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BACKGROUND: There are inconsistent data regarding the association between metabolic factors, separately and combined, and the risk of prostate cancer and death from prostate cancer. METHODS: In the Metabolic Syndrome and Cancer Project (Me-Can), data on body mass index (BMI); blood pressure; and blood levels of glucose, cholesterol, and triglycerides were collected for 289,866 men. Cox proportiona
Background: Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) enables sensitive detection and staging of prostate cancer, yet its relationship with long-term survival remains unclear. This study aimed to assess whether total lesion volume (TLV) measured on [18F]PSMA-1007 PET/CT predicts overall survival (OS) in prostate cancer patients. Methods: A co
In mitosis, transcription factors (TFs) and RNA polymerase disperse across the cytoplasm leading to transcriptional silencing, but some TFs are retained on condensed chromatin and mark genomic sites, a mechanism termed mitotic bookmarking. In pluripotent and differentiated cells this mechanism is important for pluripotency maintenance, cell reprogramming and lineage inheritance. However, the role
Late mortality of European 5-year survivors of childhood or adolescent cancer has dropped over the last 60 years, but excess mortality persists. There is little information concerning secular trends in cause-specific mortality among older European survivors. PanCareSurFup pooled data from 12 cancer registries and clinics in 11 European countries from 77 423 five-year survivors of cancer diagnosed
Background: The range of onset ages within some PSEN1 families is wide, and a few cases of reduced penetrance of PSEN1 mutations have been reported. However, published data on reduced penetrance have been limited to clinical histories, often collected retrospectively and lacking biomarker information. We present a case of reduced penetrance of the PSEN1 H163Y mutation in a carrier prospectively fo
INTRODUCTION: The aim was to investigate psychiatric health care utilization two years before death by suicide among individuals with previous suicide attempts (PSA) compared with those without (NSA).METHOD: A retrospective population-based cohort study was conducted including 484 individuals who died by suicide in Sweden in 2015 and were in contact with psychiatric services within the two years p
Purpose Despite data showing breathlessness to be more prevalent in older adults, we have little detail about the severity or multidimensional characteristics of breathlessness and other self-reported measures (such as quality of life and other cardiorespiratory-related symptoms) in this group at the population level. We also know little about the relationship between multidimensional breathlessne
Popular Abstract in Swedish Akut bukspottkörtelinflammation är en sjukdom som drabbar ungefär 35 per 100 000 invånare i Sverige årligen. Förloppet innebär i flertalet fall ett komplikationsfritt tillfrisknande. Cirka 20% drabbas dock av en allvarlig form som kräver stora sjukvårdsresurser och innebär avsevärd sjuklighet, inkluderande risk för vävnadsdöd i bukspottkörteln, lokala och spridda infektAcute pancreatitis, with an annual incidence of approximately 35 per 100 000 inhabitants in Sweden, is in most cases mild and self-limiting. Severe acute pancreatitis, affecting 10-15% of the cases is, however, associated with severe complications and even death. The optimal management of acute pancreatitis includes accurate early prediction of the disease severity. The aims of this thesis were to
Background: Prostate-specific antigen (PSA) based screening for prostate cancer (PCa) has been shown to reduce prostate specific mortality by 20% in an intention to screen (ITS) analysis in a randomised trial (European Randomised Study of Screening for Prostate Cancer [ERSPC]). This effect may be diluted by nonattendance in men randomised to the screening arm and contamination in men randomised to
Background: There are limited prognostic data for locally advanced prostate cancer PCa to guide in the choice of treatment. Objective: To assess mortality in different prognostic categories among men with locally advanced PCa managed with noncurative intent. Design, setting, and participants: We conducted a register-based nationwide cohort study within the Prostate Cancer DataBase Sweden. The enti
Att tvångsomhänderta ett barn är ett undantag från svensk inställning att vård ska ske genom frivillighet. Det är inget som görs lättvindigt och det krävs att det finns en påtaglig risk för att barnets hälsa eller utveckling annars kommer till skada. Men hur stora krav finns det i samband med vårdens avslutande, var ligger fokus när den bedömningen görs? Syftet med detta arbetet är att titta på föTo take a child into public care against the parents will is an exception from the Swedish standpoint that all care should be given on a voluntary basis. It requires that there is a noticeable risk that the child's health or development will come to harm. But what are the demands when deciding whether the care should come to an end? Where is the focus in that process? The aim of this study is
I familjerätten finns två former av vårdnad, ensam vårdnad och gemensam vårdnad. Den sistnämnda vårdnadsformen utgör utgångspunkten vid bedömningen av vilken vårdnadsform som är lämpligast. En utgångspunkt som har varit så stark att den har gett upphov till en presumtion för gemensam vårdnad. Uppsatsen undersöker den gemensamma vårdnadens rättsutveckling med utgångspunkt i vårdnadsreformerna 199Within the area of family law there exists two forms of legal child custody, sole custody and joint custody. The last form is the starting point in court when deciding upon which form of custody constitutes the most suitable one. The strength of the previously mentioned starting point are of such degree that a presumption for joint custody took shape. The essay examines how the development of chi
CFE-Paper A5 ver 7 1Hollywood Horror: Europe as American Dystopia Hollywood Horror: Europe as American Dystopia Michael Tapper Michael.Tapper@swipnet.se 2 CFE Working paper series no. 7 CENTRE FOR EUROPEAN STUDIES AT LUND UNIVERSITY: Box 52 Phone: +46 (0)46-222 88 99 SE-221 00 LUND Fax: +46 (0)46-222 40 06 Sweden Email: cfe@cfe.lu.se CFE Working paper series is published by Centre for European Stu
https://www.cfe.lu.se/en/sites/cfe.lu.se.en/files/2020-12/cfewp07.pdf - 2026-05-30
Background: Artificial intelligence (AI) is rapidly infiltrating multiple areas in medicine, with gastrointestinal endoscopy paving the way in both research and clinical applications. Multiple challenges associated with the incorporation of AI in endoscopy are being addressed in recent consensus documents. Objectives: In the current paper, we aimed to map future challenges and areas of research fo
Cardiac resynchronization therapy (CRT) reduces mortality and morbidity in selected patients with heart failure (HF), but up to 1/3 of patients are nonresponders. Sum absolute QRST integral (SAI QRST) recently showed association with mechanical response on CRT. However, it is unknown whether SAI QRST is associated with all-cause mortality and HF hospitalizations in patients undergoing CRT. The stu
ObjectivePediatric anxiety disorders can have a chronic course and are considered gateway disorders to adult psychopathology, but no consistent predictors of long-term outcome have been identified. A single latent symptom dimension that reflects features shared by all mental health disorders, the p factor, is thought to reflect mechanisms that cut across mental disorders. Whether p predicts outcom
Purpose: To verify the accuracy of clinically used cardiac MRI T1 mapping sequences for measuring extracellular volume fraction (ECV) throughout the spectrum of pathologic values using an independent reference standard. Materials and Methods: Acute myocardial ischemia was induced in six pigs using endovascular balloon occlusion in the left anterior descending artery between October 2018 and Novemb
BACKGROUND: Cerebral injury is the most important complication of cardiac operations with cardiopulmonary bypass. Prolonged total circulatory arrest (TCA) can expose patients to an even greater risk of cerebral injury. We sought to detect the degree of cerebral injury in adults who had thoracic aortic operations with TCA by measuring S100B protein, which is released into the circulation after cere
Background: Characteristics and prognosis of patients admitted with strong suspicion of myocardial infarction (MI) but discharged without an MI diagnosis are not well-described. Objectives: To compare background characteristics and cardiovascular outcomes in patients discharged with or without MI diagnosis. Methods: The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction (
Objective: More than 50% of patients with rheumatoid arthritis (RA) are >65 years at diagnosis. Age of onset and sex may influence the disease course, outcome and treatment. This study follows a large cohort of patients with early RA to assess contributions of age and sex to disease outcomes. Methods: Patients from the BARFOT cohort, n=2837 (68% women), were followed for eight years at predefined
