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The design and construction of large infrastructure projects require detailed information on subsurface geology and identification of potential risks. Geophysical investigations can provide important information for design and risk assessment provided that the optimal method and interpretation approach is adopted.This work presents results from seismic refraction surveys carried out along a planneThe design and construction of large infrastructure projects require detailed information on subsurface geology and identification of potential risks. Geophysical investigations can provide important information for design and risk assessment provided that the optimal method and interpretation approach is adopted.This work presents results from seismic refraction surveys carried out along a planne

ATTACHMENT of foot-and-mouth disease virus (FMDV) to its cellular receptor involves a long and highly antigenic loop containing the conserved sequence, Arg-Gly-Asp, a motif known to be a recognition element in many integrin-dependent cell adhesion processes1-7. In our original crystal structure of FMDV the Arg-Gly-Asp-containing loop ('the loop'), located between β-strands G and H of capsid protei

The N-terminal RNA binding domain of U1A has been shown to fold in a two-state process without accumulating any intermediates. U1A has a symmetrically curved chevron plot which seems to result mainly from changes of the transition state. At low concentrations of denaturant the transition state occurs early in the folding reaction, whereas at high denaturant concentration it moves close to the nati

The cytokine IL-23 plays important roles in intestinal barrier protection and integrity, but is also linked to chronic inflammation. In this issue of JEM, Ohara et al. (https://doi.org/10.1084/jem.20230923) provide clarity on the much-debated question of which cells produce IL-23.

The catalytic oxidation of HCl by molecular oxygen (Deacon process) over ceria allows the recovery of molecular chlorine from the omnipresent HCl waste produced in various industrial processes. In previous density functional theory (DFT) model-calculations by Amrute et al. [ J. Catal. 2012, 286, 287−297.], it was proposed that the most critical reaction step in this process is the displacement of

When investigating a settlement dated to the late Mesolithic,c.5500 cal BC, at Strandvägen in south-central Sweden, an extensive assemblageof implements made of bone and antler was found. Among these finds was a richlydecorated antler piece, likely part of an antler axe. Originally it was equippedwith shallow ornamentation that was later removed and replaced by a seconddeeper motif of longitudinal

Robins captured as passage migrants by the Baltic Sea in Sweden at Falsterbo and Ottenby Bird Observatories, respectively, differ with respect to body mass, fat load and orientation behaviour. Relatively more birds with large visual fat deposits are captured at Ottenby than at Falsterbo, but robins at Falsterbo carry more fat than robins at Ottenby. Robins with small fat loads at Ottenby probably

Tertiary lymphoid structures (TLS) in the tumor microenvironment are prognostically beneficial in many solid cancer types. Reports on TLS in high-grade serous tubo-ovarian carcinoma (HGSC) are few, and the prognostic impact is unclear. We investigated mature TLS (mTLS), immature TLS (iTLS) and lymphoid aggregates (LA) in primary adnexal tumors (PTs) and synchronous omental/peritoneal metastases (p