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Popular Abstract in Swedish Tumörimmunologisk grundkurs: En tumörcell har en gång i tiden varit en vanlig laglydig cell i någon av kroppens vävnader men på grund av arv eller dålig uppväxtmiljö så har denna cell upphört att följa de tillväxt begränsande regler som normala celler rättar sig efter. Förutom att kontrollen av celldelningen upphört så kan tumörcellen uppvisa ett mer eller mindre asociThis study aims at clarifying the role of NO in the immunosuppression induced by in vivo tumor growth and by tumor immunotherapy, and determining whether the inhibition of NO production can be used as an adjuvant in tumor immunotherapy. We have shown previously that tumor cells, glioma (N32) and colon carcinoma (H1D2), when genetically engineered to express such immune stimulatory cytokines as IFN

Children with lesbian, gay, bisexual, trans* and/or queer (LGBTQ) parents have received heightened attention during the processes of policy making regarding adoption and donor insemination legislation in Sweden during the 1990s and early 2000s. Yet, very little academic knowledge exists about children and young people in LGBTQ families and their experiences in schools. We engage the idea of "cultu

Drug treatment has been and will continue to be a successful method in modern medicine that can change the course of a disease. However, it is surprisingly seldom used in the more technically oriented orthopedic surgery. Bone healing and physiological skeletal remodeling involve a complex set of regulated signaling pathways that control the formation of new bone matrix and the resorption of damage

We studied the nature of the relationship between bone mineral density (BMD) and the risk of death among elderly men. BMD was associated with mortality risk and was independent of adjustments for other co-morbidities. A piecewise linear function described the relationship more accurately than assuming the same gradient of risk over the whole range of BMD (p = 0.020). Low BMD was associated with a

Popular Abstract in Swedish Malignt melanom (även kallad melanom) är den farligaste formen av hudcancer. Dess incidens varierar från land till land och är den högsta i Australien, där 46.7 per 100,000 invånare drabbas årligen. I Sverige är melanom den sjätte vanligaste cancersjukdomen. Melanom har blivit allt vanligare under de senaste två decennierna. Om tumören upptäcks på ett tidigt, dvs. lokal“Cutaneous melanoma is a most unpredictable lesion” wrote Alexander Breslow in 1970. He was one of the first to predict outcome in melanoma patients, based on the thickness of the primary tumor, and today this parameter bears his name and remains the main prognostic factor in melanoma. The aim of this thesis has been to contribute to the understanding of melanoma biology in order to make this canc

Stable isotope analyses of tissues have been used to help delineate natal regions and routes of migratory animals. The foundations of such studies are isotopic gradients or differences representing geographic regions and habitat used by the organism that are retained in selected tissues. We sampled peacock butterflies Inachis io on a regional level in southern Sweden to study natural variation and

Tracking migratory movement of small animals with variable migration patterns is difficult with standard mark-recapture methods or genetic analysis. We used stable hydrogen isotope (delta D) measurements of wings from European red admirals Vanessa atalanta to study several aspects of this species' migration. In the central part of southern Europe we found large differences in delta D values betwee

PURPOSE: A Swedish and Norwegian study was designed to examine health-related quality of life (HQL) in patients with head and neck cancer (head and neck) at diagnosis and during treatment and rehabilitation. The overall aim was to examine the impact on HQL at diagnosis depending on tumor location, stage, sex, and age (part I) and to describe HQL longitudinally and determine for which patients and

Popular Abstract in Swedish Sammanväxningar i buken utvecklas efter flertalet kirurgiska bukingrepp och utgör en betydande orsak till tarmvred, buksmärta och infertilitet. Buksammanväxningar skulle potentiellt kunna minskas i omfattning med användande av förebyggande behandling men här finns klara begränsningar i exempelvis effekt och ett stort utrymme för förbättring. De i denna avhandling ingåenPeritoneal adhesions develop after almost all abdominal surgical interventions and represent an important cause of postoperative intestinal obstruction, abdominal discomfort and infertility. Postoperative adhesions can potentially be reduced by using different antiadhesive agents. In the present study, we hypothesized that a combination of oppositely charged polypeptides could effectively decrease

This second edition of the infrared microwindow atlas contains a collection of spectral mi- crowindows commonly used or recently suggested for ground-based, high resolution, infrared solar absoption spectroscopy. These solar observations are aimed at quantifying the abun- dance of trace species in the terrestrial atmosphere. A microwindow is a narrow spectral interval that allows to observe a spec

Introduction: In contact zones, genetic mixing of two taxa can be restricted by prezygotic (e.g. assortative mating) or postzygotic (lower fitness of hybrid offspring) barriers, or a combination of the two. A hybrid zone between two willow warbler subspecies (Phylloscopus trochilus trochilus, P. t. acredula) with distinctive migratory strategies occurs in central Sweden. These subspecies exhibit d

This dissertation discusses aspects of the syntax of Övdalian, a variety spoken by ca. 2,500 people in the province of Dalecarlia in Sweden. Initially, an overview of the history and current status of the language of Älvdalen is given, and the focus of the dissertation is on certain syntactic phenomena that have been well studied from a comparative and diachronic perspective in other Scandinavian

The two major aims of this study are (1) To test the performance of the Landscape Reconstruction Algorithm (LRA) to quantify past landscape changes using historical maps and related written sources, and (2) to use the LRA and map reconstructions for a better understanding of the origin of landscape diversity and the recent loss of species diversity. Southern Sweden, hemiboreal vegetation zone. The

Streptococcus pneumoniae (the pneumococcus) is a common colonizer of the human nasopharynx. Despite a low rate of invasive disease, the high prevalence of colonization results in millions of infections and over one million deaths per year, mostly in individuals under the age of 5 and the elderly. Colonizing pneumococci form well-organized biofilm communities in the nasopharyngeal environment, but

Conclusion: Alpha B-crystallin was found to be an independent prognostic marker for poor prognosis in oral cavity tumours. For oropharyngeal cancer, alpha B-crystallin had no prognostic value. Objective: The aim of this study was to see if earlier findings of alpha B-crystallin as an independent prognostic marker, and SPARC/osteonectin, PAI-1 and uPA as a prognostic combination for poor outcome in

Isoprene emission from Sphagnum species naturally growing at different positions above the water table were measured in a subarctic peatland and at monoliths from a temperate bog. Our objectives were to investigate (1) whether emission rates were species and/or moisture dependent, and (2) whether short-term temperature history had an influence on emission capacity. We expected greater emission cap

The microarchitecture of trabecular bone adapts to its mechanical loading environment according to Wolff's law and alters with age. Trabecular bone is a metabolically active tissue, thus, its molecular composition and microarchitecture may vary between anatomical locations as a result of the local mechanical loading environment. No comprehensive comparison of composition and microarchitecture of t