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The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

The recognition of carbohydrates by proteins is a fundamental aspect of communication within and between living cells. Understanding the molecular basis of carbohydrate-protein interactions is a prerequisite for the rational design of synthetic ligands. Here we report the high- to ultrahigh-resolution crystal structures of the carbohydrate recognition domain of galectin-3 (Gal3C) in the ligand-fre

EUCAARI ion spectrometer measurements at 12 European sites - analysis of new particle formation events

We present comprehensive results on continuous atmospheric cluster and particle measurements in the size range similar to 1-42 nm within the European Integrated project on Aerosol Cloud Climate and Air Quality interactions (EUCAARI) project. We focused on characterizing the spatial and temporal variation of new particle formation events and relevant particle formation parameters across Europe. Dif

Site Preference and Ordering Induced by Au Substitution in the γ-Brass Related Complex Au-Cr-Zn Phases.

Inhibition of Thrombin Formation by Active Site Mutated (S360A) Activated Protein C

Carbon storage in the organic layers of boreal forest soils under various moisture conditions: A model study for Northern Sweden sites

Sst II polymorphic sites in the promoter region of the human cystatin C gene

Wound classification is more important than site of ulceration in the outcome of diabetic foot ulcers

The dorsal vagal complex as a site for cocaine- and amphetamine-regulated transcript peptide to suppress gastric emptying.

Cocaine- and amphetamine-regulated transcript-derived peptides (CARTp) and corticotropin-releasing factor (CRF) alter feeding and gastrointestinal function after central administration, and the gastric inhibitory effects are mediated through CRF. We hypothesized that dorsal hindbrain effects of CARTp on gastric emptying are mediated by the vagus nerve and that the dorsal vagal complex (DVC) is a s

Autoimmune responses against the apo B-100 LDL receptor-binding site protect against arterial accumulation of lipids in LDL receptor deficient mice.

Background: Oxidation of LDL is associated with generation of autoantibodies against a large number of different aldehyde-modified peptide sequences in apo B-100. Autoantibodies recognizing peptide sequences in the LDL receptor-binding region of apo B-100 could potentially affect both cholesterol metabolism and atherosclerosis. The aim of the present study was to determine physiological effects of

Response of six European forest sites to decided and proposed air pollutant emission reductions

Redox potentials of the blue copper sites of bilirubin oxidases

Site-level model intercomparison of high latitude and high altitude soil thermal dynamics in tundra and barren landscapes

Ionization-site effects on the photofragmentation of chloro- and bromoacetic acid molecules

Simulation of CO2 and Attribution Analysis at Six European Peatland Sites Using the ECOSSE Model

Comparison of Methods to Obtain Force-Field Parameters for Metal Sites

Variability in exchange of CO2 across 12 northern peatland and tundra sites

Bark lesions on beech (Fagus sylvatica) and their relation to epiphytes and site variables in Scania, south Sweden.

Structural and energetic characteristics of the heparin-binding site in antithrombotic protein C

N-unsubstituted glucosamine in heparan sulfate of recycling glypican-1 from suramin-treated and nitrite-deprived endothelial cells. mapping of nitric oxide/nitrite-susceptible glucosamine residues to clustered sites near the core protein

We have analyzed the content of N-unsubstituted glucosamine in heparan sulfate from glypican-1 synthesized by endothelial cells during inhibition of (a) intracellular progression by brefeldin A, (b) heparan sulfate degradation by suramin, and/or (c) endogenous nitrite formation. Glypican-1 from brefeldin A-treated cells carried heparan sulfate chains that were extensively degraded by nitrous acid

Identification of autoantibodies in human plasma recognizing an apoB-100 LDL receptor binding site peptide