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A large share of the existing building stock in Sweden originates from the so-called Million Building Programme, a large-scale construction wave between 1965 and 1974 to tackle the housing shortage at this time. Those buildings have very high energy demand and require renovation due to age and often neglected maintenance. The Swedish government’s long-term climate and energy goals are tied to an e
Bygg- och fastighetssektorn står för stora utsläpp av växthusgaser från byggnadsmaterial- och energianvändning. Byggbranschen står idag för ca en femtedel av Sveriges totala koldioxidutsläpp. Ett område med stor potential är byggnadsmaterial där IsoTimber är ett av företagen som driver utvecklingen framåt. IsoTimber är en relativt ny aktör inom byggsektorn som tillverkar prefabricerade väggar i trThe construction and real estate sector accounts for a large part of the emission of greenhouse gases from the usage of building material and energy. The construction industry today accounts for about one-fifth of Sweden’s total carbon dioxide emissions. One area with great potential is building materials where IsoTimber is one of the companies that drive the development forward. IsoTimber is a re
All around the world is the form of the built environment playing a significant role in either enabling or inhibiting outdoor activities. When it comes to winter and Winter cities, it is a challenge how to enable and encourage outdoor activities and soft mobility as the harsh conditions often make it uncomfortable to spend longer periods of time outdoors. A major urban design challenge in Winter
Försurning och övergödning utgör betydande hot mot världens ytvatten och svenska vatten är bland de mest utsatta. I den här studien har avrinningsområdet Storskogen analyserats för att undersöka sambandet mellan atmosfäriskt nedfall, hydrologi och ytvattenkemi. Med atmosfäriskt nedfall menas de luftburna föroreningar som landar på avrinningsområdet antingen för att de fångas upp av trädkronorna eWater chemistry alterations such as acidification and eutrophication represent major threats to the running waters of the world, and Swedish waters are among the most vulnerable. In this study the small forested catchment Storskogen, part of the SWETHRO monitoring network, was analysed to examine the links between deposition, catchment hydrological properties and surface water chemistry. Storskoge
Järn är essentiellt för livet som vi känner det idag. Det är en del i flera av de huvudsakliga energisystemen som finns i de flesta levande organismer. Men järn som är fritt i en cell kan orsaka enorma skador genom att det deltar i en process som bildar så kallade syreradikaler. Det finns därför en mängd olika proteiner som på olika sätt binder och reglerar järn. Fel med dessa proteiner kan leda tFriedriech's ataxia is a serious neurological condition that is caused by a deficiency in the expression of the protein frataxin. This deficiency is caused by an extension of GAA repeats in the first intron of the frataxin-coding gene. The disease can have an onset as early as five years and by the time the patient has reached 20 years they often require a wheelchair and help to be able to hav
With the climate change and urbanization process, the frequency of the urban flooding’s occurrence has increased in the recent years. It brings great economic losses to the cities, especially to the basements of individual properties. Low Impact Development (LID), which currently advocated by more city planners for managing stormwater, is considered as a more sustainable way to mitigate urban floo
The genus Caldicellulosiruptor and especially Caldicellulosiruptor saccharolyticus are gaining attention because of their potential as biohydrogen producers from agricultural and forestry waste on an industrial scale. Genetic and in turn metabolic engineering can be used to aid in the characterization of C. saccharolyticus. Additionally, it can be used in strain improvement to overcome limiting fa
MicroRNAs (miRNAs) är små, enkelsträngade RNA molekyler som består av cirka 22 molekylära byggstenar, nukleotider. Nukleotiderna består antingen av adenin (A), guanin (G), cytosin (C) eller uracil (U). Dessa små RNA molekyler är involverade i flertalet sjukdomar och genom att hitta sekvensen av dessa A, G, C, T i ett biologiskt prov, kan miRNAt agera som markör för att hitta nya behandlingsmetoderMicroRNAs are small single stranded RNA molecules containing approximately 22 nucleotides and these play an important regulatory role in gene expression. MicroRNAs are found to be involved in several diseases and knowledge about their sequences can be an important tool in the foundation of novel treatment methods against diseases. Today, these small RNA molecules are mainly analyzed with qPCR and
Vid marktekniska undersökningar i finkorniga jordar är det av stor vikt att korrekt kunna bestämma den odränerade skjuvhållfastheten. Detta görs idag vanligtvis ute i fält med en uppsjö av sonderingsmetoder som ger olika mått på hur fast jorden är. För homogena leror och sand finns det en stadig empirisk grund för hur dessa sonderingsparametrar räknas om till odränerad skjuvhållfasthet, men hur seThe undrained shear strength is a key parameter in the design process of geotechnical structures. One of the most frequently used methods to investigate this parameter is the cone penetration test (CPT). The CPT does not measure the undrained shear strength directly, but instead the resistance that a conic probe encounters as it is pushed into the ground. A calibration factor, the cone factor (Nkt
Begreppet segregation har under senare år tagit allt större plats i samhällsdebatten i Sverige. De bakomliggande drivande faktorerna för fenomenet är komplexa och svåra att förklara och att förändra bostadsbeståndet genom nybyggnation tar tid. Trots försök från politiskt håll och från stadsplanerare att motverka boendesegregationen i städer har inga bestående förändringar påvisats. Förutom det dirThe concept of segregation has in recent years been a subject of social debate in Sweden. The underlying driving factors for the phenomenon are complex and difficult to derive and changing the housing stock through new construction takes time. Despite attempts by politicians and city planners to counteract housing segregation in cities, no permanent changes have been concluded. A part from the nei
III-V semiconductors are a profound part of the optoelectronics industry and new developments in alloy compositions and architectures are constantly emerging. Lowdimensional semiconductors, such as nanowires (NWs) have shown to have improved characteristics in certain areas such as enhanced light absorption and can furthermore be integrated on Silicon (Si) plattforms and are thus predicted to be a
Det övergripande syftet med detta examensarbete är att sammanställa en utvärdering av de utmaningar som det innebär att arbeta med utländsk arbetskraft på svenska byggarbetsplatser. Vidare ämnar arbetet också kartlägga huruvida huvudentreprenörens arbetsledning påverkas av arbetssättet. Studien initierades med en litteraturstudie för att få en utökad teoretisk bakgrund. Vidare genomfördes en fall
Amelogenin is an extracellular matrix protein which has an important role to play in enamel formation during tooth development. The need for amelogenin for research purposes in order to be utilized for its many potential applications have resulted in the rise of the production of recombinant amelogenin. So far, the most optimal expression system used for the production of recombinant amelogenin is
Chagasin is a protein produced by Trypanosoma cruzi, the parasite that causes Chagas' disease. This small protein belongs to a recently defined family of cysteine protease inhibitors. Although resembling well-known inhibitors like the cystatins in size (110 amino acid residues) and function (they all inhibit papain-like (Cl family) proteases), it has a unique amino acid sequence and structure. We
The distribution of sediment-dispersed extraterrestrial chromite grains and other Cr-rich spinels (> 63 mu m) has been studied in Middle Ordovician Orthoceratite Limestone from two quarries at Kinnekulle, southern Sweden. In the Thorsberg quarry, all similar to 3.2 m thick sequence of beds previously shown to be rich in fossil meteorites is also rich in sediment-dispersed extraterrestrial chromite
Affinity proteins were covalently immobilised on silicon microchips with overall dimensions of 13.1 x 3.2 mm, comprising 42 porous flow channels of 235 mum depth and 25 pm width, and used to develop microfluidic immunosensors based on horseradish peroxidase (HRP), catalysing the chemiluminescent oxidation of luminol/p-iodophenol (PIP). Different hydrophilic polymers with long flexible chains (poly
[NiFe] hydrogenases catalyse the reaction H2 <-> 2H(+) + 2e(-). Several states of the enzyme have been observed by spectroscopic methods. Among these, the two most oxidized states, called the unready Ni-A and Ni-SU states, have been especially intriguing, because they take a much longer time to activate than the corresponding ready Ni-B and Ni-SI states. It has recently been suggested that the unr
Background: An allogeneic antitumour effect has been reported for various cancers. We evaluated the experience of allogeneic haematopoietic stem cell transplantation (HSCT) for renal cell carcinoma (RCC) in 124 patients from 21 European centres. Patients and methods: Reduced intensity conditioning and peripheral blood stem cells from an HLA-identical sibling (n = 106), a mismatched related (n = 5)
Context: SHBG regulates free sex steroid levels, which in turn regulate skeletal homeostasis. Twin studies have demonstrated that genetic factors largely account for interindividual variation in SHBG levels. Glucuronidated androgen metabolites have been proposed as markers of androgenic activity. Objective: Our objective was to investigate whether polymorphisms in the SHBG gene promoter [(TAAAA)(n
