechanics model. According to the actual theoretical study, structure size should be normalized to an intrinsic length parameter of the concrete. This length parameter is proportional to the fracture energy G//F of the concrete. It is found that the shear strength of a concrete beam may
