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För kroppens vävnader är omvandling av syrgas och näringsämnen till energi av stor vikt, och detta särskilt vid sjukdomsprocesser. Vi vill klargöra mitokondriens roll för organpåverkan, framför allt vid sjukdomar som drabbar det centrala nervsystemet men även vid organsvikt till följd av sepsis samt läkemedelsbiverkan. Forskningen är inriktad mot utveckling av nya strategier för diagnostik, behandThe energy-producing mitochondria are central to maintenance and survival of cells and have been proposed to participate in the pathogenesis of organ dysfunction. We use sensitive systems for analysis of mitochondrial function and have developed high-resolved respirometry applied to human blood cells. With this rapid and easy accessible method to monitor systemic mitochondrial function we determin

Parkinson: På kurs mot bot. Vår forskningsgrupp fokuserar sitt intresse på Parkinsons sjukdom (PS), den näst vanligaste neurodegenerativa sjukdomen, med cirka 20 000 patienter i Sverige och 2,3 miljoner i Europa.Parkinson: On course against Cure. Our research group focuses on Parkinson's disease (PD), the second most common neurodegenerative disease, with approximately 20 000 patients in Sweden and 2.3 million in Europe.

Title: A quantitative Study of the distribution of information at Sweden’s needle exchange programs. [Translated title] The Swedish needle exchange program focuses on helping individuals who inject drugs to reduce the risk of illnesses and infections, by offering them clean injecting tools, get in touch with different authorities and organisations that can provide help and support to better their

Biological and physical processes in the Arctic system operate at various temporal and spatial scales to impact large-scale feedbacks and interactions with the earth system. There are four main potential feedback mechanisms between the impacts of climate change on the Arctic and the global climate system: albedo, greenhouse gas emissions or uptake by ecosystems, greenhouse gas emissions from metha

Sleep has a major impact on our wellbeing and how we perform.

A service transition is supposed to lead to the decline of energy intensity (energy/GDP). We argue that this interpretation is overly optimistic because the shift to a service economy is somewhat of an illusion in terms of real production. Several recent studies of structural effects on energy intensity have made the error of using sector shares in current prices, combined with GDP in constant pri

Considerations of the backscattering data for the Schrodinger operator H-v = -Delta + v in R-n, where n >= 3 is odd, give rise to an entire analytic mapping from C-0(infinity)(R-n) to C-0(infinity)(R-n), the backscattering transformation. The aim of this paper is to give formulas for B-2(v, w) where B-2 is the symmetric bilinear operator that corresponds to the quadratic part of the backscattering

Web Development and the way it’s been applied nowadays has been remarkably affected by the trend of harnessing user’s output through the implementation of Web Analytics. Under-standing the degree in which the process of web development is driven by data demands a detailed examination on topics within the area of Web Analytics and its correlations with Web Development. Accordingly, the strategicall

The value added of the Swedish industrial sector has earlier been calculated by Osten Johansson (ÖJ)2 and the Economic Research Institute (Konjunkturinstituiet, KI). 3 However, these calculations have proved to be in need of revision on various points. In the following pages new calculations are shown for a shorter period, 1941–51. Furthermore, an attempt has been made to construct a new price ind

In the standard Lambda cold dark matter paradigm, pure dark matter simulations predict dwarf galaxies should inhabit dark matter haloes with a centrally diverging density 'cusp'. This is in conflict with observations that typically favour a constant density 'core'. We investigate this 'cusp-core problem' in 'ultra-faint' dwarf galaxies simulated as part of the 'Engineering Dwarfs at Galaxy formati

Strategisk kommunikation har länge förföljts av ryktet att vara omoraliskt, ofta använt synonymt med nedsättande ord som sofistik och propaganda. Forskare inom samhällsvetenskapen har tränats att acceptera denna beskrivning av strategisk kommunikation som en normativ utgångspunkt, genom inflytelserika teorier som Habermas diskursetik och metodologier som kritisk diskursanalys. Denna avhandling utmStrategic communication has long suffered from a reputation of immorality, often being conflated with derogatory terms such as sophistry and propaganda. Scholars in the social sciences have been trained to accept this moralizing idea of strategic communication as a normative point of departure, through influential theories such as Habermas’ discourse ethics and methodological approaches such as cr

Patients with chronic hepatic encephalopathy often display altered diurnal rhythm as well as other affective disturbances which motivate treatment with antidepressants. We investigated the effects of sustained treatment with citalopram (10 mg/kg daily, 10 days) on 24-hr behavioural open-field activities in portacaval-shunted (PCS) rats and sham-operated control rats. In addition, the daytime and n