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CHD7 is one of nine members of the chromodomain helicase DNA-binding domain family of ATP-dependent chromatin remodeling enzymes found in mammalian cells. De novo mutation of CHD7 is a major cause of CHARGE syndrome, a genetic condition characterized by multiple congenital anomalies. To gain insights to the function of CHD7, we used the technique of chromatin immunoprecipitation followed by massiv

Northern forest soils are a major carbon (C) reservoir of global importance. To estimate how the C balance in these soils will change, the roles of tree roots and soil microbes in C balance should first be decoupled. This study determined how the activity of heterotrophs and tree roots together with root-associated microbes in the rhizosphere varies in coniferous forest soils in boreal, hemiboreal

Background: PALB2 monoallelic loss-of-function germ-line variants confer a breast cancer risk comparable to the average BRCA2 pathogenic variant. Recommendations for risk reduction strategies in carriers are similar. Elaborating robust criteria to identify loss-of-function variants in PALB2 - without incurring overprediction - is thus of paramount clinical relevance. Towards this aim, we have perf

Atmospheric new particle formation (NPF) is an important phenomenon in terms of global particle number concentrations. Here we investigated the frequency of NPF, formation rates of 10 nm particles, and growth rates in the size range of 10–25 nm using at least 1 year of aerosol number size-distribution observations at 36 different locations around the world. The majo

Hypoxia is a well-described phenomenon in the offshore waters of the Baltic Sea with both the spatial extent and intensity of hypoxia known to have increased due to anthropogenic eutrophication, however, an unknown amount of hypoxia is present in the coastal zone. Here we report on the widespread unprecedented occurrence of hypoxia across the coastal zone of the Baltic Sea. We have identified 115

En geologisk turistguide över Söderåsen i Skåne har utarbetats i samarbete med Svalövs kommun. Syftet med guiden är att öka kunskapen om Söderåsens unika geologi samt tipsa om geologiskt intressanta besökslokaler inom området. Information om geologi och lokaler har inhämtats via skriftliga publikationer, från Sveriges geologiska undersöknings (SGU:s) kartblad med beskrivningar samt genom dokumenta

The leaching of metals caused by drainage of peatland soils was, in Scania, brought to attention after a flood in Kristianstad 2007. The flood caused large areas of wet meadows to be covered in iron (Fe) and aluminum (Al) contaminated water and one of the affected areas was Fredriksdalsviken, a nature reserve important as a breeding area for birds. The negative effects of these metals on macroinve