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Testing ofIntegrated Circuits is important to ensure the production offault-free chips. However, testing is becoming cumbersome andexpensive due to the increasing complexity of these ICs. Technologydevelopment has made it possible to produce chips where a completesystem, with an enormous transistor count, operating at a highclock frequency, is placed on a single die - SOC (System-on-Chip).The devi
It has been generally accepted that residual cartilage and subchondral bone has to be removed in order to get bony fusion in arthrodeses. In 1998 we reported successful fusion of 11 rheumatoid ankles, all treated with percutaneous fixation only. In at least one of these ankle joints there was cartilage left. More than 25 rheumatoid patients with functional alignment in the ankle joint have subsequ
Popular Abstract in Swedish TNF (Tumor Necrosis Factor eller Tumör-Nekrotisk-Faktor) är en molekyl som utsöndras av kroppens makrofager (latin för storätare) när dessa kommer i kontakt med bakterier. Det TNF som bildas aktiverar andra celler, särskilt vita blodkroppar och de celler som täcker blodkärlsväggens yta (endotelceller). Syftet med detta är att aktivera kroppens immunförsvar och döda baktTNF (Tumor Necrosis Factor) is a pro-inflammatory cytokine which binds to two cell surface receptors, TNF-R55 and TNF-R75. The receptors undergo proteolytic cleavage and release a fragment (soluble TNF-receptors or TNF-Binding Protein), TNF-R55-BP and TNF-R75-BP. Soluble TNF-receptors are able to bind and inactivate TNF. The release of soluble TNF-receptors was measured with ELISA. TNF binding cap
Popular Abstract in Swedish Humana neutrofiler är vita blodkroppar med den kortaste livslängden. Varje dag frisätts det miljoner neutrofiler från benmärgen till blodet. Från blodbanan är neutrofiler de första celler som anländer och samlas i en infekterad vävnad. Neutrofiler är mest kända för deras anti-mikrobiella funktion. Dessa celler är rustade med olika proteiner för att kunna hitta och döda The human neutrophil is the most abundant granulocyte and the major type of cell involved in an acute inflammatory response. Neutrophils are armed with various systems of enzymes, that can find and kill pathogens, but unfortunately, these "weapons" cannot distinguish between the host tissues and the "invaders." Therefore, an extensive neutrophil reaction leads to continuous release of toxic metabo
Popular Abstract in English The global energy consumption is increasing regularly due to the increased population and economic development. In contrast the primary energy sources, fossil fuels, are declining substantially. The combustion of fossil fuels contributes to the global climate change via greenhouse effects. To minimize these negative effects a carbon-neutral energy production is demandedThe electrochemical communication between microorganisms and electrodes has substantial implications both for basic understanding of biological electron transfer as well as in diverse applications, such as, microbial electrochemical system (MES), microbial biosensors and in production of valuable chemicals. In these systems the extracellular electron transfer (EET) from microbial metabolism to ele
The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. We have focused on the cleavage specificities of HIV-1 protease, HCV NS3 protease and caspases on short oligopeptides or in native prote
In order to develop new pharmaceuticals, to optimize pharmacotherapy and secure patient safety, documentation of the properties of pharmaceutical formulations is a most important process. A significant practical problem associated with pre-clinical evaluation of lipophilic substances with pharmacological properties is their low aqueous solubility. The overall aim of this thesis was to develop te
Unemployment and precarity have become key features of 21st century work. Employability is presented as a solution to these issues. Individuals are exhorted to manage their employability, in order to be able to exercise choice in the labour market. While employability is individualsʼ responsibility, governments, employers and educational bodies simply provide opportunities for its development. Hig
Popular Abstract in Swedish Beständiga organiska miljögifter, till exempel PCB (Polyklorerade bifenyler), har vållat stora miljöproblem i flera decennier. Dessa föroreningar är kemiskt och biologiskt sett väldigt stabila, vilket gör att de bryts ner mycket långsamt i miljön och alltså kan transporteras långväga med vindar och strömmar. Därför kan man hitta PCB över hela jorden, även i områden där Persistent organic pollutants (POPs) pose serious threats to our global environment. These compounds have high chemical and biological stability and they are also very lipophilic. These characteristics not only render POPs the ability to spread widely and pollute remote areas, they also make them prone to accumulate in adipose tissues of living organisms. Consequently, it is important to monitor P
Adsorption of cationic polyelectrolytes onto polystyrene latices was studied as function of polymer chemical composition and molecular weight, polymer and surface charge density and ionic strength. The ratio between polymer charges and surface charges was close to one when distances between polymer and surface charges were equal. Overcompensation of the surface charge was obtained at higher polyme
Steady state and time-resolved absorption and fluorescence spectroscopy have been used to investigated the energy transfer in photosynthetic purple bacteria. Picosecond light pulses were used in measurements of Rb. sphaeroides WT and a LH1-deleted mutant, demonstrating that the energy trapping into the reaction center in both species occur on the same time-scale, and that the excitation energy is
Mutations in pancreatic duodenal homeobox 1 (PDX-1) can cause a monogenic form of diabetes (maturity onset diabetes of the young 4) in humans, and silencing Pdx-1 in pancreatic β-cells of mice causes diabetes. However, it is not established whether epigenetic alterations of PDX-1 influence type 2 diabetes (T2D) in humans. Here we analyzed mRNA expression and DNA methylation of PDX-1 in human pancr
Popular Abstract in Swedish Mikroorganismer finns överallt! De klarar av att överleva i extrema miljöer, extrema pH, extrema temperaturer och kan motstå strålning och gift i doser som vi inte skulle överleva. Framförallt klarar mikroorganismer av att överleva i en specifik extrem miljö - människan. Hundratals olika mikroorganismer bor på och i oss, i ett antal som långt överskrider vårt eget cellaMicroorganisms are everywhere! They can tolerate many diverse extreme environments, such as the human body. Even though many of us might associate the word microorganism with infections and disease, most are actually either harmless or even beneficial for us. Those commensals often fight off more dangerous bacteria and might also directly benefit their host. The human skin harbors several differen
A consensus protocol for treatment of distal radius fractures (DRF) has been developed to aid clinicians in treatment decision making. The protocol was evaluated in Paper I using a validated subjective outcome instrument, DASH in 518 consecutive patients. A good final subjective result was achieved with the proposed protocol, regardless of initial severity with a low median DASH score in all group
In practice, the catchment hydrologist is often confronted with the task of predicting discharge without having the needed records for calibration. Here, we report the discharge predictions of 10 modellers - using the model of their choice - for the man-made Chicken Creek catchment (6 ha, northeast Germany, Gerwin et al., 2009b) and we analyse how well they improved their prediction in three steps
