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Cell culturing methods are increasingly used to reduce and replace the use of live animals in biomedical research and chemical toxicity testing. Although live animals are avoided when using cell culturing methods, they often contain animal-derived components of which one of the most commonly used is foetal bovine serum (FBS). FBS is added to cell culture media among other supplements to support ce
Sports-related concussions may cause white matter injuries and persistent post-concussive symptoms (PPCS). We hypothesized that athletes with PPCS would have neurocognitive impairments and white matter abnormalities that could be revealed by advanced neuroimaging using ultra-high field strength diffusion tensor (DTI) and diffusion kurtosis (DKI) imaging metrics and cerebrospinal fluid (CSF) biomarSports-related concussions may cause white matter injuries and persistent post-concussive symptoms (PPCS). We hypothesized that athletes with PPCS would have neurocognitive impairments and white matter abnormalities that could be revealed by advanced neuroimaging using ultra-high field strength diffusion tensor (DTI) and diffusion kurtosis (DKI) imaging metrics and cerebrospinal fluid (CSF) biomar
The focus of this work is to characterize the mechanical stresses and fatigue along the enameled wire due to thermal expansion. The stresses and fatigue is estimated for a single wire and as a function of evenly distributed temperature. The estimation is based on both analytical equations and 3D Finite Element (FE) model. This characterization of mechanical stresses and fatigue is then used to exa
Objectives: To analyse the section of Disclosure UK that pertains to healthcare professionals (HCPs) in order to provide insight into the database’s structure and content and suggest ways to improve its transparency.Design and participants; Cohort study of drug companies and HCPs in the 2015 and 2016 versions of Disclosure UK.Results: Companies report transfers of value (ToVs) to named HCPs or, wh
In the ideal-type of bureaucracy, Max Weber outlined the creation of the modern state as an iron-cage of disenchantment and quantification. This thesis updates Weber’s ideal-type on the notion that the modern nation state is declining, and the large institutions with it. Based in an ideal-type of Michel Foucault’s Biopolitics, as Economization (a rational focus on quantitative measures), Individua
The actor’s practice and bodily training during the twentieth century are specifically related not only to different bodily techniques, but also to language, modern society, and the concept of freedom. Nationalism, anti-intellectualism, bodily and vitalistic purism, and a sceptical distance from the modern project at the beginning of the twentieth century serve as a starting point for a discussion
The interaction between cystatin C variants, in which the evolutionarily conserved Gly-11 residue was substituted by Ala, Glu or Trp, and the cysteine proteinases, papain, ficin, actinidin and cathepsin B, was characterized. The substitutions reduced the affinity of binding in a manner consistent with the Gly residue of the wild-type inhibitor, allowing the N-terminal region to adopt a conformatio
This study aimed to explore how social workers reason about the child’s best interests in investigations concerning visitation rights when there is a risk of domestic violence. Using evaluative argumentation analysis, we examined six child welfare investigations to identify the key factors that influence decision-making. Our findings indicate that several considerations are crucial in the assessme
In this written study, I have researched video game music from the 90’s and early 2000’s to see what I can learn from the process of composing music for video games, as well as how the hardware and software capabilities of the game consoles shaped the music. First it presents my own background and relation to the subject, next it establishes what functionally separates video game music from conven
The literary heroic ideal changed with the Great War, as the Victorian hero ideal was no longer plausible in a post-war world. The new ideal was pacifist and non-heroic but not everyone who had been through the Great War agreed that there was no heroicism. This essay discusses the development of the heroic ideal in the mid twentieth century in relation to the two brothers Boromir and Faramir in J.
With the wide-ranging crisis in Venezuela exacerbating since 2014 and Chile consolidating its leading economic position within Latin America, the number of Venezuelan immigrants in Chile has significantly grown. This paper aims to understand the push and pull factors of Venezuelans migrating to Chile and their perceived integration. The broader purpose is to better understand the push and pull fac
I april 2017, blev Rebecca Tuvel, en av författarna till den feministiska filosofiskriften Hypatia, kritiserad för en artikel som hon hade skrivit och som hade publicerats av den akademiska tidskriften. Artikeln som Tuvel skrev, innefattade ett jämförande av Rachel Dolezal, en vit kvinna som identifierade sig som svart, med det av Caitlyn Jenner, en trans kvinna. Detta i sin tur ledde till att för
In order to identify agonist- and antagonist-binding epitopes in the human B1 and B2 bradykinin (BK) receptors, we exploited the ability of these receptors to discriminate between peptide ligands that differ only by the absence (B1) grid presence (B2) of a C-terminal Arg. This was done by constructing chimeric proteins in which specific domains were exchanged between these receptors as recently de
Substantial variability exists in what pathologists consider as pT4a in colorectal cancer when tumor cells are within 1 mm of the free peritoneal surface. This study aimed to determine if the measured sub-millimeter distance between tumor cells and the free peritoneal surface would offer an objective means of stratifying patients according to the risk of developing peritoneal metastases. Histologi
Background In the coming half-century, the population of old people will increase, especially in the oldest age groups. Therefore, the prevalence of multiple chronic conditions, and consequently, the need of health care including care in hospital, is rising. Materials and methods This article includes results from three mainly qualitative articles (interviews with frail old people, physicians, and
Voting cohesion in the European Parliament is a thoroughly studied field, however a deep dive into the kingmaker of coalition building, the liberal party group, has yet to be done. This thesis attempts to illustrate how voting cohesion varies within the Alliance of Liberals & Democrats and Renew Europe respectively, and what factors can explain variation in cohesion. Specifically, how cohesion
