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Popular Abstract in Swedish Utveckling av blodbildande celler sker i benmärgens mikromiljö, som består av cytokiner och tillväxtfaktorer, stromaceller samt extracellulära matrixmolekyler. Extracellulära matrixproteiner och stromaceller i benmärgen utgör en strukturell miljö för hematopoietiska celler, men adhesiva cell-cell och cell-matrix interaktioner påverkar också direkt hematopoietiska cellerDevelopment of hematopoietic cells in bone marrow takes place in association with the hematopoietic microenvironment. Extracellular matrix (ECM) molecules and stromal cells in bone marrow provide a structural environment for hematopoietic cells, but they also directly influence proliferation, differentiation and migration of cells by signal transduction mediated by ligand binding to cell surface a

The subject of this thesis is the clinical use of the oesophageal electrode in electrocardiology. The three areas covered are oesophageal electro- cardiography, the biophysics of transoesophageal atrial stimulation (TAS) and the clinical utility of TAS. The literature is reviewed with respect to these areas. TAS was performed in 64 patients with documented supraventricular tachycardia (SVT) or a

Remote sensing provides spatially and temporally continuous measures of forest reflectance, and vegetation indices calculated from satellite data can be useful for monitoring climate change impacts on forest tree phenology. Monitoring of evergreen coniferous forest is more difficult than monitoring of deciduous forest, as the new buds only account for a small proportion of the green biomass, and t

The addition of crop residues is a common farming practice to increase the organic carbon content of agricultural soils with particular importance in organically managed crops. Residues can be added either from the crop plant itself or from other plants and the type of litter may differentially affect decomposer populations. Effects of litter addition may cascade up to affect generalist predators

BACKGROUND: Little is known about whether the four main manifestations of arterial vascular disease (coronary heart disease=CHD, ischemic stroke, peripheral artery disease=PAD, and aortic (i.e. atherosclerosis/aneurysm) disease=AD) share familial susceptibility. The aim of this nationwide study was to determine the familial risks of concordant (same disease in proband and exposed relative) and dis

(PRELP)-P-hbd is a peptide corresponding to the N-terminal heparin binding domain of the matrix protein proline/arginine-rich end leucine-rich repeat protein (PRELP). (PRELP)-P-hbd inhibits osteoclastogenesis entering pre-fusion osteoclasts through a chondroitin sulfate- and annexin 2-dependent mechanism and reducing the nuclear factor-B transcription factor activity. In this work, we hypothesized

Protein affinity reagents (PARs), most commonly antibodies, are essential reagents for protein characterization in basic research, biotechnology, and diagnostics as well as the fastest growing class of therapeutics. Large numbers of PARs are available commercially; however, their quality is often uncertain. In addition, currently available PARs cover only a fraction of the human proteome, and thei

Purpose To develop a mathematical model to adjust the timing of computed tomography (CT) scans with the hazard of cancer recurrence in time to facilitate early detection of cancer recurrence. Materials and Methods The clinical data were extracted from the randomized Scandinavian Sarcoma Group (SSG) XVIII/Arbeitsgemeinschaft Internistische Onkologie (AIO) trial database. The SSG XVIII/AIO trial was

Popular Abstract in Swedish Svensk populärvetenskaplig sammanfattning: Miljögift är mat för bakterier i grundvatten Jag har undersökt bakteriers nedbrytning av organiska miljögifter i grundvatten och intresserat mig för hur den påverkas av gifternas vidhäftning till sand och bakteriernas aktivitet och mångfald. Sådan kunskap kan bidra till att förhindra gifters spridning till t.ex. drickvatten. Many factors can influence the rate of microbial degradation of organic contaminants in aquifers. Some of these factors, e.g. sorption, the presence of dissolved organic matter (DOM), biomass, redox conditions, cometabolism, microbial community composition, and activity of degrading microorganisms, are addressed in the thesis, with the ambition to gain insights for bioremediation in aquifers, and

Popular Abstract in Swedish Tumörimmunologisk grundkurs: En tumörcell har en gång i tiden varit en vanlig laglydig cell i någon av kroppens vävnader men på grund av arv eller dålig uppväxtmiljö så har denna cell upphört att följa de tillväxt begränsande regler som normala celler rättar sig efter. Förutom att kontrollen av celldelningen upphört så kan tumörcellen uppvisa ett mer eller mindre asociThis study aims at clarifying the role of NO in the immunosuppression induced by in vivo tumor growth and by tumor immunotherapy, and determining whether the inhibition of NO production can be used as an adjuvant in tumor immunotherapy. We have shown previously that tumor cells, glioma (N32) and colon carcinoma (H1D2), when genetically engineered to express such immune stimulatory cytokines as IFN

Children with lesbian, gay, bisexual, trans* and/or queer (LGBTQ) parents have received heightened attention during the processes of policy making regarding adoption and donor insemination legislation in Sweden during the 1990s and early 2000s. Yet, very little academic knowledge exists about children and young people in LGBTQ families and their experiences in schools. We engage the idea of "cultu

Drug treatment has been and will continue to be a successful method in modern medicine that can change the course of a disease. However, it is surprisingly seldom used in the more technically oriented orthopedic surgery. Bone healing and physiological skeletal remodeling involve a complex set of regulated signaling pathways that control the formation of new bone matrix and the resorption of damage

We studied the nature of the relationship between bone mineral density (BMD) and the risk of death among elderly men. BMD was associated with mortality risk and was independent of adjustments for other co-morbidities. A piecewise linear function described the relationship more accurately than assuming the same gradient of risk over the whole range of BMD (p = 0.020). Low BMD was associated with a

Popular Abstract in Swedish Malignt melanom (även kallad melanom) är den farligaste formen av hudcancer. Dess incidens varierar från land till land och är den högsta i Australien, där 46.7 per 100,000 invånare drabbas årligen. I Sverige är melanom den sjätte vanligaste cancersjukdomen. Melanom har blivit allt vanligare under de senaste två decennierna. Om tumören upptäcks på ett tidigt, dvs. lokal“Cutaneous melanoma is a most unpredictable lesion” wrote Alexander Breslow in 1970. He was one of the first to predict outcome in melanoma patients, based on the thickness of the primary tumor, and today this parameter bears his name and remains the main prognostic factor in melanoma. The aim of this thesis has been to contribute to the understanding of melanoma biology in order to make this canc

Stable isotope analyses of tissues have been used to help delineate natal regions and routes of migratory animals. The foundations of such studies are isotopic gradients or differences representing geographic regions and habitat used by the organism that are retained in selected tissues. We sampled peacock butterflies Inachis io on a regional level in southern Sweden to study natural variation and

Tracking migratory movement of small animals with variable migration patterns is difficult with standard mark-recapture methods or genetic analysis. We used stable hydrogen isotope (delta D) measurements of wings from European red admirals Vanessa atalanta to study several aspects of this species' migration. In the central part of southern Europe we found large differences in delta D values betwee

PURPOSE: A Swedish and Norwegian study was designed to examine health-related quality of life (HQL) in patients with head and neck cancer (head and neck) at diagnosis and during treatment and rehabilitation. The overall aim was to examine the impact on HQL at diagnosis depending on tumor location, stage, sex, and age (part I) and to describe HQL longitudinally and determine for which patients and