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Analysis of the distribution and frequency of trisomy 7 in vivo in synovia from patients with osteoarthritis and pigmented villonodular synovitis

Osteoarthritis (OA) and pigmented villonodular synovitis (PVNS) are disorders associated with trisomy 7. The aim of the present study was to determine the frequency and distribution of the cells with +7 in vivo by analyzing sections of paraffin-embedded synovia from patients affected by OA, PVNS, other forms of synovitis [hemorragic synovitis (HS) and chronic synovitis (CS)], and from individuals

Enhanced DNA damage-induced p53 peptide phosphorylation and cell-cycle arrest in Sjögren's syndrome cells.

BackgroundCells from primary Sjögren's syndrome (SS) patients have been reported to show alterations in DNA repair and p53 expression. The DNA-dependent protein kinase (DNA-PK) autoantigen may be involved in both of these alterations in relation to cellular DNA damage responses. We conducted this study of cell-cycle kinetics and p53 to find additional evidence for an abnormal stress response role

Effect of the CGRP receptor antagonist BIBN4096BS in human cerebral, coronary and omental arteries and in SK-N-MC cells.

Several lines of evidence suggest that a calcitonin-gene related peptide (CGRP) receptor antagonist may serve as a novel abortive migraine treatment. Here we present data on a human cell line and isolated human vessels for such an antagonist, BIBN4096BS. On SK-N-MC membranes, radiolabelled CGRP was displaced by both CGRP-(8-37) and BIBN4096BS, yielding pK(i) values of 8.5 and 11.4, respectively. F

Capturing all disease-causing mutations for clinical and research use: toward an effortless system for the Human Variome Project.

The collection of genetic variants that cause inherited disease (causative mutation) has occurred for decades albeit in an ad hoc way, for research and clinical purposes. More recently, the access to collections of mutations causing specific diseases has become essential for appropriate genetic health care. Because information has accumulated, it has become apparent that there are many gaps in our

Immunosuppressive Myeloid Cells in Breast Cancer and Sepsis

Popular Abstract in Swedish Normalt sett skyddar immunförsvaret oss mot farliga och främmande ämnen. En cancercell uppfattas oftast som något defekt och farligt som måste elimineras. Men då och då lyckas cancerceller överleva och manipulerar då vårt immunförsvar till det sämre för oss. Cancer är ett samlingsnamn på sjukdomar orsakade av en ansamling av genetiska förändringar. Dessa förändringar Immune cells play paradoxical roles in cancer progression. On one hand, the immune system protects us against tumor development by recognizing and eliminating cancerous cells. On the other hand, tumor-associated immune cells can contribute to tumor progression by secreting growth factors as well as immunosuppressive, pro-angiogenic and/or pro-metastatic mediators. In this thesis we identified a f

Transplantation of fetal dopamine neurons in Parkinson's disease : PET [18F]6-L-fluorodopa studies in two patients with putaminal implants

Two patients with Parkinson's disease who underwent implantation of fetal mesencephalic tissue into the putamen were serially studied using positron emission tomography and [18F]6-L-fluorodopa ([18F]dopa). The uptake of [18F]dopa is related to the functional integrity of the presynaptic dopaminergic system. Preoperative studies revealed a marked decrease in putamen [18F]dopa uptake, with lesser in

Characterization of Y3 receptor-mediated synaptic inhibition by chimeric neuropeptide Y-peptide YY peptides in the rat brainstem

1. Neuropeptide Y (NPY) and peptide YY (PYY) act at receptors referred to as Y1 and Y2, while the Y3 receptor is specific to NPY and does not recognize PYY. The effects of NPY, its related peptides and a series of newly constructed chimeric NPY-PYY peptides were examined on excitatory and inhibitory postsynaptic currents (e.p.s.cs and i.p.s.cs, respectively) in rat dorsomedial nucleus tractus soli

A Biopsychosocial Approach to the Onset of Childhood Diabetes

Popular Abstract in Swedish Denna avhandling är en del av en prospektiv, longitudinell studie, som avser att studera sambandet mellan psykosociala faktorer och debuten och förloppet av barndiabetes. Diabetes är en av de vanligaste kroniska sjukdomarna hos barn i Sverige och antalet insjuknade ökar. Tillsammans med Finland har Sverige en av de högsta förekomsterna av barndiabetes i världen. SjukdomThis thesis is a part of a prospective multi-centre study concerning psychosocial aspects of importance for the onset and course of insulin-dependent diabetes mellitus (IDDM). The investigated population was all children with onset of IDDM in the participating clinics during 1988 and 1989. Of 79 diseased children, 67 participated in the study. To each child a healthy control child was chosen, 61 a

Methodology for evaluation of hazards from solid waste and landfill generated leachate

Popular Abstract in Swedish Avfall har alltid uppkommit i alla samhällen i alla tider. Det vanligaste sättet att hand om det har varit att samla avfallet i soptippar (deponier) på mark som ansetts obrukbar, t.ex. i sankmarker utanför bebyggelsen. I takt med ökad konsumtion och produktion har också mängderna avfall ökat. Anledningen till att avfall och avfallshantering kommit alltmer i fokus i miljA methodology based on an analytical protocol for evaluation of hazards from landfill leachate and solid waste is described. A dynamic analytical protocol, the LAQUA protocol, including measurements of inorganic and water-quality parameters, polar and non-polar organic marker compounds, and toxicity, was constructed. An acute toxicity test, using the brackish water crustacean Artemia salina as tes

Allman studieplan for utbildning pa forskarniva i fri konst 170531

Konstnär l iga fakulteten i Malmö Dnr: U 2017/225 Allmän studieplan för utbildning på forskarnivå i fri konst ledande till konstnärlig doktorsexamen 1. Identifikation Utbildningsnamn och inriktning: Utbildning på forskarnivå i fri konst Ämneskod: KOKOFK01 Omfattning i högskolepoäng: 240 Nivå: Forskarnivå Examensbenämning: Konstnärlig doktorsexamen i fri konst Engelsk examensbenämning: Doctor of Ph

https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/allman_studieplan_for_utbildning_pa_forskarniva_i_fri_konst_170531.pdf - 2026-05-19

Laurent peutin

Laurent PEUTIN The Wolf Ate my Sheep! Assessing the Social Impacts of the Return of the Wolf on Sheep Herding and Traditional Pastoralism. A Case Study in the French Alps. Author: Laurent Peutin Lund University Centre for Sustainable Studies (LUCSUS) Lund University International Master's programme in Environmental Sciences and Sustainability (LUMES) P.O. Box 170 SE-221 00 Lund; Sweden Phone: 0046

https://www.lumes.lu.se/sites/lumes.lu.se/files/laurent_peutin.pdf - 2026-05-19

Lunds Universitets Föreskrifter För Utbildings- Och Postdoktorstipendier 2020-10-010-01

Postadress Lunds universitet, sektionen Ekonom, Box 117, 221 00 Lund Besöksadress Paradisgatan 5 c Telefon 046-222 71 68, 046-222 00 00 E-post agneta.sjofors@eken.lu.se Rektor Nya föreskrifter för utbildnings- och postdoktorsstipendier Bakgrund Lunds universitet köper sedan den 1 april 2018 sin lönetjänst från Statens servicecenter (SSC). Inför övergången gjorde en genomgång av alla rutiner som be

https://www.intramed.lu.se/sites/intramed.lu.se/files/2023-01/Lunds%20universitets%20f%C3%B6reskrifter%20f%C3%B6r%20utbildings-%20och%20postdoktorstipendier%202020-10-010-01.pdf - 2026-05-19

Wilson transitionsgranularity oct16 short lund

Wilson_Transitions&Granularity_Oct16_short_Lund.pptx Energy  Transi,ons:   Speeds,  Characteris,cs,  and   the  Benefits  of  Granularity   Charlie  Wilson     October  2016   Lund   Global  energy  challenges  require  rapid  and   profound  system  transforma,on   CLIMATE  CHANGE   limit  warming  to  2oC   HEALTH   cleaner  air,  fewer  par=culates   ENERGY  SECURITY   more  diverse,  less  imp

https://www.iiiee.lu.se/sites/iiiee.lu.se/files/wilson_transitionsgranularity_oct16_short_lund.pdf - 2026-05-19

Orwa ajjoub rapport a4 0203 interaktiv

The Development of the Theological and Political Aspects of Jihadi-Salafism The Development of the Theological and Political Aspects of Jihadi-Salafism ORWA AJJOUB CENTER FOR MIDDLE EASTERN STUDIES | SASNET | LUND UNIVERSITY Contents Acknowledgments ............................................................................................................. 3 Glossary of Key Islamic Terms ........

https://www.cmes.lu.se/sites/cmes.lu.se/files/2021-02/orwa_ajjoub_rapport_a4_0203_interaktiv.pdf - 2026-05-19

Riktlinjer-for-inkop-vid-LU

Riktlinjer för inköp vid Lunds universitet FÖRSÄTTSSIDA STYRDOKUMENT Riktlinjer för inköp vid Lunds universitet Typ av styrdokument: Riktlinjer Definition av typen av styrdokument: Riktlinjer fastställer hur någon ska eller bör handla inom det område riktlinjerna omfattar. En ska- regel ska följas medan en bör regel mer har karaktären av en stark rekommendation som innebär att man undantagsvis kan

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2024-10/riktlinjer-for-inkop-vid-LU.pdf - 2026-05-19

Education As A Countermeasure Against Disinformation Eng

WP 2024_3 Education as a countermeasure against disinformation THOMAS NYGREN | ULLRICH K H ECKER LUND UNIVERSITY PSYCHOLOGICAL DEFENCE RESEARCH INSTITUTE | WORKING PAPER 2024:3 LUND UNIVERSITY PSYCHOLOGICAL DEFENCE RESEARCH INSTITUTE, WORKING PAPER 2024:3 1 Education as a countermeasure against disinformation Professor Thomas Nygren, Department of Education, Uppsala University Professor Ullrich K

https://www.psychologicaldefence.lu.se/sites/psychologicaldefence.lu.se/files/2024-11/Education%20as%20a%20countermeasure%20against%20disinformation_Eng.pdf - 2026-05-19

Allman-studieplan-biomedicin-2012-01-01

Brevmall Postadress Box 117, 221 00 LUND Telefon växel 046-222 00 00 Telefax 046-222 41 70 E-post info@med.lu.se Internet http://www.med.lu.se Medic inska faku l tetsstyre l sen Allmän studieplan för utbildning på forskarnivå i biomedicin http://www.med.lu.se/utbildning/forskarutbildning (Fastställd av Medicinska fakultetsstyrelsen 2007-05-24) Studieplanen träder ikraft den 1 juli 2007. Reviderad

https://www.intramed.lu.se/sites/intramed.lu.se/files/2022-12/allman-studieplan-biomedicin-2012-01-01.pdf - 2026-05-19

Yrkesutbildningens irrvagar

Yrke – kvalif kation – rörlighet Yrkesutbildningens irrvägar Av Nils Karlson och Filippa Ronquist Näringslivets forskningsinstitut Yrkesutbildingens irrvägar N äring slivets forskning sinstitut I rapporten Yrkesutbildningens irrvägar görs en systemanalys av svensk yrkesutbild- ning, med fokus på följande frågeställningar: – Hur är yrkesutbildningssystemet utformat och finansierat? – Möjliggör och

https://www.soch.lu.se/sites/soch.lu.se/files/yrkesutbildningens_irrvagar.pdf - 2026-05-19

Publication PNAS

TARGET-seq: Linking single-cell transcriptomics of human dopaminergic neurons with their target specificity PNAS  2024  Vol. 121  No. 47 e2410331121 https://doi.org/10.1073/pnas.2410331121 1 of 12 RESEARCH ARTICLE |  Significance Understanding the molecular basis of dopaminergic (DA) neuron diversity is crucial for both experimental work and clinical applications. Here, we present a comprehensive

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/2024-11/publication_PNAS.pdf - 2026-05-19

2411Working Paper 2024-3Eng

WP 2024_3 Education as a countermeasure against disinformation THOMAS NYGREN | ULLRICH K H ECKER LUND UNIVERSITY PSYCHOLOGICAL DEFENCE RESEARCH INSTITUTE | WORKING PAPER 2024:3 LUND UNIVERSITY PSYCHOLOGICAL DEFENCE RESEARCH INSTITUTE, WORKING PAPER 2024:3 1 Education as a countermeasure against disinformation Professor Thomas Nygren, Department of Education, Uppsala University Professor Ullrich K

https://www.psychologicaldefence.lu.se/sites/psychologicaldefence.lu.se/files/2024-11/2411Working%20Paper%202024-3Eng.pdf - 2026-05-19