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Laminins are a group of extracellular-matrix proteins important in development and disease. They are heterotrimers, and specific domains in the different chains have specialized functions. The G domain of the alpha5 chain has now been produced in transfected mammalian cells as single modules and two tandem arrays, alpha5LG1-3 and alpha5LG4-5 (LG is laminin G domain-like.). Using these fragments we

Popular Abstract in Swedish Två observationer tjänar som utgångspunkt för denna avhandling: (1) globaliseringens allt snabbare och mer eller mindre gränslösa flöde av information har medfört ökad press på företag och organisationer, liksom stater och regioner, att ständigt förnya sig för att kunna behålla sin konkurrenskraft. (2) kunskapsintensiv industri tenderar att samlas i geografisk närhet tiThe accelerated speed and intensity of global interconnections in all segments of society during the last couple of decades have had a profound impact on the workings of contemporary capitalism. Increased pressure is put on national and regional economies to continuously upgrade their competitive advantages, at the same time as new learning opportunities occur at a faster rate than ever. For reaso

Regulation of violaxanthin de-epoxidase (VDE) involves a conformational change at low lumenal pH, followed by binding of the enzyme to the thylakoid membrane. The role of histidine residues in this process was studied by release of unbound enzyme from thylakoids upon sonication, on a pH scale from 4.7 to 7.1. The co-operativity for binding of spinach VDE (four histidines) to the membrane was found

The multi-layer dynamic model SAFE was applied to the forested catchment istebna (Southern Poland), to study recovery from acidification. Environmental pollution in the area has been historically high. The model uses data from an intensive monitoring plot established in 1999 in a spruce stand, which was planted in 1880. Observations showed that the soil was depleted of base cations. The measured b

Background As new product development is becoming more important due to higher and more global competition the new product introduction process needs to be efficient in order to launch new products before they become obsolete. Therefore, a more efficient development process with integrated functions is needed. Concurrent engineering claims to be this and has support in much research. However, conc

In recent years, Deep Learning has proven to be an outstanding tool in the field of computer vision showing promising results in different fields such as the analysis of medical images, obstacle detection for self-driving cars, automatic image caption generation, etc. In the case of Archaeology, the adoption of these methods in the detection of archaeological structures from aerial images has been

Neonicotinoid insecticides are agonists to nicotinic acetylcholine receptors (nAChRs) in the brains of insects. At sub-lethal doses these chemicals cause behavioral abnormalities in several bee species, reducing overall fitness. nAChRs expressed in the optic lobes of insects bind neonicotinoids, thus may be involved in these behavioral changes. Here we attempted without success to visualize the pr

One of the central themes in recent sustainable Development debates is the idea that alternative energy technological solutions can also alleviate poverty in parts of the global South. This idea is earmarked in this study as the alternative energy-poverty discourse. Drawing on Critical Discourse Analysis and Post-development theory; the study questions the extent to which the premise of this disco

För tidigt födda och sjuka barn hamnar på neonatal avdelning där de ofta behandlas med kombinationer av flera olika intravenösa läkemedel. Att kombinera intravenösa läkemedel innebär dock en risk för inkompatibilitet i form av fällningar och subvisuella partiklar, vilket kan riskera i livshotande tillstånd så som till exempel funktionssvikt i flera organ samt allvarliga hjärt- och kärlproblem. SoThere is a lack of data concerning compatibility between intravenously administered drugs, especially for doses administered in neonatal care. Co-administrating drugs or other substances used in hospital care, for instance parenteral nutrition that are incompatible with each other can, in worst case scenarios, lead to fatal outcomes. It is not only important to study drug incompatibility at differ

This thesis explores how welfare crime is discursively constructed as a problem in policy documents from Järfälla, Malmö, and Uppsala, using Carol Bacchi’s What’ s the Problem represented to Be? (WPR) approach. Within a context of turbulence (Ansel et al 2024) the study examines how welfare crime is presented, what remains unproblematized, and the political and discursive effects of these represen

Geophysical methods are increasingly being applied to geotechnical investigations, as they can identify material properties and material boundaries, as well as variations in space and time of relatively large volumes of soil. Another advantage is that many of these methods are non-intrusive. The combination of several methods and the verification of their results by sampling and correlating with g