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Background: Activated phosphoinositide 3-kinase δ syndrome (APDS) 2 (p110δ-activating mutations causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI]-R1), a recently described primary immunodeficiency, results from autosomal dominant mutations in PIK3R1, the gene encoding the regulatory subunit (p85α, p55α, and p50α) of class IA phosphoinositide 3-kinases. Objectives: We sought

Type 2 diabetes (T2D) is a complex metabolic disease associated with obesity, insulin resistance and hypoinsulinemia due to pancreatic β-cell dysfunction. Reduced mitochondrial function is thought to be central to β-cell dysfunction. Mitochondrial dysfunction and reduced insulin secretion are also observed in β-cells of humans with the most common human genetic disorder, Down syndrome (DS, Trisomy

A new method to determine the concentration of the free protein S in plasma is described. It is an enzyme-linked ligandsorbent assay (ELSA) which utilises the protein S binding capacity of the natural ligand C4b-binding protein (C4BP) to capture the free protein S from plasma samples. The use of C4BP as ligand in the assay is possible due to the high affinity (Kd = 0.1 nM) of the interaction betwe

Popular Abstract in Swedish Denna avhandling behandlar ämnet känselåterkoppling i handproteser. Att mista sin hand är en traumatisk upplevelse och den som har mist sin hand förlorar både känsel och motorik. En rudimentär greppfunktion kan återskapas genom att använda en handprotes. Nya och avancerade proteser som kontrolleras med hjälp av muskelsignaler finns numera på marknaden och dessa myoelektAmputation of the hand implies the loss of the ability to grasp and the ability to "feel". The grasping function can be primitively restored using an active prosthesis. Multi­articulating electrically powered hands have recently made their way to the market and these hands provide enhanced grasping and gripping capabilities. However, these hands provide no direct and conscious sensory feedback to

Change is sweeping through the world of museums, technologically, financially, and ideologically, impacting on the sociocultural evolution of their roles and status. We seek to contribute to ongoing reflections by offering a conceptual framework that links museums with democratic theory, to citizenship and its practices – a domain that is also in notable transition. We connect concretely with the

Introduction: Giant-cell tumor of bone (GCTB) is a locally aggressive histologically benign neoplasm with a less common malignant counterpart. Longitudinal data sources on GCTB are sparse, limited to single institution case series or surgical outcomes studies. The Swedish Cancer Registry is one of the few national population-based databases recording GCTB, representing a unique source to study GCT

Environmentally safe disposal of urban waste is a global concern that recently gained a new dimension through the lens of Environmental Justice, with a growing literature showing correlation between the placement of waste facilities and disadvantaged groups in society. This thesis seeks to verify whether landfills in the city of São Paulo are located in regions where socially and economically vuln

Purpose: With this study, an attempt was made to present an in-depth analysis of and study the interaction between PR agencies and their client’s CSR strategies in order to illuminate the contributions of public relations to these, and also to review current CSR activities applied in Serbia. Furthermore, the purpose was to foster the role of PR as an agent for change regarding CSR strategies. R

En växande världsbefolkning, politiska regleringar och en strävan att öka andelen energi från förnyelsebara källor har resulterat i att intresset för vindkraftsverk ökat. Winfoor AB utvecklar `Triblade’, en ny teknologi för vindkraftsverksblad som ämnar öka effekten samtidigt som bladen kan göras lättare, billigare och enklare att transportera än dagens vindkrafsverksblad.A globally growing population, an increased energy consumption and growing environmental awareness have made the interest for renewable energy sources, such as wind power, higher. As a result of the increased demand the need for new and improved technologies have increased. The energy production of a wind turbine is highly affected by the rotor blade length, which is limited by the massive dead lo

This report provides an analysis and evaluation of the current spatial, environmental and financial resilience of Rågsved Centre in Stockholm. Furthermore, local future risks on resilience are also discussed and the total analysis is synthesised in a new resilient spatial interpretation of the centre. Methods of analysis include a narrative format that comprise of twelve semi-structured interviews

Pulsed electric field (PEF) treatment is a non-thermal process which has a wide range of beneficial effects in food processing. The application of pulsed electric field treatment relevant for this work is as pre-treatment on basil leaves before the drying process. It has been proven that PEF treatment can significantly reduce the drying time due to the electroporation of the guard cells of stomata

PFOS (Perfluoroktansulfonat)-föroreningar har hittats på många ställen i Sverige och i resten av världen, därför finns det ett stort intresse och behov av att kunna kartlägga föroreningarna med fler metoder än vad som finns till-gängligt i dagsläget. Det här examensarbetet har som syfte att undersöka resistivitets- och IP (induced polarization)-mätningars lämplighet att kartlägga PFOS vid en brand

Den konservativa byggbranschen är i utvecklingsfas då olika metoder effektiviseras. Digitaliseringen har kommit längre i utvecklingen jämfört med människan, ändå nyttjas inte de i den stora omfattningen i det vardagliga arbetet med dess utvecklade potential. I denna studie undersöks hur ekonomiskt och tidsgynnsamt det är med att tillämpa de digitala verktygen vid rapporteringen av avvikelser vid e

När syndafloden kommer När havsnivån stiger och nederbörden ökar riskerar upp till 29 utav Lunds stifts ca 500 kyrkobyggnader att drabbas av översvämningar. Detta betyder att behovet av skydd mot översvämningar troligtvis kommer öka för dessa miljöer i framtiden. Förekomsten av översvämningar förväntas öka till följd av klimatförändringen. Utav de ca 500 kyrkobyggnaderna i Lunds stift kan upp t

Purpose: This study aims to examine changes in the acquired company’s MCS post-M&A and how the employees perceive this change. Further, the purpose is to investigate how employees' perceptions affect the employees’ motivation and identity. Methodology: This study follows a qualitative research approach by analyzing an acquired company in the logistic industry. Data was collected through s

This MSc Thesis’s main objective is to determine the impact of transformer inrush currents in the grid and develop a tool that helps E.ON Energidistribution AB evaluate transformer sizing. The motivation of E.ON is to have a more precise way to estimate the energization consequences of increasing the transformer size in the grid, since currently is being used a rule of thumb that relates the trans

This thesis employed several portable sensors on board an unmanned aerial vehicle (UAV) and manned aircraft in order to test new methods of measuring vertical profiles of aerosol particles and contribute to knowledge of aerosol distributions in the atmosphere. More data in this area is required to improve atmospheric modelling and future climate scenarios. The handheld nanoparticle detector Partec

Klimatförändringar är en av vår tids stora utmaningar. För att kunna möta dessa finns det ett brådskande behov av att minska vart stora beroende av fossila bränslen. En lovande råvara för produktion av förnyelsebara och koldioxidneutrala bränslen är bioolja. Bioolja kan användas som ett substitut för råolja i raffinaderier och produceras från biomassa, vilket innebär att den kan agera som ett förnTo be able to face the challenges brought on by climate change there is an urgent need to reduce the heavy dependence on fossil fuels. Bio-oil is one such renewable and carbon-neutral replacement that has shown promising potential. A key step in making bio-oil commercially feasible is improvements of the upgrading processes of the bio-oil. One such upgrading process is catalytic hydrodeoxygenation

Hybrid solutions that combine multiple renewable energy sources, such as solar power and hydro power, are gaining popularity as a means of meeting the growing energy demands while minimising environmental impacts, but also as an opportunity of connecting solar power plants to the grid in areas where this might not be possible unless large investments are made. This master thesis aims to evaluate t