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Land biosphere processes are of central importance to the climate system. Specifically, ecosystems interact with the atmosphere through a variety of feedback loops that modulate energy, water, and CO2 fluxes between the land surface and the atmosphere across a wide range of temporal and spatial scales. Human land use and land cover modification add a further level of complexity to land-atmosphere

Social media facilitates the sharing of ideas, thoughts and information about older people and later life through online networks and communities in contemporary society. Social media content about older people has become important for understanding media representations of older people, but it has not been sufficiently studied. Recent studies suggest that older people are predominantly represente

Soil microorganisms regulate the decomposition of organic matter. However, microbial activities can also be rate-limited by the resource in lowest supply. Arctic ecosystems are being exposed to pronounced climate warming, with arctic greening, treeline advance and shrubification resulting in increased plant-derived carbon (C) inputs to soils, and faster rates of decomposition releasing mineral nut

Wild insect pollinators are essential to cultivated and natural ecosystems globally. Today, many pollinator species are declining. One reason is a general lack of flowering habitats at landscape scales. However, urban areas, including private gardens, may provide flowers, and constitute beneficial habitats for pollinators. Here, we evaluate the ecological outcomes of a citizen science campaign run

Late Quaternary glaciations, deglaciations, sea-level changes and aeolian activity have resulted in an abundance of clastic sediments that currently cover the three Baltic States, Northern Europe almost entirely. The chronology for these deposits has largely been established from luminescence dating. This review synthesises 201 luminescence ages obtained between 2011 and 2021 on sediments in the B

Vegetation optical depth (VOD) from satellite passive microwave sensors has enabled monitoring of aboveground biomass carbon dynamics by building a relationship with static carbon maps over space and then applying this relationship to VOD time series. However, uncertainty in this relationship arises from changes in water stress, as VOD is mainly determined by vegetation water content, which varies

Soil erosion has created landscape problems in many parts of the world and in particular in cold regions where the sensitive permafrost conditions have changed due to climate warming. Such a case occurred in the Tibetan Plateau (TP), which has been strongly affected by global warming and human activities. Monitoring technologies, like remote sensing and field surveys were used to explore soil eros

Right before northern hemisphere’s summer shifts to autumn small insect-eatingbirds start lengthy journeys to tropical regions. It is well established that temporarylack food and annual changes in weather are the ultimate reasons for this behavior.On a proximal level however, the process is poorly understood. Yet crosscontinental bird migration is a widespread phenomenon that has evolved severalti

4-1BB (CD137) is an activation-induced costimulatory receptor that regulates immune responses of activated CD8 T and natural killer cells, by enhancing proliferation, survival, cytolytic activity, and IFNγ production. The ability to induce potent antitumor activity by stimulating 4-1BB on tumor-specific cytotoxic T cells makes 4-1BB an attractive target for designing novel immuno-oncology therapeu

Methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a new drug target that is expressed in cancer cells but not in normal adult cells, which provides an Achilles heel to selectively kill cancer cells. Despite the availability of crystal structures of MTHFD2 in the inhibitor- and cofactor-bound forms, key information is missing due to technical limitations, including (a) the location

Objective: Immediate cartilage structural alterations in the acute phase after an anterior cruciate ligament (ACL) rupture may be a precursor to posttraumatic osteoarthritis (PTOA) development. Our aim was to describe changes in cartilage matrix in the subacute phase of the acutely ACL-injured knee compared to the contralateral uninjured knee. Design: Participants (n = 118) aged 15–40 years with a

Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 diabetes (T2D). To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D

The interaction of protein S with membranes and subsequent combination with complement C4b-binding protein (C4BP) was studied. Protein S interacted with phospholipid vesicles in a calcium-dependent manner typical of other vitamin K-dependent proteins. Association of C4BP with protein S showed no apparent selectivity for membrane-bound or solution phase protein S. When bound to the membrane, the pr

Introduction: Primary health care centers (PHCCs) in Sweden are struggling to maintain a balance between increasing demands of service and supervision and learning activities for a growing number of students. We sought a deeper understanding of primary care physicians and managers behavioral intention towards supervising, and their perceptions of the structural preconditions and support needed.Met

Summary: This narrative review describes efforts to improve the care and prevention of fragility fractures in New Zealand from 2012 to 2022. This includes development of clinical standards and registries to benchmark provision of care, and public awareness campaigns to promote a life-course approach to bone health. Purpose: This review describes the development and implementation of a systematic a