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Background: Emerging evidence suggests that artificial intelligence (AI) can increase cancer detection in mammography screening while reducing screen-reading workload, but further understanding of the clinical impact is needed. Methods: In this randomised, controlled, parallel-group, non-inferiority, single-blinded, screening-accuracy study, done within the Swedish national screening programme, wo
Cancer represents a collection of malignancies characterized by an aberrant expansion of cells. This unrestrained growth is the result of the acquisition of several pro-survival features and the evasion of cellular fail-safe mechanisms, collectively known as the hallmarks of cancer. In the clinical setting, disease management has heavily relied on the sole targeting of malignant cells but, except
The quinoline-3-carboxamides (Q compounds) are a family of small molecules with immunomodulatory functions that have shown efficacy in various murine models of inflammatory diseases. One such compound has demonstrated antitumor effects in murine models. Q compounds bind to S100A9, thereby preventing its ligation to TLR4 and RAGE. S100A9 is a small molecule which has shown to have a role in the est
Varje cell har ett membran som skapar en gräns mot omvärlden och skyddarcellen. Men cellen måste alltjämt utbyta viktiga molekyler med omvärlden för attöverleva. Därför finns specialiserade proteiner, som sitter i membranen och utgörportar i denna barriär. Denna avhandling fokuserar på två membranproteiner, enprotonpump och en jonkanal.Varje dag i våra liv använder vi hjärnan, muskler och hjärtat.NADH:quinone oxidoreductase (Complex I) is the first enzyme of the respiratory chain and is involved in energy conservation generating an electro-chemical gradient across a membrane. The enzyme can be divided into a membrane spanning domain and a hydrophilic domain, which protrudes from the membrane. In the hydrophilic domain electrons from NADH oxidation are transported via a wire of iron-sulfur
This thesis is a study of social life, addressing issues concerning how and by what means people meet in urban public space. The main aim of this thesis is to is to investigate how certain artefacts and architectural features support the formation and temporal stabilisation of heterogeneous clusters and collectives, and thus, in order to the development of conceptual tools that can contribute to a
Human activities have a huge impact on the carbon cycle by modifying the landscape. Vegetation cover changes attributed to forest clearance and the expansion of agricultural land increases soil erosion, organic matter and other nutrient delivery from terrestrial to aquatic ecosystems. Long-term records of environmental variation at centennial to millennial time scales are essential for the assessm
Since very few products are truly lifecycle adapted, most products need supportive functions during part(s) of their lifecycle — ranging from extensive systems of primary, secondary and tertiary packages to a simple wrapping or chemical surface protection. When a package is needed, consideration is seldom given to it during the actual development of the product. See Bramklev (2004). An illustrat
Popular Abstract in Swedish Östersjön är ett av världens största brackvattenhav och har stora miljömässiga problem orsakade av övergödning och varmare klimat. Det mer saltrika bottenvattnet som flödar in genom en smal förbindelse med Nordsjön skiljs från ytvattnet av en haloklin, vilket förhindrar ett utbyte av syre mellan de två vattenmassorna. Tillförsel av näring och ett varmare klimat leder tiThe Baltic Sea is one of the largest brackish water bodies in the world and is suffering extensive environmental issues caused by eutrophication and warming climate. A halocline in the water column divides more saline bottom water fed by inflows through the narrow connection with the North Sea from the surface waters and inhibiting exchange of oxygen between the two water masses. With the nutrient
Popular Abstract in Swedish Polymerelektrolytbränslecellen utmärker sig som en framtida effektiv och miljövänlig kraftkälla för bland annat fordon. Den bakomliggande teknologin är dock komplex och grundar sig till stor del på material och komponenter som kräver ytterliggare utveckling. En av de största hindren för bränslecellsteknologins utveckling är kravet på nya, långlivade och billiga polymermThe proton exchange membrane fuel cell (PEMFC) is currently emerging as an efficient and environmentally friendly power source. The technology is very complex and relies ultimately on materials and components which need further development. One of the major hurdles for advancing the PEMFC technology is currently the demand for new durable low-cost polymeric membranes that will allow fuel cell oper
Based upon earlier experimental work by our group, we have started a human immuno-gene therapy study. The goal is to study the effects of immunisation with autologous tumour cells expressing gene sequences for human interferon-gamma For more than two decades we have sought for efficient treatment against malignant gliomas. Our most successful treatment in the animal models is immuno-gene therapy w
In blood, the oxygen-transporting protein hemoglobin (Hb) governs the oxygenation of cells and tissues. Naturally, this protein has claimed a place in the center of the research field of artificial oxygen therapeutics. Such Hb-based products have used cell-free Hb purified from human, bovine, invertebrate, or recombinant sources to create hemoglobin-based oxygen carriers (HBOCs). However, administ
This master thesis was partly performed as a field study in Gaborone, the capital city of Botswana, located in southern Africa. The semi-arid climate in Botswana together with a rapid financial development in the country during the last decades has increased the need for water. The last years the water situation has been strained in Gaborone, and Gaborone dam which used to be one of the city’s dri
Importance: Blood phosphorylated tau (p-tau) and amyloid-β peptides (Aβ) are promising peripheral biomarkers of Alzheimer disease (AD) pathology. However, their potential alterations due to alternative mechanisms, such as hypoxia in patients resuscitated from cardiac arrest, are not known. Objective: To evaluate whether the levels and trajectories of blood p-tau, Aβ42, and Aβ40 following cardiac a
Background: Posterior cortical atrophy is a rare syndrome characterised by early, prominent, and progressive impairment in visuoperceptual and visuospatial processing. The disorder has been associated with underlying neuropathological features of Alzheimer's disease, but large-scale biomarker and neuropathological studies are scarce. We aimed to describe demographic, clinical, biomarker, and neuro
The glymphatic system is a brain-wide solute clearance system that has developed in the brain to clear metabolic waste during sleep. This clearance is mediated by advective fluxes of cerebrospinal fluid (CSF) along perivascular spaces (PVS) and through the brain. The movement of CSF from the PVS and through the brain is dependent on the polarised expression of aquaporin-4 (AQP4) at astrocyte endfe
This report consists of five tasks which were designed to gain an in-depth and broad understanding of the state-of-the-art on research, policy and practice on integration of refugees and host community relations. This was undertaken to form a foundation upon which to build Work Packages focusing on the field work (WP 3 and 4), the development of a refugee and host community toolbox (WP5 and 6) and
Popular Abstract in Swedish Bilsäten har genomgått en kontinuerlig utveckling ända sedan de först beskrevs år 1885. På den tiden kunde man läsa om vadderade läderbänkar, monterade på stora fjädrar, fastsatta i chassit på ”hästlösa vagnar”. När polyuretanskum först började tillverkas på 1950-talet introducerades de snabbt i bilsätena och dessa genomgick stora förbättringar. Skummen utgör idag en stAutomotive seating has been under continous development since it was described for the first time in 1885. At that time one could read about a “padded leather bench seat sitting on springs mounted directly to the frame of a horse-less carriage”. With the development of flexible polyurethane foam in 1950-1960 the seats were considerably improved and the traditional springs were eventually replaced
