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The major histocompatibility complex (MHC) is a membrane protein group of central importance in the immune system. It is divided into two main classes, class I and class II. The MHCs are highly polymorphic which is believed to be indication of trans-species polymorphism (TSP). There is TSP when an allele is maintained in two species through a speciation event. The songbirds that I study here belon
Detta är en artikel om kalkmodifiering av lermorän och är baserad på examensarbetet ”Lime modification of clay till – a case study” (Westesson, 2015). Med kalkmodifiering menas att jordens packningsbarhet förbättras genom inblandning av kalk. Metoden att använda sig av kalk för att förbättra de geotekniska egenskaperna av leror och lermoräner är en nygammal metod och har främst använts till vägproThis report deals with lime modification of clay till. Lime modification means that the compaction properties of the soil are improved by the addition of lime. The report consists of three main parts: 1) Description of the geotechnical properties of clay till and how lime modification affects the properties; 2) Description of the implementation of lime modification and the tests conducted at a con
In our everyday life we live distant from the origin of life itself - nature. Dramatic landscape and fascinating views touch us in a way that few other things manage to do. It is something that make us recognize our powerlessness and the feeling of awe towards the nature. Experiencing striking nature is a way to create a deeper understanding of our own world and at the same time enrich our lives w
A part of the project of transforming the worn down medieval fortress Glimmingehus into a tourist attraction for the people of the 20th century, was to dig out the once filled in moat surrounding it. This very labour intensive project did not only result in a nostalgic atmosphere but also a large amount of fairly well preserved finds, since the moat had once been used as a rubbish dump. A part of
Effekterna av mikroplaster är ännu inte helt utredda och därför kan de vara mycket farligare än vad vi vet idag. Plastpartiklarna kan finnas överallt i miljön och en hittills outforskad spridningskälla är deponier och dess lakvatten. Det har inte undgått allmänheten att större plastskräp, det vill säga makroplaster, både förfular samt förstör natur och miljö. Mindre plastskräp, så kallade mikropAlthough most microplastics (<5 mm in length or diameter, depending on shape) are not visible they can be found everywhere in the environment. The effects can be devastating and much greater than what has been proven so far, as there is a lack of knowledge about the impact, spread and extent of microplastics. The Swedish EPA published a report in June 2017 which reveals a number of major microplas
Lakvatten läcker ut mikroplast Effekterna av mikroplaster är ännu inte helt utredda och därför kan de vara mycket farligare än vad vi vet idag. Plastpartiklarna kan finnas överallt i miljön och en hittills outforskad spridningskälla är deponier och dess lakvatten. Det har inte undgått allmänheten att större plastskräp, det vill säga makroplaster, både förfular samt förstör natur och miljö. MindrAlthough most microplastics (<5 mm in length or diameter, depending on shape) are not visible they can be found everywhere in the environment. The effects can be devastating and much greater than what has been proven so far, as there is a lack of knowledge about the impact, spread and extent of microplastics. The Swedish EPA published a report in June 2017 which reveals a number of major microplas
A 30-m-thick sedimentary succession at Leinstranda on the southwestern coast of Br circle divide ggerhalv circle divide ya, northwestern Svalbard, spans the two last glacial-interglacial cycles and reveals information on glacial dynamics, sea-level changes and the timing of these events. We investigated the deposits using standard stratigraphical and sedimentological techniques, together with grou
A first research development progress report of the Chromosome 19 Consortium with members from Sweden, Norway, Spain, USA, China and India, a part of the Chromosome-Centric Human Proteome Project (C-HPP) global initiative is presented (http://www.c-hpp.org). From the chromosome 19 peptide-targeted library constituting 6159 peptides, a pilot study was conducted using a sub-set with 125 isotope-labe
Life-threatening intracardiac and great vessels thrombi are rare in neonates. Recombinant tissue plasminogen activator (rTPA) is used in adults to stimulate fibrinolysis and facilitate thrombus resolution. Its use in neonates, along with heparin, remains controversial because of potential risk of serious bleeding. We aim to present our experience with the use of thrombolytic agents in seven neonat
OBJECTIVES: To investigate the mechanisms of platelet kinetics in the SMART study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) (drug conservation [DC]) compared to continuous treatment (viral suppression [VS]). Follow up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART.
Colonies of N-2-fixing cyanobacteria are key players in supplying new nitrogen to the ocean, but the biological fate of this fixed nitrogen remains poorly constrained. Here, we report on aerobic and anaerobic microbial nitrogen transformation processes that co-occur within millimetre-sized cyanobacterial aggregates (Nodularia spumigena) collected in aerated surface waters in the Baltic Sea. Microe
Aim of the study: The primary purpose of this study is to investigate if pretreatment plasma levels of vascular endothelial growth factor (VEGF) are predictive of the effect of celecoxib on survival in advanced non-small cell lung cancer (NSCLC) treated with palliative chemotherapy. A secondary objective is to describe the course of plasma VEGF levels during and after treatment with cytotoxic chem
BackgroundPost-relapse survival (PRS) was evaluated in patients with Ewing sarcoma (EWS) enrolled in chemotherapy protocols based on the use of high-dose chemotherapy with busulfan and melfalan (HDT) as a first-line consolidation treatment in high-risk patients. ProcedureEWS patients enrolled in ISG/SSG III and IV trials who relapsed after complete remission were included in the analysis. At recur
Loop migration among birds is characterized by the spring route lying consistently west or east of the autumn route. The existence of loops has been explained by general wind conditions or seasonal differences in habitat distribution. Loop migration has predominantly been studied at the population level, for example by analysing ring recoveries. Here we study loop migration of individual marsh har
In aqueous systems with immobilized macromolecules, including biological tissue, the longitudinal spin relaxation of water protons is primarily induced by exchange-mediated orientational randomization (EMOR) of intra- and intermolecular magnetic dipole-dipole couplings. We have embarked on a systematic program to develop, from the stochastic Liouville equation, a general and rigorous theory that c
Prior work demonstrated increased levels of hypoxia-inducible factor-1α (HIF-1α) in the bladder following outlet obstruction, associated with bladder growth and fibrosis. Here we hypothesized that HIF induction in outlet obstruction also switches energetic support of contraction from mitochondrial respiration to glycolysis. To address this hypothesis, we created infravesical outlet obstruction in
The massive amount of genomic sequence data that is now available for analyzing evolutionary relationships among 31 placental mammals reduces the stochastic error in phylogenetic analyses to virtually zero. One would expect that this would make it possible to finally resolve controversial branches in the placental mammalian tree. We analyzed a 2,863,797 nucleotide-long alignment (3,364 genes) from
The photochemical oxidation of oceanic dissolved organic carbon (DOC) to carbon monoxide (CO) and carbon dioxide (CO2) has been estimated to be a significant process with global photoproduction transforming petagrams of DOC to inorganic carbon annually. To further quantify the importance of these two photoproducts in coastal DOC cycling, 38 paired apparent quantum yield (AQY) spectra for CO and CO
