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Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown. We investigated the effects of asthma-associated SNPs on DNA methylation and mRNA levels of GSDMB and ORMDL3. Genetic association between GSDMB/ORMDL3 and physician

Succession is one of the most studied processes in ecology and succession theory provides strong predictability. However, few attempts have been made to influence the course of succession thereby testing the hypothesis that passing through one stage is essential before entering the next one. At each stage of succession ecosystem processes may be affected by the diversity of species present, but th

We have previously shown that protein kinase Cepsilon (PKCepsilon) induces neurite outgrowth via its regulatory domain and independently of its kinase activity. This study aimed at identifying mechanisms regulating PKCepsilon-mediated neurite induction. We show an increased association of PKCepsilon to the cytoskeleton during neuronal differentiation. Furthermore, neurite induction by overexpressi

Oxy-fuel combustion is one of the proposed technologies with the potential to achieve zero CO2 emission. La1−xCaxCo1−yFeyO3−δ (LCCF) perovskites are promising materials with high selectively for oxygen. In this study, the oxygen non-stoichiometry of perovskites LCCF was investigated by means of iodometric titration. LCCF was prepared using the liquid citrate method, and the phase structures were i

Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. Besides creating useful catalysts, the generation and iterative improvement of designed enzymes can provide valuable insight into the interplay between the many phenomena that have been suggested to contribute to catalysis. In this work, we fo

The specific binding of [3H]α-dihydropicrotoxinin to rat brain membranes was inhibited competitively and potently (IC50 ≅ 100 nM) by a convulsant benzodiazepine drug, RO5-3663. This compound did not inhibit high affinity flunitrazepam binding to the same tissue under similar conditions, and its reported pharmacological activity as an antagonist of GABAergic synaptic transmission, which resembles t

I snart 500 år har människan använt sig av diverse optiska instrument för att betrakta sådant som inte är möjligt att se med blotta ögat. Teleskop har använts för att studera himlakroppar och mikroskop för att exempelvis undersöka små biologiska beståndsdelar. Det finns idag många olika metoder inom optisk mikroskopi men samtliga följer en liknande grundprincip. Objektet som ska avbildas exponerasSeveral significant pathogenic bacteria exhibit surface proteins that bind human antibodies, preventing them from being recognized by the human immune system. These bacteria are thus protected from elimination and can survive in the host organism. One common such bacteria is the Streptococcus pyogenes that exhibits the antibody binding M protein on its surface. Streptococcus pyogenes causes more t

Cultural tourism and cultural heritage management, while distinct disciplines with differing foci, are also inherently intertwined. However, conflicts between the two often arise due to the diverse number of stakeholders and interests involved in either the travel industry or the conservation and protection of cultural heritage. Despite this, cultural tourism can greatly benefit the conservation o

Kan cellers proteiner bota HPV- sjukdomar? Livmoderhalscancer är en av de vanligaste cancersjukdomarna som drabbar kvinnor världen över. Varje år, diagnostiseras ungefär 500 000 kvinnor och 270 000 dör i sjukdomen, varav de flesta dödsfallen sker i utvecklingsländer. Livmoderhalscancer orsakas av det vanligt förekommande viruset humant papillomvirus (HPV) och för att hitta bättre behandling mot sHuman papillomaviruses (HPVs) are small DNA viruses that have evolved over millions of years and are well-adapted to humans. Persistent infections with HPVs, can result in cancer development. There are over 200 different HPV types that can be divided into high- and low risk types based on their ability to cause cancer. HPV16 is the most common high- risk type that accounts for more than 50 % of al