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Russian internet news sites, 2008–2018 : Fostering an informed citizenry?

Since Perestroika, Russian journalism has gone through a liberalization. However, the short lived apex of journalistic freedom that took place in the late 1980s and early 1990s was followed by a setback in particular since Putin’s accession to power in 2000. The situation for the freedom of the daily press has stagnated. Despite this, the findings based on qualitative text analysis of news article

The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

The recognition of carbohydrates by proteins is a fundamental aspect of communication within and between living cells. Understanding the molecular basis of carbohydrate-protein interactions is a prerequisite for the rational design of synthetic ligands. Here we report the high- to ultrahigh-resolution crystal structures of the carbohydrate recognition domain of galectin-3 (Gal3C) in the ligand-fre

Simultaneous assimilation of remotely sensed soil moisture and FAPAR for improving terrestrial carbon fluxes at multiple sites using CCDAS

The carbon cycle of the terrestrial biosphere plays a vital role in controlling the global carbon balance and, consequently, climate change. Reliably modeled CO2 fluxes between the terrestrial biosphere and the atmosphere are necessary in projections of policy strategies aiming at constraining carbon emissions and of future climate change. In this study, SMOS (Soil Moisture and Ocean Salinity) L3

The Active Site of a Carbohydrate Esterase Displays Divergent Catalytic and Noncatalytic Binding Functions

Multifunctional proteins, which play a critical role in many biological processes, have typically evolved through the recruitment of different domains that have the required functional diversity. Thus the different activities displayed by these proteins are mediated by spatially distinct domains, consistent with the specific chemical requirements of each activity. Indeed, current evolutionary theo

Computational Study of the pKa Values of Potential Catalytic Residues in the Active Site of Monoamine Oxidase B

Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine. Despite extensive research effort, neither the catalytic nor the inhibition mechanisms of MAO have been completely understood. There has also been dispute with regard to the protonation s

Modelling flow routing in permafrost landscapes with TWI : an evaluation against site-specific wetness measurements

In northern peatlands the thawing of permafrost increasing the active layer depth and changing the hydrology may lead to feedbacks in the climate system through changes in the biogeochemistry of carbon. We are examining this association on the Stordalen peatland complex in subarctic Sweden by analyzing a DEM derived from LiDAR-data and the calculated TWI. The DEM, with a spatial resolution of 1 m,

Generalization of prostate cancer classification for multiple sites using deep learning

Deep learning has the potential to drastically increase the accuracy and efficiency of prostate cancer diagnosis, which would be of uttermost use. Today the diagnosis is determined manually from H&E stained specimens using a light microscope. In this paper several different approaches based on convolutional neural networks for prostate cancer classification are presented and compared, using th