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PURPOSEAPR-246 (PRIMA-1MET) is a novel drug that restores transcriptional activity of unfolded wild-type or mutant p53. The main aims of this first-in-human trial were to determine maximum-tolerated dose (MTD), safety, dose-limiting toxicities (DLTs), and pharmacokinetics (PK) of APR-246. PATIENTS AND METHODSAPR-246 was administered as a 2-hour intravenous infusion once per day for 4 consecutive d

Background: We have previously identified a locus on human chromosome 20q13.1, encompassing related genes of postulated WFDC-type protease inhibitors and semen coagulum proteins. Three of the genes with WFDC motif also coded for the Kunitz-type protease inhibitor motif. In this report, we have reinvestigated the locus for homologous genes encoding Kunitz motif only. The identified genes have been

The genetic causes of familial breast cancer are still unclear, where only less than 20% have evident germline mutations. Most studies focus on mutations that cause a direct impact in the protein, disregarding the synonymous variants, where the codon is changed but the amino acid encoded remains the same. Synonymous variants can affect mRNA stability and translation, by differences in codon usage

Utredning av E-infrastruktur Summary ............................................................................................................................... 1 Motivering .............................................................................................................................. 3 Bakgrund ....................................................................................

https://www.staff.lu.se/sites/staff.lu.se/files/2021-05/Utredning%20av%20E-infrastruktur%20final_small.pdf - 2026-05-30

Risken för att ett barn ska utveckla autoantikroppar mot vävnadstransglutaminas (TGA) och celiaki beror till hälften på ärftliga faktorer, framför allt av HLA-typen DQ2 på kromosom 6. HLA-DQ2 styr hur bra immunsystemet reagerar på infektioner. Den andra hälften beror på omgivningsfaktorer där kosten tros ha en stor betydelse. Ju mer gluten barnet äter under de första åren i livet desto högre är ri

https://www.teddy.lu.se/resultat-fran-teddy/alla-forskningsartiklar/celiaki/paverkar-barns-matvanor-mellan-9-manader-och-tva-ars-alder-risken-utveckla-autoantikroppar-mot - 2026-05-29

LU Innovation, VentureLab och LU Holding utgör tillsammans innovationsverksamheten vid Lunds universitet.  Vi vill verka för en innovationsvänlig kultur inom universitetet. Vi anordnar föreläsningar, presentationer och kurser för att inspirera och utbilda inom innovation och entreprenörskap. Vi kommer gärna till din instution eller kurs och berättar mer! Tills dess får du gärna ta del av de tips o

https://www.innovation.lu.se/aktuellt - 2026-05-29

MESS23, 7.5 credits The Geographies of Sustainability course provides interdisciplinary perspectives aimed at studying the dynamics of social and environmental change in particular places. The course covers perspectives from a variety of research fields from land-change science and landscape geography to political economy and cultural geography. It aims to advance students’ understanding of the sp

https://www.lumes.lu.se/programme-overview/programme-outline/2nd-semester/geographies-sustainability - 2026-05-29

Brevmall Postadress Box 118, 221 00 Lund Besöksadress John Ericssons väg 3 Telefon 046-222 00 00 Email: forskarutbildning@kansli.lth.se Webbadress www.lth.se It is hereby announced that Despina Christoforidou has composed, for the Degree of Doctor, an academic thesis (150.0 credits) entitled Bling & Other Breaches in Design Research subject: Industrial Design Information is available at: http://ww

https://www.ses.lu.se/en/sites/ses.lu.se.en/files/2023-06/Announcement%20Despina%20Christoforidou.pdf - 2026-05-30

Science Journals — AAAS García-Calzón et al., Sci. Transl. Med. 12, eaaz1803 (2020) 16 September 2020 S C I E N C E T R A N S L A T I O N A L M E D I C I N E | R E S E A R C H A R T I C L E 1 of 13 M E T A B O L I S M Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes Sonia García-Calzón1,2*, Alexander Perfilyev1, Mats Martinell3, Mont

https://www.ludc.lu.se/sites/ludc.lu.se/files/fulltext.pdf - 2026-05-30

Test "Title" ORNIS SCANDINAVICA 17: 221-229. Copenhagen 1986 Number of pairs, timing of egg-laying and clutch size in a subalpine Sand Martin Riparia riparia colony, 1968-1985 Soren Svensson Svensson, S. 1986. Number of pairs, timing of egg-laying and clutch size in a subal- pine Sand Martin Riparia riparia colony, 1968-1985. - Ornis Scand. 17: 221-229. A Sand Martin colony in the subalpine (subar

https://www.luvre.lu.se/sites/luvre.lu.se/files/luvre-069svenssonbacksvala.pdf - 2026-05-30

Bakgrund Truppgymnastik är en relativt ny och populär sport som ursprungligen kommer från Skandinavien. Sporten är indelad i tre delar; tumbling, trampett och fristående. Det är avancerade rutiner och kroppen utsätts för stora krafter vilket kan leda till ökad skaderisk. Vilken typ av skador som är vanligast, skadeincidensen och i vilka moment som skadorna uppkommer inom truppgymnastik är ett rela

https://www.geology.lu.se/sites/geology.lu.se/files/geon01_litt.pdf - 2026-05-30

SKÅA13 Skådespelarprogrammet termin 3 Lunds universitet Konstnärliga fakulteten SKÅA13, Skådespelarprogrammet termin 3, 30 högskolepoäng Acting Programme Semester 3, 30 credits Grundnivå / First Cycle Fastställande Kursplanen är fastställd av Institutionsstyrelsen vid Teaterhögskolan i Malmö 2016-05- 25 att gälla från och med 2016-08-29, höstterminen 2016. Allmänna uppgifter Obligatorisk kurs inom

https://www.thm.lu.se/sites/thm.lu.se/files/2022-10/skaa13_t3_2022_10.pdf - 2026-05-30

SKÅE07 Dramaturgens yrkespraktik 2 Lunds universitet Konstnärliga fakulteten SKÅE07, Dramaturgens yrkespraktik 2, 30 högskolepoäng The Professional Practice of the Dramaturge 2, 30 credits Grundnivå / First Cycle Fastställande Kursplanen är fastställd av Institutionsstyrelsen vid Teaterhögskolan i Malmö 2023-03- 22 att gälla från och med 2024-01-15, vårterminen 2024. Allmänna uppgifter Kursen är e

https://www.thm.lu.se/sites/thm.lu.se/files/2024-03/SK%C3%85E07,%20Dramaturgens%20yrkespraktik%202.pdf - 2026-05-30

Professor Contact details Email: kristina [dot] stenstrom [at] fysik [dot] lu [dot] se Phone: +46 46 222 76 43Organisation Particle and nuclear physics Visiting address: Sölvegatan 14, Lund Room number: K345 Service point: 14 WebpageKristina Stenströms profile in Lund University research portalOther affiliations Member of Strategic Research Area MERGE: ModElling the Regional and Global Earth syste

https://www.particle-nuclear.lu.se/kristina-stenstrom - 2026-05-29

The tensions between tendencies to support and reject that can be observed in reception measures for newly-arrived students in Sweden are a consequence both of the general climate of hostility towards immigration in Europe, and features particular to Sweden. The paper summarises the historical background to the present situation, from the 1960s onwards, and points to some of the impacts for teache

Palaeoecological methods and environmental analysis, 15 ECTS credits You might wonder what changes the environment has undergone since the last ice age until today? How has the landscape changed and how have flora and fauna responded to variations in climate and in human activity?If you attend this course, you will be able to answer such questions and not least obtain knowledge of up-to-date metho

https://www.geology.lu.se/education/programme-structure/cancelled-courses/geon06-cancelled - 2026-05-29

Members of the PAR-1/MARK kinase family play critical roles in polarity and cell cycle control and are regulated by 14-3-3 scaffolding proteins, as well as the LKB1 tumour suppressor kinase and atypical protein kinase C (PKC). In this study, we initially investigated the mechanism underlying the interaction of mammalian MARK3 with 14-3-3. We demonstrate that 14-3-3 binding to MARK3 is dependent on