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A major challenge in the development of peptide-based vaccines is finding the right immunogenic element, with efficient and long-lasting immunization effects, from large potential targets encoded by pathogen genomes. Computer models are convenient tools for scanning pathogen genomes to preselect candidate immunogenic peptides for experimental validation. Current methods predict many false positive
The return sludge of one of the four treatment lines at oresundsverket WWTP in Sweden was subjected to ozonation in full-scale to reduce filamentous bulking sludge. The biological nitrogen and phosphorus removal capacity along with effluent parameters were studied throughout the trial. Samples were also taken to track possible changes in microbial population due to ozone. 2.8-5.0 g O-3 kg(-1) trea
It is crucial to perform energy simulations during the building process to design a building that meets requirements regarding low energy use. In a low energy building, internal heat gains such as excess heat from household electricity are a large part of the heat balance of the building. The internal heat gains depend on the occupants and are not constant, although they are often assumed constant
Dynamic loading of elastic-plastic slabs is studied numerically using a finite element approach, where introduction of cohesive elements enables fracture. For the bulk material, J(2)-flow theory is chosen as constitutive model, whereas the behavior of the cohesive elements is described by an irreversible cohesive law. The fracture behavior is governed solely by the cohesive elements, which are inc
This study experimentally investigated convective heat transfer performances of China RP-3 kerosene flowing in a vertical upward tube under supercritical pressures. Effects of mass flux, heat flux, pressure and inlet temperature on the heat transfer performance were given in detail. The influences of buoyancy and flow acceleration under different flow conditions were discussed as well. It was foun
Sexual activity online may result in positive experiences for young people, or lead them to engage in risky behaviours possibly resulting in sexual assault or abuse. The aim of our study was to investigate associations between online sexual behaviours among Swedish youth and background factors as well as aspects of wellbeing. The behaviours investigated were: having sex online with a contact met o
Objective. Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. Methods. We characterized clinical features, tumor morphology and mismatch repair defects in all ovarian cancers identified in Swedish and Danish Lynch syndrome families. Results. In total, 63 epit
OBJECTIVETo investigate associations of maternal gestational weight gain and body composition and their impact on offspring body composition and adipocytokine, glucose, and insulin concentrations at age 4 months.RESEARCH DESIGN AND METHODSThis was a prospective study including 31 mother-infant pairs (N = 62). Maternal body composition was assessed using doubly labeled water. Infant body compositio
Non-typable Haemophilus influenzae (NTHi) is an important human-specific respiratory pathogen colonizing the mucosa of the upper respiratory tract. The bacterium is a common cause of acute otitis media in children and exacerbations in patients with chronic obstructive pulmonary disease (COPD). An immunoglobulin (Ig) D-lambda myeloma protein was found to detect a 16kDa surface protein that we desig
For group-living animals, the maintenance of a position in the social hierarchy may be associated with physiological costs such as increased stress and energy expenditure or suppressed immune functions. In this study, we experimentally manipulated the social status of house sparrows so that each bird experienced two social environments in random sequence: being dominant and subordinate. For 14 mal
A single intradermal injection of the adjuvant-oil squalene induces T cell mediated arthritis in DA rats. The chain of events leading from nonspecific provocation of the immune system to arthritis is largely unknown. Previous studies have demonstrated that lymph node (LN) cells are of pathogenic importance, i.e. cells from LNs draining the injection site can transfer arthritis to naïve DA rats. Re
Objective To review publications regarding possible donation of surplus embryos for medical research. Design Review of 67 scientific publications in this field up through January 2007. Originality Summary of factors influencing prospective donors' motivation to donate or not donate their surplus embryos for medical research. Result(s) Presentation of the findings of studies regarding the need
Bronchoalveolar lavage was performed in 51 patients with sarcoidosis and in 21 healthy nonsmokers. The concentration of fibronectin was significantly higher (p less than 0.001) in lavage fluid from sarcoid patients (median 267 micrograms.l-1) than in that of controls (46 micrograms.l-1). Furthermore, a significantly higher concentration of fibronectin was found in patients with active disease than
